Reviewed, UniProtKB/Swiss-Prot Q39EZ0 (ACCA_BURS3)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
      Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha
      Short name=ACCase subunit alpha
    EC=6.4.1.2

Gene names

Name:	accA
Ordered Locus Names:	Bcep18194_A5382

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823
Catalytic activity	ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823
Subunit structure	Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (accB), biotin carboxylase (accC) and two subunits each of ACCase subunit alpha (accA) and ACCase subunit beta (accD) By similarity. HAMAP MF_00823
Subcellular location	Cytoplasm By similarity HAMAP MF_00823.
Sequence similarities	Belongs to the accA family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	acetyl-CoA carboxylase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823		PRO_1000062594

Sequences

	Sequence		Length	Mass (Da)
	Q39EZ0-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 655EC8C7770AF42F	FASTA	323	35,583
	10 20 30 40 50 60 MKTTFLDFEQ PIAELEGKIE ELRFVQDDSA VDISEEIERL SKKSQQLTKD LYANLSPWQV 70 80 90 100 110 120 SQIARHPQRP YTLDYVAELF TDFHELHGDR AFADDVSIVG GLARFGGHPC MVIGHQKGRD 130 140 150 160 170 180 TKERAARNFG MPRPEGYRKA ERLMRLAEKF GLPIFTFVDT PGAYPGIGAE ERGQSEAIGR 190 200 210 220 230 240 NLYVMAELKT PIITTVIGEG GSGGALAIAV ADTVMMLQFS TYSVISPEGC ASILWKSAAK 250 260 270 280 290 300 APEAAEALGL TAHRLKALGL IDKIINEPLG GAHRDPKGMA ALLRRALADS LRQFQGMSID 310 320 ALRERRFERL MAYGKFKETT PGA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000151 Genomic DNA. Translation: ABB08976.1.
RefSeq	YP_369620.1.
3D structure databases
SMR	Q39EZ0. Positions 5-314.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39EZ0.
Genome annotation databases
GeneID	3750601.
GenomeReviews	Gene locus Bcep18194_A5382 in contig CP000151_GR.
KEGG	bur:Bcep18194_A5382.
NMPDR	fig|269483.3.peg.6759.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0825.
HOGENOM	HBG286557.
OMA	HSVYTVA.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A5382-MONOMER.
Family and domain databases
HAMAP	MF_00823. AcetylCoA_CT_alpha. [Tree]
InterPro	IPR001095. Acetyl_CoA_COase_a_su. IPR020582. Acetyl_CoA_COase_a_su_cons-reg. IPR011763. COA_CT_C. [Graphical view]
PANTHER	PTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
Pfam	PF03255. ACCA. 1 hit. [Graphical view]
PRINTS	PR01069. ACCCTRFRASEA.
TIGRFAMs	TIGR00513. accA. 1 hit.
PROSITE	PS50989. COA_CT_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACCA_BURS3

Accession

Primary (citable) accession number: Q39EZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 22, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)