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Protein

Sulfate adenylyltransferase subunit 2

Gene

cysD

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + sulfate = diphosphate + adenylyl sulfate.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 2 (cysD), Sulfate adenylyltransferase subunit 1 (Bcep18194_A5802), Sulfate adenylyltransferase subunit 2 (cysD), Sulfate adenylyltransferase subunit 1 (VL00_03710)
  2. Adenylyl-sulfate kinase (cysC), Adenylyl-sulfate kinase (cysC), Adenylyl-sulfate kinase (cysC), Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenylylsulfate reductase (Thioredoxin) (Bcep18194_A5804), Phosphoadenosine phosphosulfate reductase (VL00_03720)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP269483:GHLS-2372-MONOMER.
UniPathwayiUPA00140; UER00204.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate adenylyltransferase subunit 2UniRule annotation (EC:2.7.7.4UniRule annotation)
Alternative name(s):
ATP-sulfurylase small subunitUniRule annotation
Sulfate adenylate transferaseUniRule annotation
Short name:
SATUniRule annotation
Gene namesi
Name:cysDUniRule annotation
Ordered Locus Names:Bcep18194_A5495
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Sulfate adenylyltransferase subunit 2PRO_0000340189Add
BLAST

Interactioni

Subunit structurei

Heterodimer composed of CysD, the smaller subunit, and CysN.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ39EM7.
SMRiQ39EM7. Positions 2-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263604.
KOiK00957.
OrthoDBiEOG6W45TZ.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00064. Sulf_adenylyltr_sub2.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011784. SO4_adenylTrfase_ssu.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMsiTIGR02039. CysD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39EM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTHLERLEA ESIHIMREVV AESENPVMLY SIGKDSSVML HLAMKAFYPA
60 70 80 90 100
KPPFPLLHVD TTWKFREMIA FRDETAARLG LDLRVHINPD GVANGIDPFT
110 120 130 140 150
HGSAVHTDVW KTQGLKQALD HYGFDAAFGG ARRDEEKSRA KERIVSLRSE
160 170 180 190 200
QHRWDPKRQR PELWSLYNAR KRKGESLRVF PISNWTELDI WQYIQLHDIP
210 220 230 240 250
IVPLYFAKER PVVERDGALI MVDDERLPLR EGEVPQMRKV RFRTLGCYPL
260 270 280 290
TGAIDSDATS LDDILQEMRE TRTSERQGRL IDSDSAGSME KKKQEGYF
Length:298
Mass (Da):34,444
Last modified:November 22, 2005 - v1
Checksum:i915E126D0A8F021F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB09089.1.
RefSeqiWP_011352623.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB09089; ABB09089; Bcep18194_A5495.
KEGGibur:Bcep18194_A5495.
PATRICi19288432. VBIBurSp120713_3606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB09089.1.
RefSeqiWP_011352623.1. NC_007510.1.

3D structure databases

ProteinModelPortaliQ39EM7.
SMRiQ39EM7. Positions 2-207.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB09089; ABB09089; Bcep18194_A5495.
KEGGibur:Bcep18194_A5495.
PATRICi19288432. VBIBurSp120713_3606.

Phylogenomic databases

HOGENOMiHOG000263604.
KOiK00957.
OrthoDBiEOG6W45TZ.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00204.
BioCyciBSP269483:GHLS-2372-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00064. Sulf_adenylyltr_sub2.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011784. SO4_adenylTrfase_ssu.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMsiTIGR02039. CysD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383.

Entry informationi

Entry nameiCYSD_BURL3
AccessioniPrimary (citable) accession number: Q39EM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 22, 2005
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.