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Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N(3)-methylpseudouridine(1915) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBSP269483:GHLS-2510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
23S rRNA m3Psi1915 methyltransferaseUniRule annotation
rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
Gene namesi
Name:rlmHUniRule annotation
Ordered Locus Names:Bcep18194_A5626
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002605401 – 156Ribosomal RNA large subunit methyltransferase HAdd BLAST156

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ39E96.
SMRiQ39E96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA methyltransferase RlmH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218434.
KOiK00783.
OMAiQLERWKL.
OrthoDBiPOG091H028B.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00658. 23SrRNA_methyltr_H. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR016051. RlmH.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFiPIRSF004505. MT_bac. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00246. tRNA_RlmH_YbeA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39E96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFILAVGH KMPGWIASGF DEYTKRMPPE LRIELREIKP ELRSGGRSAE
60 70 80 90 100
SVMAAERQKI EAALPKGARL VALDERGRDW TTMQLAQALP GWQQDGRDVA
110 120 130 140 150
FVIGGADGLD PELKARADTL LRISSMTLPH GMVRVLLAEQ LYRAWSITQN

HPYHRA
Length:156
Mass (Da):17,500
Last modified:November 22, 2005 - v1
Checksum:i1303A3658DDA2AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB09220.1.
RefSeqiWP_011352746.1. NZ_CP013404.1.

Genome annotation databases

EnsemblBacteriaiABB09220; ABB09220; Bcep18194_A5626.
KEGGibur:Bcep18194_A5626.
PATRICi19288727. VBIBurSp120713_3746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB09220.1.
RefSeqiWP_011352746.1. NZ_CP013404.1.

3D structure databases

ProteinModelPortaliQ39E96.
SMRiQ39E96.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB09220; ABB09220; Bcep18194_A5626.
KEGGibur:Bcep18194_A5626.
PATRICi19288727. VBIBurSp120713_3746.

Phylogenomic databases

HOGENOMiHOG000218434.
KOiK00783.
OMAiQLERWKL.
OrthoDBiPOG091H028B.

Enzyme and pathway databases

BioCyciBSP269483:GHLS-2510-MONOMER.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00658. 23SrRNA_methyltr_H. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR016051. RlmH.
IPR003742. SPOUT_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF02590. SPOUT_MTase. 1 hit.
[Graphical view]
PIRSFiPIRSF004505. MT_bac. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00246. tRNA_RlmH_YbeA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMH_BURL3
AccessioniPrimary (citable) accession number: Q39E96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.