Q39DM5DUT_BURL3Deoxyuridine 5'-triphosphate nucleotidohydrolasedUTPase3.6.1.23dUTP pyrophosphatasedutBcep18194_A5847Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)BacteriaPseudomonadotaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complexComplete sequence of chromosome 1 of Burkholderia sp. 383.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.dUTP + H2O = diphosphate + dUMP + H(+)Mg(2+)Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.Belongs to the dUTPase family.HydrolaseMagnesiumMetal-bindingNucleotide metabolismsubstratesubstratesubstratesubstrateMKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVPVVQAQFNIVDDFAESDRGDGGFGSTGRH
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