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Reviewed, UniProtKB/Swiss-Prot Q39DI6 (MURB_BURS3)

Last modified November 3, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase
    EC=1.1.1.158
Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase
Gene names
Name: murB
Ordered Locus Names: Bcep18194_A5886
OrganismBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]
Taxonomic identifier269483 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

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Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the murB family.

Contains 1 FAD-binding PCMH-type domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_0000224673

Regions

Domain24 – 197174FAD-binding PCMH-type

Sites

Active site1731 By similarity
Active site2491Proton donor By similarity
Active site3451 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q39DI6-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 8AA0CFE534348C5D

FASTA34937,566
        10         20         30         40         50         60 
MPMPLDDSTL SLLPDHPLAA HNTFGIAATA RFAARITHAS QFEALHRDPR VAHLPQLVLG 

        70         80         90        100        110        120 
GGSNVVFTRD FDGVVLLDEI AGRRVVREDD DAWYVEAGGG ENWHAFVAWT LEHGMAGLEN 

       130        140        150        160        170        180 
LALIPGTVGA APIQNIGAYG LEMKAYFDSL VAVELATGCS ERFDAARCAF GYRDSFFKRE 

       190        200        210        220        230        240 
GRGRFAIVSV TFRLPKQWVP RLGYADVTRE LDARGIAPDA ATARDVFDAV VAIRRAKLPD 

       250        260        270        280        290        300 
PLVLGNAGSF FKNPVIDAAQ FDALRARAPE VVSYPQPDGQ VKLAAGWLID RCGWKGRALG 

       310        320        330        340 
AAAVHDRQAL VLVNRGGATG ADVLALARAI QADVQTQFGV ELEAEPVCL

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References

[1]"Complete sequence of chromosome 1 of Burkholderia sp. 383."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000151 Genomic DNA. Translation: ABB09480.1.
RefSeqYP_370124.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ39DI6.

Genome annotation databases

GeneID3751117.
GenomeReviewsGene locus Bcep18194_A5886 in contig CP000151_GR.
KEGGbur:Bcep18194_A5886.
NMPDRfig|269483.3.peg.7364.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ39DI6.
OMAIGNAGSF.

Enzyme and pathway databases

BioCycBSP36773:BCEP18194_A5886-MON.

Family and domain databases

HAMAPMF_00037.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMURB_BURS3
AccessionPrimary (citable) accession number: Q39DI6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents