Reviewed, UniProtKB/Swiss-Prot Q39CE5 (BIOD_BURS3)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase
    DTB synthetase
      Short name=DTBS

Gene names

Name:	bioD
Ordered Locus Names:	Bcep18194_A6277

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Dethiobiotin synthetase HAMAP MF_00336		PRO_0000302493
Regions
	Nucleotide binding	11 – 19	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39CE5-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 48AB76EB86AAC2EB	FASTA	239	25,011
	10 20 30 40 50 60 MTAPLSLFVT GTDTEIGKTF VSAALLHGFA RHGLRAAALK PVAAGAYERD GVWRNEDADQ 70 80 90 100 110 120 LDAAANVVLP PELRTPFLLK APAAPHIVAA QEGVTLDIDT IVACHREALT RADVVVVEGA 130 140 150 160 170 180 GGFRVPMNDT QDLADLAVAL GVPVVLVVGV RLGCINHALL TADAIAARGL KLAGWVANHV 190 200 210 220 230 DPAMSFPDEN IATMRDWLAR EHGAPLLGRI PHMSPAAPES AAAMLDIAAL VETLRTAQP

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000151 Genomic DNA. Translation: ABB09871.1.
RefSeq	YP_370515.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q39CE5.
Genome annotation databases
GeneID	3751510.
GenomeReviews	Gene locus Bcep18194_A6277 in contig CP000151_GR.
KEGG	bur:Bcep18194_A6277.
NMPDR	fig|269483.3.peg.7096.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39CE5.
OMA	WIANCAT.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A6277-MON.
Family and domain databases
HAMAP	MF_00336. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD_BURS3

Accession

Primary (citable) accession number: Q39CE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)