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Q39BD8 (Q39BD8_BURS3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH1 HAMAP MF_00191
Ordered Locus Names:Bcep18194_B0106
OrganismBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP] EMBL ABB10223.1
Taxonomic identifier269483 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q39BD8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: DFADFF2D91DA366E

FASTA31333,781
        10         20         30         40         50         60 
MRVILAQPRG FCAGVVRAIE IVDRALQQHG APVYVRHEIV HNRHVVENLR NKGARFVEEL 

        70         80         90        100        110        120 
DEVPHGAVAI FSAHGVAQTV ERDAETRGLD VLDATCPLVT KVHVQGRQYV AAGRRLILIG 

       130        140        150        160        170        180 
HAGHPEVEGT IGQIPAEVIL VQSEAEVDTL TVPVDTPVAY ITQTTLSVDD TRGIIEALQR 

       190        200        210        220        230        240 
RFTDLVGPDT RDICYATQNR QAAVRELSEQ VDVLLVVGAT NSSNSNRLRE IGTESGVPSY 

       250        260        270        280        290        300 
LVADGSEVKA EWFANAKTVG LTAGASAPEE MVEDVIGALR ALGPVDVTTM AGREEKVEFK 

       310 
LPAKLTQAVA REV

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia sp. 383."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 383.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000152 Genomic DNA. Translation: ABB10223.1.
RefSeqYP_370867.1. NC_007511.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ39BD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3752001.
GenomeReviewsGene locus Bcep18194_B0106 in contig CP000152_GR.
KEGGbur:Bcep18194_B0106.
NMPDRfig|269483.3.peg.1045.
PATRIC19290846. VBIBurSp120713_4793.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAHNQGKRY.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ39BD8_BURS3
AccessionPrimary (citable) accession number: Q39BD8
Entry history
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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