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Q39AS8

- GCH41_BURS3

UniProt

Q39AS8 - GCH41_BURS3

Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei166 – 1661May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBSP269483:GHLS-3730-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2-1UniRule annotation
    Ordered Locus Names:Bcep18194_B0317
    OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
    Taxonomic identifieri482957 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002705: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316GTP cyclohydrolase FolE2 1PRO_0000289482Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269483.Bcep18194_B0317.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39AS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39AS8-1 [UniParc]FASTAAdd to Basket

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    MEKALHRISS MNAPLPDISL TDAAPGGRPL EWVGMQGIDL PVAVAEPGCR    50
    RDVHARADVQ VDLPAPHVKG IHMSRLYRLL DGLGDGTALS PAGLQHVLHA 100
    MVDSHRDCDT RSARLRLRFD LLARRAALVT DGLAGWKAYP VRIDATLSGA 150
    RFELRAQVTV VYSSTCPCSA ALSRHWVEQA FLAAFGHDDR VEPAAVAAWL 200
    KRHATAATPH SQRSEAVVSV ALPADGATLG LIDLIDRIEH ALGTPVQTAV 250
    KRADEQAFAV LNGGNLMFVE DAARRVQAAL DGHHANPRVH VRHLESLHPH 300
    DAVAWAAPVR EGADAC 316
    Length:316
    Mass (Da):33,976
    Last modified:November 22, 2005 - v1
    Checksum:i4610995773F63D32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000152 Genomic DNA. Translation: ABB10433.1.
    RefSeqiWP_011353931.1. NC_007511.1.
    YP_371077.1. NC_007511.1.

    Genome annotation databases

    EnsemblBacteriaiABB10433; ABB10433; Bcep18194_B0317.
    GeneIDi3752076.
    KEGGibur:Bcep18194_B0317.
    PATRICi19291300. VBIBurSp120713_5020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000152 Genomic DNA. Translation: ABB10433.1 .
    RefSeqi WP_011353931.1. NC_007511.1.
    YP_371077.1. NC_007511.1.

    3D structure databases

    ProteinModelPortali Q39AS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269483.Bcep18194_B0317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB10433 ; ABB10433 ; Bcep18194_B0317 .
    GeneIDi 3752076.
    KEGGi bur:Bcep18194_B0317.
    PATRICi 19291300. VBIBurSp120713_5020.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BSP269483:GHLS-3730-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia sp. 383."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 383.

    Entry informationi

    Entry nameiGCH41_BURS3
    AccessioniPrimary (citable) accession number: Q39AS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3