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Q39AS8 (GCH41_BURS3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2 1

EC=3.5.4.16
Gene names
Name:folE2-1
Ordered Locus Names:Bcep18194_B0317
OrganismBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]
Taxonomic identifier482957 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316GTP cyclohydrolase FolE2 1 HAMAP-Rule MF_01527
PRO_0000289482

Sites

Site1661May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q39AS8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 4610995773F63D32

FASTA31633,976
        10         20         30         40         50         60 
MEKALHRISS MNAPLPDISL TDAAPGGRPL EWVGMQGIDL PVAVAEPGCR RDVHARADVQ 

        70         80         90        100        110        120 
VDLPAPHVKG IHMSRLYRLL DGLGDGTALS PAGLQHVLHA MVDSHRDCDT RSARLRLRFD 

       130        140        150        160        170        180 
LLARRAALVT DGLAGWKAYP VRIDATLSGA RFELRAQVTV VYSSTCPCSA ALSRHWVEQA 

       190        200        210        220        230        240 
FLAAFGHDDR VEPAAVAAWL KRHATAATPH SQRSEAVVSV ALPADGATLG LIDLIDRIEH 

       250        260        270        280        290        300 
ALGTPVQTAV KRADEQAFAV LNGGNLMFVE DAARRVQAAL DGHHANPRVH VRHLESLHPH 

       310 
DAVAWAAPVR EGADAC 

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia sp. 383."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 383.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000152 Genomic DNA. Translation: ABB10433.1.
RefSeqYP_371077.1. NC_007511.1.

3D structure databases

ProteinModelPortalQ39AS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269483.Bcep18194_B0317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB10433; ABB10433; Bcep18194_B0317.
GeneID3752076.
KEGGbur:Bcep18194_B0317.
PATRIC19291300. VBIBurSp120713_5020.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAAGRTTIQ.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycBSP269483:GHLS-3730-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH41_BURS3
AccessionPrimary (citable) accession number: Q39AS8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways