Q39AS8 (GCH41_BURS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2 1
EC=3.5.4.16

Gene names

Name:	folE2-1
Ordered Locus Names:	Bcep18194_B0317

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	GTP cyclohydrolase folE2 1 HAMAP-Rule MF_01527		PRO_0000289482
Sites
	Site	166	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39AS8 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 4610995773F63D32	FASTA	316	33,976
	10 20 30 40 50 60 MEKALHRISS MNAPLPDISL TDAAPGGRPL EWVGMQGIDL PVAVAEPGCR RDVHARADVQ 70 80 90 100 110 120 VDLPAPHVKG IHMSRLYRLL DGLGDGTALS PAGLQHVLHA MVDSHRDCDT RSARLRLRFD 130 140 150 160 170 180 LLARRAALVT DGLAGWKAYP VRIDATLSGA RFELRAQVTV VYSSTCPCSA ALSRHWVEQA 190 200 210 220 230 240 FLAAFGHDDR VEPAAVAAWL KRHATAATPH SQRSEAVVSV ALPADGATLG LIDLIDRIEH 250 260 270 280 290 300 ALGTPVQTAV KRADEQAFAV LNGGNLMFVE DAARRVQAAL DGHHANPRVH VRHLESLHPH 310 DAVAWAAPVR EGADAC

References

[1]

"Complete sequence of chromosome 2 of Burkholderia sp. 383." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000152 Genomic DNA. Translation: ABB10433.1.
RefSeq	YP_371077.1. NC_007511.1.
3D structure databases
ProteinModelPortal	Q39AS8.
ModBase	Search...
Protein-protein interaction databases
STRING	269483.Bcep18194_B0317.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB10433; ABB10433; Bcep18194_B0317.
GeneID	3752076.
KEGG	bur:Bcep18194_B0317.
PATRIC	19291300. VBIBurSp120713_5020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000247517.
KO	K09007.
OMA	LNGQNLM.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	BSP269483:GHLS-324-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 2 hits.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH41_BURS3

Accession

Primary (citable) accession number: Q39AS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program