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Q39AS8

- GCH41_BURS3

UniProt

Q39AS8 - GCH41_BURS3

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Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBSP269483:GHLS-3730-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-1UniRule annotation
Ordered Locus Names:Bcep18194_B0317
OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002705: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316GTP cyclohydrolase FolE2 1PRO_0000289482Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269483.Bcep18194_B0317.

Structurei

3D structure databases

ProteinModelPortaliQ39AS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39AS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKALHRISS MNAPLPDISL TDAAPGGRPL EWVGMQGIDL PVAVAEPGCR
60 70 80 90 100
RDVHARADVQ VDLPAPHVKG IHMSRLYRLL DGLGDGTALS PAGLQHVLHA
110 120 130 140 150
MVDSHRDCDT RSARLRLRFD LLARRAALVT DGLAGWKAYP VRIDATLSGA
160 170 180 190 200
RFELRAQVTV VYSSTCPCSA ALSRHWVEQA FLAAFGHDDR VEPAAVAAWL
210 220 230 240 250
KRHATAATPH SQRSEAVVSV ALPADGATLG LIDLIDRIEH ALGTPVQTAV
260 270 280 290 300
KRADEQAFAV LNGGNLMFVE DAARRVQAAL DGHHANPRVH VRHLESLHPH
310
DAVAWAAPVR EGADAC
Length:316
Mass (Da):33,976
Last modified:November 22, 2005 - v1
Checksum:i4610995773F63D32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000152 Genomic DNA. Translation: ABB10433.1.
RefSeqiWP_011353931.1. NC_007511.1.
YP_371077.1. NC_007511.1.

Genome annotation databases

EnsemblBacteriaiABB10433; ABB10433; Bcep18194_B0317.
GeneIDi3752076.
KEGGibur:Bcep18194_B0317.
PATRICi19291300. VBIBurSp120713_5020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000152 Genomic DNA. Translation: ABB10433.1 .
RefSeqi WP_011353931.1. NC_007511.1.
YP_371077.1. NC_007511.1.

3D structure databases

ProteinModelPortali Q39AS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269483.Bcep18194_B0317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB10433 ; ABB10433 ; Bcep18194_B0317 .
GeneIDi 3752076.
KEGGi bur:Bcep18194_B0317.
PATRICi 19291300. VBIBurSp120713_5020.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BSP269483:GHLS-3730-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 383.

Entry informationi

Entry nameiGCH41_BURS3
AccessioniPrimary (citable) accession number: Q39AS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3