Reviewed, UniProtKB/Swiss-Prot Q39A44 (BETA_BURS3)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	Bcep18194_B0553

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Choline dehydrogenase		PRO_0000258921
Regions
	Nucleotide binding	7 – 36	30	FAD Probable
Sites
	Active site	474	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39A44-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 19B87861F31C800A	FASTA	566	62,947
	10 20 30 40 50 60 MTTREYDYII CGAGSAGNVL ATRLTEDPDV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 70 80 90 100 110 120 RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW STHKGLENWT 130 140 150 160 170 180 YLDCLPYFKK AETRDVGPND YHGGNGPVSV TTSKPGVNPL FEAMVDAGVQ AGYPRTDDLN 190 200 210 220 230 240 GYQQEGFGPM DRTVTPKGRR ASTARGYLDQ AKVRPNLEIV THALADRILF DGKRASGVTY 250 260 270 280 290 300 LRGSERATAH ARREVLVCSG AIASPQLLQR SGVGPGAWLK ELDIPVVLDL PGVGQNLQDH 310 320 330 340 350 360 LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDLWPN 370 380 390 400 410 420 IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL RSRDPNDHPS ILFNYMAEAL 430 440 450 460 470 480 DWREFRDAIR ATREIMRQPA LDRYRGRELN PGADCKSDKE LDAFVRARAE TAFHPSCSCK 490 500 510 520 530 540 MGYDDMAVVD EEGRVHGLEG LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRKALAR 550 560 VDVPYFVANG AMARNIAKAV RQPETV

References

[1]

"Complete sequence of chromosome 2 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000152 Genomic DNA. Translation: ABB10667.1.
RefSeq	YP_371311.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3752317.
GenomeReviews	Gene locus Bcep18194_B0553 in contig CP000152_GR.
KEGG	bur:Bcep18194_B0553.
NMPDR	fig|269483.3.peg.787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39A44.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_B0553-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_BURS3

Accession

Primary (citable) accession number: Q39A44

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 22, 2005
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)