Reviewed, UniProtKB/Swiss-Prot Q39A43 (BETB_BURS3)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Bcep18194_B0554

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000047040
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	251	1	By similarity
	Active site	285	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39A43-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: FB7040C3C69959CB	FASTA	489	52,326
	10 20 30 40 50 60 MSVFGLQRLY IGGGYVDATS GKTFDTFDPA TGELLAQVQQ ASAADVDRAV ASAQEGQREW 70 80 90 100 110 120 AAMTAMQRSR ILRRAVDLLR ERNDELAALE TRDTGKPIGE TLAVDIVTGA DVIEYYAGLA 130 140 150 160 170 180 TAIEGLQVPL RAESFVYTRR EPLGVCAGIG AWNYPIQIAC WKTAPALAAG NAMVFKPSEV 190 200 210 220 230 240 TPLTALKLAE IYTEAGVPAG VFNVVQGDGS VGALLTGHPD IAKVSFTGGV ETGKKVMSLA 250 260 270 280 290 300 GASSLKEVTM ELGGKSPLIV FDDADLDRAA DIAVTANFFS SGQVCTNGTR VFVHRSIKDA 310 320 330 340 350 360 FTQRVLERVK RIRVGKPTDA DTNFGPLVSA AQLDKVLGFI ESGKAEGAKL LAGGTRLTDG 370 380 390 400 410 420 HFGSGQYVAP TVFGDCRDDM KIVREEIFGP VMSILDFESE DEVIARANDT HYGLAAGVVT 430 440 450 460 470 480 ENLSRAHRTI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGRYNPVF

References

[1]

"Complete sequence of chromosome 2 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000152 Genomic DNA. Translation: ABB10668.1.
RefSeq	YP_371312.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3752318.
GenomeReviews	Gene locus Bcep18194_B0554 in contig CP000152_GR.
KEGG	bur:Bcep18194_B0554.
NMPDR	fig|269483.3.peg.788.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39A43.
OMA	Q39A43. AHRTIHR.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_B0554-MON.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_BURS3

Accession

Primary (citable) accession number: Q39A43

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)