Reviewed, UniProtKB/Swiss-Prot Q39A26 (GLYA1_BURS3)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 1
      Short name=Serine methylase 1
      Short name=SHMT 1
    EC=2.1.2.1

Gene names

Name:	glyA1
Ordered Locus Names:	Bcep18194_B0571

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Serine hydroxymethyltransferase 1 HAMAP MF_00051		PRO_0000234957
Amino acid modifications
	Modified residue	234	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39A26-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 7F1451934ECC5E51	FASTA	424	45,454
	10 20 30 40 50 60 MSNTQPFFSQ PLAERDAPVR SAILKELERQ QSQVELIASE NIVSRAVLEA QGSVLTNKYA 70 80 90 100 110 120 EGYPGKRYYG GCEFADEVEA LAIDRVKQIF NAGYANVQPH SGAQANGSVM LALAKPGDTV 130 140 150 160 170 180 LGMSLDAGGH LTHGAKPALS GKWFNAVQYG VNRDTMLIDY DQVEALAHEH KPNLIIAGFS 190 200 210 220 230 240 AYPRALDFAR FRAIADSVGA KLMVDMAHIA GVIAAGRHAN PVEHAHVVTS TTHKTLRGPR 250 260 270 280 290 300 GGFVLTNDED IAKKINSAVF PGLQGGPLMH VIAGKAVAFG EVLQADFKTY IDNVLANAQA 310 320 330 340 350 360 LGEVLKAGGV DLVTGGTDNH LLLVDLRPKG LKGAPVEQAL ERAGITCNKN GIPFDTEKPT 370 380 390 400 410 420 VTSGIRLGTP AGTTRGFGVA EFREVGRLIL EVFDALRANP EGDHATEQRV RREIFALCER FPIY

References

[1]

"Complete sequence of chromosome 2 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000152 Genomic DNA. Translation: ABB10685.1.
RefSeq	YP_371329.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q39A26.
Genome annotation databases
GeneID	3752335.
GenomeReviews	Gene locus Bcep18194_B0571 in contig CP000152_GR.
KEGG	bur:Bcep18194_B0571.
NMPDR	fig|269483.3.peg.805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39A26.
OMA	FGVAEFR.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_B0571-MON.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA1_BURS3

Accession

Primary (citable) accession number: Q39A26

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)