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Protein

Calnexin homolog

Gene
N/A
Organism
Helianthus tuberosus (Jerusalem artichoke) (Helianthus tomentosus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Calcium; via carbonyl oxygenBy similarity
Metal bindingi69 – 691Calcium; via carbonyl oxygenBy similarity
Binding sitei116 – 1161CarbohydrateBy similarity
Binding sitei118 – 1181CarbohydrateBy similarity
Binding sitei138 – 1381CarbohydrateBy similarity
Binding sitei169 – 1691CarbohydrateBy similarity
Metal bindingi386 – 3861CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calnexin homolog
OrganismiHelianthus tuberosus (Jerusalem artichoke) (Helianthus tomentosus)
Taxonomic identifieri4233 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeHelianthus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 469440LumenalSequence analysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST
Topological domaini491 – 54050CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 540511Calnexin homologPRO_0000004204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 147By similarity
Disulfide bondi311 ↔ 317By similarity
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ39994.

Structurei

3D structure databases

ProteinModelPortaliQ39994.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati229 – 240121-1Add
BLAST
Repeati246 – 257121-2Add
BLAST
Repeati265 – 276121-3Add
BLAST
Repeati284 – 295121-4Add
BLAST
Repeati299 – 309112-1Add
BLAST
Repeati318 – 328112-2Add
BLAST
Repeati332 – 342112-3Add
BLAST
Repeati346 – 356112-4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni227 – 360134P domain (Extended arm)By similarityAdd
BLAST
Regioni229 – 295674 X approximate repeatsAdd
BLAST
Regioni299 – 356584 X approximate repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSRRKMCC YIQFCCFVLI GCFISQICAS SDAIFYESFD ESFEGSWIVS
60 70 80 90 100
EKEDYPGEWK HSKSEGHDDY GLLVSDKARK YAIVKELEKP VELKDGTIVL
110 120 130 140 150
QYEVRLQNGL ECGGAYLKYL RPQDAGWTAK GFDNESPYSI MFGPDKCGAT
160 170 180 190 200
NKVHFILKHK NPKSGDYVEH HLKFPPSVPS DKLTHVYTAV IKPDNELVIL
210 220 230 240 250
IDGEEKKKAN FLSSEDFEPA LIPTKTIPDP DDKKPEDWDE RAKIPDPEAT
260 270 280 290 300
KPDDWDEDAP MEILDEEAEK PEGWLDDEPE EIDDPEAVKP EDWDDEEDGE
310 320 330 340 350
WEAPQIENPK CESAPGCGEW RRPLKRNPAY KGKWHAPLID NPAYKGIWKP
360 370 380 390 400
REIPNPDYFE LEKPNFEPIA AIGIEDLDQQ DGILFDNILI ASDEKTAAKS
410 420 430 440 450
GILLGSRSLR WKKRNRRLKK NQPLLDGLKG IQKAVFDVLY KIADLPFLGD
460 470 480 490 500
HKVKVLELIE KAETQPNITI GVIVSIIVVI FSILLKLLFG GKKAAPKVNV
510 520 530 540
VPKKKEEPEA SNTAEVREGE EEKTEGEVAA APRRRPRRDT
Length:540
Mass (Da):61,274
Last modified:November 1, 1996 - v1
Checksum:iF9A5C4E2DE4A7124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35108 mRNA. Translation: CAA84491.1.
PIRiT10892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35108 mRNA. Translation: CAA84491.1.
PIRiT10892.

3D structure databases

ProteinModelPortaliQ39994.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ39994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALX_HELTU
AccessioniPrimary (citable) accession number: Q39994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.