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Protein

Calnexin homolog

Gene
N/A
Organism
Helianthus tuberosus (Jerusalem artichoke) (Helianthus tomentosus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Calcium; via carbonyl oxygenBy similarity1
Metal bindingi69Calcium; via carbonyl oxygenBy similarity1
Binding sitei116CarbohydrateBy similarity1
Binding sitei118CarbohydrateBy similarity1
Binding sitei138CarbohydrateBy similarity1
Binding sitei169CarbohydrateBy similarity1
Metal bindingi386CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calnexin homolog
OrganismiHelianthus tuberosus (Jerusalem artichoke) (Helianthus tomentosus)
Taxonomic identifieri4233 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeHelianthus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 469LumenalSequence analysisAdd BLAST440
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 540CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000420430 – 540Calnexin homologAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 147By similarity
Disulfide bondi311 ↔ 317By similarity
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ39994.

Structurei

3D structure databases

ProteinModelPortaliQ39994.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati229 – 2401-1Add BLAST12
Repeati246 – 2571-2Add BLAST12
Repeati265 – 2761-3Add BLAST12
Repeati284 – 2951-4Add BLAST12
Repeati299 – 3092-1Add BLAST11
Repeati318 – 3282-2Add BLAST11
Repeati332 – 3422-3Add BLAST11
Repeati346 – 3562-4Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 360P domain (Extended arm)By similarityAdd BLAST134
Regioni229 – 2954 X approximate repeatsAdd BLAST67
Regioni299 – 3564 X approximate repeatsAdd BLAST58

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSRRKMCC YIQFCCFVLI GCFISQICAS SDAIFYESFD ESFEGSWIVS
60 70 80 90 100
EKEDYPGEWK HSKSEGHDDY GLLVSDKARK YAIVKELEKP VELKDGTIVL
110 120 130 140 150
QYEVRLQNGL ECGGAYLKYL RPQDAGWTAK GFDNESPYSI MFGPDKCGAT
160 170 180 190 200
NKVHFILKHK NPKSGDYVEH HLKFPPSVPS DKLTHVYTAV IKPDNELVIL
210 220 230 240 250
IDGEEKKKAN FLSSEDFEPA LIPTKTIPDP DDKKPEDWDE RAKIPDPEAT
260 270 280 290 300
KPDDWDEDAP MEILDEEAEK PEGWLDDEPE EIDDPEAVKP EDWDDEEDGE
310 320 330 340 350
WEAPQIENPK CESAPGCGEW RRPLKRNPAY KGKWHAPLID NPAYKGIWKP
360 370 380 390 400
REIPNPDYFE LEKPNFEPIA AIGIEDLDQQ DGILFDNILI ASDEKTAAKS
410 420 430 440 450
GILLGSRSLR WKKRNRRLKK NQPLLDGLKG IQKAVFDVLY KIADLPFLGD
460 470 480 490 500
HKVKVLELIE KAETQPNITI GVIVSIIVVI FSILLKLLFG GKKAAPKVNV
510 520 530 540
VPKKKEEPEA SNTAEVREGE EEKTEGEVAA APRRRPRRDT
Length:540
Mass (Da):61,274
Last modified:November 1, 1996 - v1
Checksum:iF9A5C4E2DE4A7124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35108 mRNA. Translation: CAA84491.1.
PIRiT10892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35108 mRNA. Translation: CAA84491.1.
PIRiT10892.

3D structure databases

ProteinModelPortaliQ39994.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ39994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALX_HELTU
AccessioniPrimary (citable) accession number: Q39994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.