Reviewed, UniProtKB/Swiss-Prot Q39839 (NDK1_SOYBN)

Names and origin

Protein names	Recommended name:     Nucleoside diphosphate kinase 1     EC=2.7.4.6 Alternative name(s):     Nucleoside diphosphate kinase I       Short name=NDP kinase I       Short name=NDPK I       Short name=NDK I
Organism	Glycine max (Soybean)
Taxonomic identifier	3847 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Nucleoside diphosphate kinase 1		PRO_0000137144
Sites
	Active site	116	1	Pros-phosphohistidine intermediate By similarity
	Binding site	10	1	ATP By similarity
	Binding site	58	1	ATP By similarity
	Binding site	86	1	ATP By similarity
	Binding site	92	1	ATP By similarity
	Binding site	103	1	ATP By similarity
	Binding site	113	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39839-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0177E3B21028D033	FASTA	149	16,443
	10 20 30 40 50 60 MDEQTFIMIK PDGVQRGLIG EIISRFEKKG FYLKGLKLVT VDRPFAEKHY ADLSAKPFFS 70 80 90 100 110 120 GLVDYIISGP VVAMIWEGKN VVTTGRKIIG ATNPAQSEPG TIRGDFAIDI GRNVIHGSDA 130 140 VESANKEIAL WFPEGPANCQ SSQHSWIYE

References

[1]	Krishnan H.B., Karr D.B., Emerich D.W. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Williams 82.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U50150 mRNA. Translation: AAA93030.1.
PIR	T07042.
UniGene	Gma.9551
3D structure databases
SMR	Q39839. Positions 3-149.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.4.6. 299.
Gene expression databases
Genevestigator	Q39839.
Family and domain databases
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK1_SOYBN

Accession

Primary (citable) accession number: Q39839

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)