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Protein

Albumin-1

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A1b binds to basic 7S globulin (BG) and stimulates its phosphorylation activity. Involved in the signal transduction system to regulate the growth and differentiation as a hormone peptide.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSeed storage protein, Storage protein, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Albumin-1
Short name:
A1
Cleaved into the following 2 chains:
Albumin-1 chain b
Short name:
A1b
Alternative name(s):
Leginsulin
Albumin-1 chain a
Short name:
A1a
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35R → A: No effect. 1 Publication1
Mutagenesisi48V → A: Decreased binding to globulin. 1 Publication1
Mutagenesisi50F → A: Decreased binding to globulin. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003225220 – 56Albumin-1 chain bAdd BLAST37
PropeptideiPRO_000003225357 – 64Sequence analysis8
ChainiPRO_000003225465 – 116Albumin-1 chain aSequence analysisAdd BLAST52
PropeptideiPRO_0000032255117 – 119Sequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 39
Disulfide bondi26 ↔ 41
Disulfide bondi34 ↔ 51

Post-translational modificationi

The C-terminal glycine may be removed from A1b.

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA13G26340.1.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 26Combined sources3
Beta strandi28 – 35Combined sources8
Beta strandi39 – 43Combined sources5
Beta strandi45 – 47Combined sources3
Beta strandi49 – 52Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JU8NMR-A20-56[»]
ProteinModelPortaliQ39837.
SMRiQ39837.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ39837.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR012512. Albumin_I.
IPR032000. Albumin_I_a.
PfamiView protein in Pfam
PF08027. Albumin_I. 1 hit.
PF16720. Albumin_I_a. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFLLATST IMFPTKIEAA DCNGACSPFE VPPCRSRDCR CVPIGLFVGF
60 70 80 90 100
CIHPTGLSSV AKMIDEHPNL CQSDDECMKK GSGNFCARYP NNYIDYGWCF
110
DSDSEALKGF LAMPRATTK
Length:119
Mass (Da):13,046
Last modified:July 11, 2001 - v3
Checksum:iA054491D7BE1AA70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17396 mRNA. Translation: BAA04219.1.
AJ223037 Genomic DNA. Translation: CAA11040.1.
PIRiS48192.
RefSeqiNP_001237714.1. NM_001250785.1.
UniGeneiGma.188.

Genome annotation databases

GeneIDi547776.
KEGGigmx:547776.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiALB1_SOYBN
AccessioniPrimary (citable) accession number: Q39837
Secondary accession number(s): O49854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 11, 2001
Last modified: November 2, 2016
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references