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Protein

Acetaldehyde dehydrogenase 1

Gene

Bcep18194_B1187

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Acyl-thioester intermediateUniRule annotation1
Binding sitei287NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 168NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:Bcep18194_B1187
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876381 – 319Acetaldehyde dehydrogenase 1Add BLAST319

Structurei

3D structure databases

ProteinModelPortaliQ397R0.
SMRiQ397R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OMAiTSAYVHK.
OrthoDBiPOG091H09NP.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q397R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSKAKVAII GPGNIGTDLM IKVMRHGTHI EMGAMIGVDP KSDGLARAQR
60 70 80 90 100
MGVAISSDGI DGLLALDVFK EIDIVFDATS AGAHKRHNDV LQAHGVQVID
110 120 130 140 150
LTPAAIGPYV IPAINLESEN APNMNMVTCG GQATIPMVAA ISRVTKVHYA
160 170 180 190 200
EIVASISSKS AGPGTRANID EFTETTRKAI EQLGGASRGK AIIILNPAEP
210 220 230 240 250
PLIMRDTVFA LSDPADQGKI EDSIAQMVAS VQAYVPGYRL KQKVQFDVIT
260 270 280 290 300
ADKPLNVPGV GLKHGLKTSV FLEVEGAAHY LPSYAGNLDI MTSAALACGD
310
MMARRRMAAG IARGHKEAV
Length:319
Mass (Da):33,598
Last modified:November 22, 2005 - v1
Checksum:i0FA1226DA8DA9FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA. Translation: ABB11301.1.

Genome annotation databases

EnsemblBacteriaiABB11301; ABB11301; Bcep18194_B1187.
KEGGibur:Bcep18194_B1187.
PATRICifig|482957.22.peg.4857.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH1_BURL3
AccessioniPrimary (citable) accession number: Q397R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families