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Q396N9

- ACDH2_BURS3

UniProt

Q396N9 - ACDH2_BURS3

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Protein
Acetaldehyde dehydrogenase 2
Gene
Bcep18194_B1458
Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediate By similarity
Binding sitei272 – 2721NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSP269483:GHLS-4877-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:Bcep18194_B1458
OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002705: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Acetaldehyde dehydrogenase 2UniRule annotation
PRO_0000387639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269483.Bcep18194_B1458.

Structurei

3D structure databases

ProteinModelPortaliQ396N9.
SMRiQ396N9. Positions 2-294.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiDIQQYVP.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q396N9-1 [UniParc]FASTAAdd to Basket

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MKKIKCALIG PGNIGTDLLY KLRRSTVLEP VWMVGVDPAS DGLARAREFG    50
LKTTDKGVDG LLPHVAADEI RIAFDATSAY VHRDNSDKLT ALGVKMIDLT 100
PAAIGPYCVP PVNLDAHLDS AQTNVNMVTC GGQATIPMVY AVSRVQPVAY 150
GEIVATVSSR SVGPGTRKNI DEFTRTTSGA IEQVGGARKG KAIIVINPAE 200
PPLIMRDTIH CLTDGPPDVD AITASVHAMV KEVQRYVPGY TLKNGPVFDG 250
NRVSVFMEVE GLGDYLPKYA GNLDIMTAAA AATAERFAEQ MLAATAATA 299
Length:299
Mass (Da):31,651
Last modified:November 22, 2005 - v1
Checksum:iCA82D30B3424609A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000152 Genomic DNA. Translation: ABB11572.1.
RefSeqiWP_011355061.1. NC_007511.1.
YP_372216.1. NC_007511.1.

Genome annotation databases

EnsemblBacteriaiABB11572; ABB11572; Bcep18194_B1458.
GeneIDi3753223.
KEGGibur:Bcep18194_B1458.
PATRICi19293707. VBIBurSp120713_6216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000152 Genomic DNA. Translation: ABB11572.1 .
RefSeqi WP_011355061.1. NC_007511.1.
YP_372216.1. NC_007511.1.

3D structure databases

ProteinModelPortali Q396N9.
SMRi Q396N9. Positions 2-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269483.Bcep18194_B1458.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB11572 ; ABB11572 ; Bcep18194_B1458 .
GeneIDi 3753223.
KEGGi bur:Bcep18194_B1458.
PATRICi 19293707. VBIBurSp120713_6216.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi DIQQYVP.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BSP269483:GHLS-4877-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 383.

Entry informationi

Entry nameiACDH2_BURS3
AccessioniPrimary (citable) accession number: Q396N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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