Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a

Gene
N/A
Organism
Cucumis sativus (Cucumber)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.1 Publication
A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.1 Publication
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.1 Publication
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.1 Publication
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.1 Publication

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

  • 3-hydroxyacyl-CoA dehydratase activity Source: UniProtKB
  • 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
  • 3-hydroxybutyryl-CoA epimerase activity Source: UniProtKB
  • dodecenoyl-CoA delta-isomerase activity Source: UniProtKB
  • enoyl-CoA hydratase activity Source: UniProtKB

GO - Biological processi

  • fatty acid beta-oxidation Source: UniProtKB

Keywordsi

Molecular functionIsomerase, Lyase, Multifunctional enzyme, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a
Including the following 2 domains:
Enoyl-CoA hydratase/3-2-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC:4.2.1.17, EC:5.1.2.3, EC:5.3.3.8)
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
OrganismiCucumis sativus (Cucumber)Imported
Taxonomic identifieri3659 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCucumis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001092511 – 725Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-aAdd BLAST725

Proteomic databases

PRIDEiQ39659

Structurei

3D structure databases

ProteinModelPortaliQ39659
SMRiQ39659
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The epimerase and isomerase activities are contained in the N-terminal region while the dehydrogenase activity is in the C-terminal region.1 Publication

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated

Phylogenomic databases

KOiK10527

Family and domain databases

InterProiView protein in InterPro
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF00378 ECH_1, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q39659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNAKGRTV MEVGTDGVAI ITIINPPVNS LSFDVLFSLR DSYEQALRRD
60 70 80 90 100
DVKAIVVTGA KGKFSGGFDI TAFGVLQGGK GEQPNVRNIS IEMITDIFEA
110 120 130 140 150
ARKPAVAAID GLALGGGLEV AMACHARIST PTAQLGLPEL QLGIIPGFGG
160 170 180 190 200
TQRLPRLVGL SKALEMMLTS KPIKGQEAHS LGLVDAIVPP EELINTARRW
210 220 230 240 250
ALEILERRRP WVHSLHRTDK LESLAEARKI FNLARAQAKK QYPNLKHTIA
260 270 280 290 300
CIDAVETGVV SGPRAGLWKE AEEFQGLLHS DTCKSLIHIF FAQRSTTKVP
310 320 330 340 350
GVTDLGLVPR QIKKVAIVGG GLMGSGIATA LILSNYHVVL KEVNDKFLQA
360 370 380 390 400
GIDRVRANLQ SRVKKGNMTN EKFEKSISLL KGVLNYESFK DVDMVIEAVI
410 420 430 440 450
ENVSLKQQIF SDLEKYCPPH CMLATNTSTI DLELIGERIK SRDRIIGAHF
460 470 480 490 500
FSPAHIMPLL EIVRTKHTAA QVIVDLLDVG KNIKKTPVVV GNCTGFAVNR
510 520 530 540 550
MFFPYSQAAI LLAEHGVDPY QIDRAISKFG MPMGPFRLCD LVGFGVAAAT
560 570 580 590 600
ASQFVQAFPE RTYKSMLIPL MQEDKNAGES TRKGFYVYDK NRKAGPNPEL
610 620 630 640 650
KKYIEKARNS SGVSVDPKLT KLPEKDIVEM IFFPVVNEAC RVLAEGIAVK
660 670 680 690 700
AADLDIAGVM GMGFPSYRGG LMFWADSLGS NYIYSRLEEW SKQYGGFFKP
710 720
CGYLAERAVQ GATLSAPGGH AKPRM
Length:725
Mass (Da):79,170
Last modified:November 1, 1996 - v1
Checksum:iD7C7943A51AFE7DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78996 mRNA Translation: CAA55630.1
PIRiT10464
RefSeqiNP_001292693.1, NM_001305764.1

Genome annotation databases

EnsemblPlantsiKGN47371; KGN47371; Csa_6G306330
GeneIDi101210295
GrameneiKGN47371; KGN47371; Csa_6G306330
KEGGicsv:101210295

Similar proteinsi

Entry informationi

Entry nameiMFPA_CUCSA
AccessioniPrimary (citable) accession number: Q39659
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health