Q39613 (CYPH_CATRO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Cyclophilin
Cyclosporin A-binding protein
Rotamase

Gene names

Name:

PCKR1

Organism

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

Taxonomic identifier

4058 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Gentianales › Apocynaceae › Rauvolfioideae › Vinceae › Catharanthus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Cyclosporin
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide binding Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Peptidyl-prolyl cis-trans isomerase		PRO_0000064143
Regions
	Domain	7 – 170	164	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	Q39613 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EA6EC51886A50A81	FASTA	172	18,285
	10 20 30 40 50 60 MPNPRVFFDM SVGGQPAGRI VMELFADTTP RTAENFRALC TGEKGTGRSG KPLHYKDSSF 70 80 90 100 110 120 HRVIPGFMCQ GGDFTAGNGT GGESIYGAKF ADENFIKKHT GPGILSMANA GPNTNGSQFF 130 140 150 160 170 ICTAKTEWLD GKHVVFGQVV EGMDVVKAIE KVGSSSGRTA KKVVVEDCGQ LS

References

[1]	"Isolation of a full-length cDNA encoding a cytosolic cyclophilin from Periwinkle (Catharanthus roseus)." Clastre M., Maaroufi H., Andreu F., Chenieux J.-C., Rideau M., Hamdi S. Plant Gene Register PGR95-100 Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85185 mRNA. Translation: CAA59468.1.
PIR	T10056.
3D structure databases
ProteinModelPortal	Q39613.
SMR	Q39613. Positions 1-172.
ModBase	Search...
Protein family/group databases
Allergome	2900. Cat r 1. 3181. Cat r 1.0101.
Proteomic databases
PRIDE	Q39613.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PIRSF	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYPH_CATRO

Accession

Primary (citable) accession number: Q39613

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program