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Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene

GSA

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (HemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayi: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processChlorophyll biosynthesis, Porphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317
UPA00668

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:GSA
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30ChloroplastSequence analysisAdd BLAST30
ChainiPRO_000000125731 – 463Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei303N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ39566
ProMEXiQ39566

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ39566
SMRiQ39566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IPFV Eukaryota
COG0001 LUCA
KOiK01845
OMAiWGPLIFG

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMQLNAKTV QGAFKAQRPR SVRGNVAVRA VAAPPKLVTK RSEEIFKEAQ
60 70 80 90 100
ELLPGGVNSP VRAFRSVGGG PIVFDRVKGA YCWDVDGNKY IDYVGSWGPA
110 120 130 140 150
ICGHGNDEVN NALKAQIDKG TSFGAPCELE NVLAKMVIDR VPSVEMVRFV
160 170 180 190 200
SSGTEACLSV LRLMRAYTGR EKVLKFTGCY HGHADSFLVK AGSGVITLGL
210 220 230 240 250
PDSPGVPKST AAATLTATYN NLDSVRELFA ANKGEIAGVI LEPVVGNSGF
260 270 280 290 300
IVPTKEFLQG LREICTAEGA VLCFDEVMTG FRIAKGCAQE HFGITPDLTT
310 320 330 340 350
MGKVIGGGMP VGAYGGKKEI MKMVAPAGPM YQAGTLSGNP MAMTAGIKTL
360 370 380 390 400
EILGRPGAYE HLEKVTKRLI DGIMAAAKEH SHEITGGNIS GMFGFFFCKG
410 420 430 440 450
PVTCFEDALA ADTAKFARFH RGMLEEGVYL APSQFEAGFT SLAHSEADVD
460
ATIAAARRVF ARI
Length:463
Mass (Da):49,228
Last modified:November 1, 1997 - v1
Checksum:i9CB3BDF9A90C8010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03632 mRNA Translation: AAA18861.1
U03633 Unassigned DNA Translation: AAA18862.1
PIRiS43787
RefSeqiXP_001697519.1, XM_001697467.1
UniGeneiCre.13379

Genome annotation databases

EnsemblPlantsiEDP00181; EDP00181; CHLREDRAFT_138524
GeneIDi5723033
GrameneiEDP00181; EDP00181; CHLREDRAFT_138524
KEGGicre:CHLREDRAFT_138524

Similar proteinsi

Entry informationi

Entry nameiGSA_CHLRE
AccessioniPrimary (citable) accession number: Q39566
Secondary accession number(s): Q39567
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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