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Q39566

- GSA_CHLRE

UniProt

Q39566 - GSA_CHLRE

Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene

GSA

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
    Short name:
    GSA
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase
    Short name:
    GSA-AT
    Gene namesi
    Name:GSA
    OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
    Taxonomic identifieri3055 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: EnsemblPlants/Gramene
    2. chloroplast envelope Source: EnsemblPlants/Gramene
    3. chloroplast stroma Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030ChloroplastSequence AnalysisAdd
    BLAST
    Chaini31 – 463433Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticPRO_0000001257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei303 – 3031N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ39566.
    ProMEXiQ39566.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ39566.
    SMRiQ39566. Positions 39-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0001.
    KOiK01845.
    OMAiRAIKPYP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q39566-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQMQLNAKTV QGAFKAQRPR SVRGNVAVRA VAAPPKLVTK RSEEIFKEAQ    50
    ELLPGGVNSP VRAFRSVGGG PIVFDRVKGA YCWDVDGNKY IDYVGSWGPA 100
    ICGHGNDEVN NALKAQIDKG TSFGAPCELE NVLAKMVIDR VPSVEMVRFV 150
    SSGTEACLSV LRLMRAYTGR EKVLKFTGCY HGHADSFLVK AGSGVITLGL 200
    PDSPGVPKST AAATLTATYN NLDSVRELFA ANKGEIAGVI LEPVVGNSGF 250
    IVPTKEFLQG LREICTAEGA VLCFDEVMTG FRIAKGCAQE HFGITPDLTT 300
    MGKVIGGGMP VGAYGGKKEI MKMVAPAGPM YQAGTLSGNP MAMTAGIKTL 350
    EILGRPGAYE HLEKVTKRLI DGIMAAAKEH SHEITGGNIS GMFGFFFCKG 400
    PVTCFEDALA ADTAKFARFH RGMLEEGVYL APSQFEAGFT SLAHSEADVD 450
    ATIAAARRVF ARI 463
    Length:463
    Mass (Da):49,228
    Last modified:November 1, 1997 - v1
    Checksum:i9CB3BDF9A90C8010
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03632 mRNA. Translation: AAA18861.1.
    U03633 Unassigned DNA. Translation: AAA18862.1.
    PIRiS43787.
    RefSeqiXP_001697519.1. XM_001697467.1.
    UniGeneiCre.13379.

    Genome annotation databases

    GeneIDi5723033.
    KEGGicre:CHLREDRAFT_138524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03632 mRNA. Translation: AAA18861.1 .
    U03633 Unassigned DNA. Translation: AAA18862.1 .
    PIRi S43787.
    RefSeqi XP_001697519.1. XM_001697467.1.
    UniGenei Cre.13379.

    3D structure databases

    ProteinModelPortali Q39566.
    SMRi Q39566. Positions 39-463.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q39566.
    ProMEXi Q39566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5723033.
    KEGGi cre:CHLREDRAFT_138524.

    Phylogenomic databases

    eggNOGi COG0001.
    KOi K01845.
    OMAi RAIKPYP.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and light-regulated expression of the gsa gene encoding the chlorophyll biosynthetic enzyme, glutamate 1-semialdehyde aminotransferase, in Chlamydomonas reinhardtii."
      Matters G.L., Beale S.I.
      Plant Mol. Biol. 24:617-629(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NO-.

    Entry informationi

    Entry nameiGSA_CHLRE
    AccessioniPrimary (citable) accession number: Q39566
    Secondary accession number(s): Q39567
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3