Bcep18194_B1965

Functionⁱ

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityⁱ

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactorⁱ

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayⁱ: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Alanine racemase (WJ23_10985), Alanine racemase (Bcep18194_A5348), Alanine racemase (Bcep18194_B1965), Alanine racemase (VL00_18935), Alanine racemase (VL00_21010), Alanine racemase (WI95_21695), Alanine racemase (WJ23_27545)

This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	35	Proton acceptor; specific for D-alanineUniRule annotation	1
Binding siteⁱ	130	SubstrateUniRule annotation	1
Active siteⁱ	252	Proton acceptor; specific for L-alanineUniRule annotation	1
Binding siteⁱ	300	Substrate; via amide nitrogenUniRule annotation	1

GO - Molecular functionⁱ

alanine racemase activity Source: UniProtKB-HAMAP
pyridoxal phosphate binding Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

D-alanine biosynthetic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	IsomeraseUniRule annotationSAAS annotationImported
Ligand	Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00042; UER00497.

UniPathwayⁱ

UPA00042; UER00497.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesⁱ	Ordered Locus Names:Bcep18194_B1965Imported
Organismⁱ	Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)Imported
Taxonomic identifierⁱ	482957 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex
Proteomesⁱ	UP000002705 Componentⁱ: Chromosome 2

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	35	N6-(pyridoxal phosphate)lysineUniRule annotation		1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q394N8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	231 – 355	Ala_racemase_CInterPro annotationAdd BLAST		125

Sequence similaritiesⁱ

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMⁱ	HOG000031446.
KEGG Orthology (KO) More...KOⁱ	K01775.
OMAⁱ	ISHFACA.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H022F.

Family and domain databases

Gene3Dⁱ	2.40.37.10. 1 hit. 3.20.20.10. 1 hit.
HAMAPⁱ	MF_01201. Ala_racemase. 1 hit.
InterProⁱ	View protein in InterPro IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. IPR029066. PLP-binding_barrel.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit.
PRINTSⁱ	PR00992. ALARACEMASE.
SMARTⁱ	View protein in SMART SM01005. Ala_racemase_C. 1 hit.
SUPFAMⁱ	SSF50621. SSF50621. 1 hit. SSF51419. SSF51419. 1 hit.
TIGRFAMsⁱ	TIGR00492. alr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00395. ALANINE_RACEMASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q394N8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRPIVAHIR PDAVRHNLDF IRRTAAQSRV WGVVKADAYG HGIERIYPGL 
        60         70         80         90        100
AAADGIALLD LDEAVRVREL GWDKPVLLLE GIFEPADVEL ADRHRLTVAV 
       110        120        130        140        150
HCDEQLDLLI AARPQQPIDI QLKMNSGMNR LGYRPAAFRA AWERAASAPS 
       160        170        180        190        200
IGKITLMMHF ANADEGEVDW QLDQFDATTA GIPGERSTSN SAAVLWHPRA 
       210        220        230        240        250
HRDWVRPGTI LYGASPTGAA RDIADTPLMA AMTLTSKIIG VQTLSPEETV 
       260        270        280        290        300
GYGRRFTADR PMRIGVVACG YADGYPRHAP TGTPIAVDGV MTRVVGRVSM 
       310        320        330        340        350
DMLTVDLTPC PNAGIGSSVE LWGDQVKVDD VAEASGTIGY ELMCALARRV 
       360        370 
PVVIVPPGAS SEQPTLRTGS YGR

Length:373

Mass (Da):40,326

Last modified:November 22, 2005 - v1

Checksum:ⁱ96D98CB104437B8D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000152 Genomic DNA. Translation: ABB12078.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011355562.1. NC_007511.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABB12078; ABB12078; Bcep18194_B1965.
KEGGⁱ	bur:Bcep18194_B1965.
PATRICⁱ	fig\|482957.22.peg.5708.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000152 Genomic DNA. Translation: ABB12078.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011355562.1. NC_007511.1.

3D structure databases

ProteinModelPortalⁱ	Q394N8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABB12078; ABB12078; Bcep18194_B1965.
KEGGⁱ	bur:Bcep18194_B1965.
PATRICⁱ	fig\|482957.22.peg.5708.

Phylogenomic databases

HOGENOMⁱ	HOG000031446.
KEGG Orthology (KO) More...KOⁱ	K01775.
OMAⁱ	ISHFACA.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H022F.

Enzyme and pathway databases

UniPathwayⁱ	UPA00042; UER00497.

UniPathwayⁱ

UPA00042; UER00497.

Family and domain databases

Gene3Dⁱ	2.40.37.10. 1 hit. 3.20.20.10. 1 hit.
HAMAPⁱ	MF_01201. Ala_racemase. 1 hit.
InterProⁱ	View protein in InterPro IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. IPR029066. PLP-binding_barrel.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit.
PRINTSⁱ	PR00992. ALARACEMASE.
SMARTⁱ	View protein in SMART SM01005. Ala_racemase_C. 1 hit.
SUPFAMⁱ	SSF50621. SSF50621. 1 hit. SSF51419. SSF51419. 1 hit.
TIGRFAMsⁱ	TIGR00492. alr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00395. ALANINE_RACEMASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q394N8_BURL3
Accessionⁱ	Q394N8Primary (citable) accession number: Q394N8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 22, 2005
	Last sequence update:	November 22, 2005
	Last modified:	June 7, 2017
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - Q394N8 (Q394N8_BURL3)

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Alanine racemase

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Functionⁱ

Catalytic activityⁱ

Cofactorⁱ

Pathwayⁱ: D-alanine biosynthesis

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Amino acid modifications

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q394N8 (Q394N8_BURL3)

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Alanine racemase

Bcep18194_B1965

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: D-alanine biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: D-alanine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ