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Q39491 (PTP3_CHLMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:VH-PTP13
OrganismChlamydomonas moewusii (Chlamydomonas eugametos)
Taxonomic identifier3054 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be involved in tyrosine phosphatase signalling pathways, having MAP-kinases as substrates.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Developmental stage

Non-dividing gametes did not express the VH-PTP13 gene whereas synchronously dividing vegetative cells only expressed VH-PTP13 in the early G1-phase of the cycle.

Induction

By oxidative stress.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Dual specificity protein phosphatase
PRO_0000094873

Regions

Region89 – 276188Catalytic

Sites

Active site1721Phosphocysteine intermediate

Experimental info

Mutagenesis1721C → S: Complete loss of activity. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q39491 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 034EF63951E03381

FASTA27630,310
        10         20         30         40         50         60 
MTSHAANPKE EQDQRLPFKS DISGPIAPSQ APAHTVQAHD SQPKPSDDSS DEHLSFYEAK 

        70         80         90        100        110        120 
ARIVRAFAAS RAPQPAAPAA KALEGDASVI VPGKLILSSC EVEESSELLT KLGVTHILQV 

       130        140        150        160        170        180 
GEELKPSHPG RFTYLSLPIL DMEGQDIVAL LPSCFQFLQQ AQASGGVCLV HCLAGISRSA 

       190        200        210        220        230        240 
SVVIAYLMWT QGMPYTEARA MVRRARSKVY PNTGFTLQLQ ELDRLRESGA IQWGDTPSLA 

       250        260        270 
SSLEQHRQPW NLIRYLEVKE KQAQEEGWTW GRTLVI 

« Hide

References

[1]"Tyrosine phosphatase signalling in a lower plant: cell-cycle and oxidative stress-regulated expression of the Chlamydomonas eugametos VH-PTP13 gene."
Haring M.A., Siderius M., Jonak C., Hirt H., Walton K.M., Musgrave A.
Plant J. 7:981-988(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, MUTAGENESIS OF CYS-172.
Strain: UTEX 10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77938 mRNA. Translation: CAA54910.1.
PIRT48906.

3D structure databases

ProteinModelPortalQ39491.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTP3_CHLMO
AccessionPrimary (citable) accession number: Q39491
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families