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Protein

ATP-dependent zinc metalloprotease FTSH, chloroplastic

Gene

FTSH

Organism
Capsicum annuum (Bell pepper)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to act as an ATP-dependent zinc metallopeptidase.By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi492Zinc; catalyticBy similarity1
Active sitei493By similarity1
Metal bindingi496Zinc; catalyticBy similarity1
Metal bindingi573Zinc; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi270 – 277ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCell cycle, Cell division
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiM41.005

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FTSH, chloroplastic (EC:3.4.24.-)
Gene namesi
Name:FTSH
OrganismiCapsicum annuum (Bell pepper)
Taxonomic identifieri4072 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeCapsiceaeCapsicum
Proteomesi
  • UP000189700 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000245? – 662ATP-dependent zinc metalloprotease FTSH, chloroplastic
Transit peptidei‹1 – ?ChloroplastSequence analysis

Proteomic databases

PRIDEiQ39444

Structurei

3D structure databases

ProteinModelPortaliQ39444
SMRiQ39444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KYFNFHSKRK CIITQSTLNK KPNSDNFKNA QSKAALAALL FSSITPHAIA
60 70 80 90 100
LDDAAPIASP PQVMEVEAPN PNTSNPLPFS QNLVLNAPKT QASPVSDLPE
110 120 130 140 150
STQWRYSEFL NAVKKGKVER VRFSKDGSAL QLTAVDGRRA NVIVPNDPDL
160 170 180 190 200
IDILAMNGVD ISVSEGEGGN GLFSVIGNLL FPFIAFAGLF FLFRRSQGGP
210 220 230 240 250
GGPGGLGGPM DFGRSKSKFQ EVPETGVTFA DVAGADQAKL ELQEVVDFLK
260 270 280 290 300
NPDKYTALGA KIPKGCLLVG PPGTGKTLLA RAVAGEAGVP FFSCAASEFV
310 320 330 340 350
ELFVGVGASR VRHLFENAKS KAPCIVFIDE IDAVGRQRGA GLGGGNDERE
360 370 380 390 400
QTINQLLTEM DGFSGNSGVI VLAATNRPDV LDSALLRPGK FDRQVTVDRP
410 420 430 440 450
DVAGRVRILQ VHSRGKALAK DVDFDKIARR TPGFTGADLQ NLMNEAAILA
460 470 480 490 500
ARRDLKEISK DEISDALERI IAGPEKKNAV VSDEKKKLVA YHEAGHALVG
510 520 530 540 550
ALMPEYDPVA KISIIPRGQA GGLTFFAPSE ERLESGLYSR SYLENQMAVA
560 570 580 590 600
LGGRVAEEVI FGEDNVTTGA SNDFMQVSRV ARQMVERLGF SKKIGQVAIG
610 620 630 640 650
GGGGNPFLGQ QMSTQKDYSM ATADVVDSEV RELVEKAYER AKQIITTHID
660
ILHKLAQLLI EK
Length:662
Mass (Da):71,061
Last modified:November 1, 1996 - v1
Checksum:iAF3411BDC502C6A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei6621

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90472 mRNA Translation: CAA62084.1
PIRiS58298
UniGeneiCan.3495

Similar proteinsi

Entry informationi

Entry nameiFTSH_CAPAN
AccessioniPrimary (citable) accession number: Q39444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health