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Q39419

- POLC4_BETPN

UniProt

Q39419 - POLC4_BETPN

Protein

Polcalcin Bet v 4

Gene

BETV4

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 31121Add
    BLAST
    Calcium bindingi55 – 66122Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polcalcin Bet v 4
    Alternative name(s):
    Calcium-binding pollen allergen Bet v 4
    Allergen: Bet v 4
    Gene namesi
    Name:BETV4
    OrganismiBetula pendula (European white birch) (Betula verrucosa)
    Taxonomic identifieri3505 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei129. Bet v 4.
    3138. Bet v 4.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8585Polcalcin Bet v 4PRO_0000073666Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    MINTiMINT-7718600.

    Structurei

    Secondary structure

    1
    85
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1914
    Beta strandi24 – 274
    Helixi29 – 368
    Helixi37 – 393
    Helixi44 – 5411
    Helixi64 – 7310
    Helixi75 – 8410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1H4BNMR-A2-85[»]
    ProteinModelPortaliQ39419.
    SMRiQ39419. Positions 2-85.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ39419.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 4236EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini42 – 7736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF00036. EF-hand_1. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39419-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDHPQDKA ERERIFKRFD ANGDGKISAA ELGEALKTLG SITPDEVKHM   50
    MAEIDTDGDG FISFQEFTDF GRANRGLLKD VAKIF 85
    Length:85
    Mass (Da):9,448
    Last modified:November 1, 1996 - v1
    Checksum:iE2FC882E5BB8ADFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711G → A in CAA73147. (PubMed:9345295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87153 mRNA. Translation: CAA60628.1.
    Y12560 mRNA. Translation: CAA73147.1.
    PIRiJC5711.
    S54819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87153 mRNA. Translation: CAA60628.1 .
    Y12560 mRNA. Translation: CAA73147.1 .
    PIRi JC5711.
    S54819.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1H4B NMR - A 2-85 [» ]
    ProteinModelPortali Q39419.
    SMRi Q39419. Positions 2-85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-7718600.

    Protein family/group databases

    Allergomei 129. Bet v 4.
    3138. Bet v 4.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q39419.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF00036. EF-hand_1. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains."
      Engel E., Richter K., Obermeyer G., Briza P., Kungl A.J., Simon B., Auer M., Ebner C., Rheinberger H.J., Breitenbach M., Ferreira F.
      J. Biol. Chem. 272:28630-28637(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.
    2. "Molecular characterization, expression in Escherichia coli, and epitope analysis of a two EF-hand calcium-binding birch pollen allergen, Bet v 4."
      Twardosz A., Hayek B., Seiberler S., Pastore A., Vangelista L., Groenlund H., Kraft D., Valenta R.
      Biochem. Biophys. Res. Commun. 239:197-204(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.
    3. "Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function."
      Neudecker P., Nerkamp J., Eisenmann A., Nourse A., Lauber T., Schweimer K., Lehmann K., Schwarzinger S., Ferreira F., Rosch P.
      J. Mol. Biol. 336:1141-1157(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 2-85, SUBUNIT.

    Entry informationi

    Entry nameiPOLC4_BETPN
    AccessioniPrimary (citable) accession number: Q39419
    Secondary accession number(s): O04131
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3