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Q39419

- POLC4_BETPN

UniProt

Q39419 - POLC4_BETPN

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Protein

Polcalcin Bet v 4

Gene

BETV4

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 31121Add
BLAST
Calcium bindingi55 – 66122Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polcalcin Bet v 4
Alternative name(s):
Calcium-binding pollen allergen Bet v 4
Allergen: Bet v 4
Gene namesi
Name:BETV4
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei129. Bet v 4.
3138. Bet v 4.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Polcalcin Bet v 4PRO_0000073666Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

MINTiMINT-7718600.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1914
Beta strandi24 – 274
Helixi29 – 368
Helixi37 – 393
Helixi44 – 5411
Helixi64 – 7310
Helixi75 – 8410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H4BNMR-A2-85[»]
ProteinModelPortaliQ39419.
SMRiQ39419. Positions 2-85.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ39419.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 4236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini42 – 7736EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39419 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADDHPQDKA ERERIFKRFD ANGDGKISAA ELGEALKTLG SITPDEVKHM
60 70 80
MAEIDTDGDG FISFQEFTDF GRANRGLLKD VAKIF
Length:85
Mass (Da):9,448
Last modified:November 1, 1996 - v1
Checksum:iE2FC882E5BB8ADFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711G → A in CAA73147. (PubMed:9345295)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87153 mRNA. Translation: CAA60628.1.
Y12560 mRNA. Translation: CAA73147.1.
PIRiJC5711.
S54819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87153 mRNA. Translation: CAA60628.1 .
Y12560 mRNA. Translation: CAA73147.1 .
PIRi JC5711.
S54819.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1H4B NMR - A 2-85 [» ]
ProteinModelPortali Q39419.
SMRi Q39419. Positions 2-85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-7718600.

Protein family/group databases

Allergomei 129. Bet v 4.
3138. Bet v 4.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q39419.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF00036. EF-hand_1. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains."
    Engel E., Richter K., Obermeyer G., Briza P., Kungl A.J., Simon B., Auer M., Ebner C., Rheinberger H.J., Breitenbach M., Ferreira F.
    J. Biol. Chem. 272:28630-28637(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.
  2. "Molecular characterization, expression in Escherichia coli, and epitope analysis of a two EF-hand calcium-binding birch pollen allergen, Bet v 4."
    Twardosz A., Hayek B., Seiberler S., Pastore A., Vangelista L., Groenlund H., Kraft D., Valenta R.
    Biochem. Biophys. Res. Commun. 239:197-204(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.
  3. "Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function."
    Neudecker P., Nerkamp J., Eisenmann A., Nourse A., Lauber T., Schweimer K., Lehmann K., Schwarzinger S., Ferreira F., Rosch P.
    J. Mol. Biol. 336:1141-1157(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-85, SUBUNIT.

Entry informationi

Entry nameiPOLC4_BETPN
AccessioniPrimary (citable) accession number: Q39419
Secondary accession number(s): O04131
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3