Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q39419 (POLC4_BETPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polcalcin Bet v 4
Alternative name(s):
Calcium-binding pollen allergen Bet v 4
Allergen=Bet v 4
Gene names
Name:BETV4
OrganismBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifier3505 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Monomer. Ref.3

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Contains 2 EF-hand domains.

Ontologies

Keywords
   DiseaseAllergen
   DomainRepeat
   LigandCalcium
Metal-binding
   Technical term3D-structure
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8585Polcalcin Bet v 4
PRO_0000073666

Regions

Domain7 – 4236EF-hand 1
Domain42 – 7736EF-hand 2
Calcium binding20 – 31121
Calcium binding55 – 66122

Experimental info

Sequence conflict711G → A in CAA73147. Ref.2

Secondary structure

.............. 85
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q39419 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E2FC882E5BB8ADFF

FASTA859,448
        10         20         30         40         50         60 
MADDHPQDKA ERERIFKRFD ANGDGKISAA ELGEALKTLG SITPDEVKHM MAEIDTDGDG 

        70         80 
FISFQEFTDF GRANRGLLKD VAKIF 

« Hide

References

[1]"Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains."
Engel E., Richter K., Obermeyer G., Briza P., Kungl A.J., Simon B., Auer M., Ebner C., Rheinberger H.J., Breitenbach M., Ferreira F.
J. Biol. Chem. 272:28630-28637(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.
[2]"Molecular characterization, expression in Escherichia coli, and epitope analysis of a two EF-hand calcium-binding birch pollen allergen, Bet v 4."
Twardosz A., Hayek B., Seiberler S., Pastore A., Vangelista L., Groenlund H., Kraft D., Valenta R.
Biochem. Biophys. Res. Commun. 239:197-204(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.
[3]"Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function."
Neudecker P., Nerkamp J., Eisenmann A., Nourse A., Lauber T., Schweimer K., Lehmann K., Schwarzinger S., Ferreira F., Rosch P.
J. Mol. Biol. 336:1141-1157(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 2-85, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87153 mRNA. Translation: CAA60628.1.
Y12560 mRNA. Translation: CAA73147.1.
PIRJC5711.
S54819.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1H4BNMR-A2-85[»]
ProteinModelPortalQ39419.
SMRQ39419. Positions 2-85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-7718600.

Protein family/group databases

Allergome129. Bet v 4.
3138. Bet v 4.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF00036. EF-hand_1. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ39419.

Entry information

Entry namePOLC4_BETPN
AccessionPrimary (citable) accession number: Q39419
Secondary accession number(s): O04131
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Allergens

Nomenclature of allergens and list of entries