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Q393P5

- GCH42_BURS3

UniProt

Q393P5 - GCH42_BURS3

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Protein
GTP cyclohydrolase FolE2 2
Gene
folE2-2, Bcep18194_B2210
Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBSP269483:GHLS-5630-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 2 (EC:3.5.4.16)
Gene namesi
Name:folE2-2
Ordered Locus Names:Bcep18194_B2210
OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002705: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269GTP cyclohydrolase FolE2 2UniRule annotation
PRO_0000289481Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269483.Bcep18194_B2210.

Structurei

3D structure databases

ProteinModelPortaliQ393P5.
SMRiQ393P5. Positions 21-265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q393P5-1 [UniParc]FASTAAdd to Basket

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MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVCT ESGDVQPTVG    50
VWNLDVRLPA DQKGTHMSRF VALLEENRAP LTVERFRAML ASMLEKLEAE 100
AGRIEVTFPY FVNKTAPVSG VQSLLDYEVT LAGESRNGDT RLFLKVLVPV 150
TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DLPVEALIRI AEEEASCELW 200
GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLDADERVA AYVLEAENFE 250
SIHNHSAYAL IERDKRQAA 269
Length:269
Mass (Da):30,145
Last modified:November 22, 2005 - v1
Checksum:i8FEFF4C7153417FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000152 Genomic DNA. Translation: ABB12321.1.
RefSeqiWP_011355803.1. NC_007511.1.
YP_372965.1. NC_007511.1.

Genome annotation databases

EnsemblBacteriaiABB12321; ABB12321; Bcep18194_B2210.
GeneIDi3753976.
KEGGibur:Bcep18194_B2210.
PATRICi19295321. VBIBurSp120713_7021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000152 Genomic DNA. Translation: ABB12321.1 .
RefSeqi WP_011355803.1. NC_007511.1.
YP_372965.1. NC_007511.1.

3D structure databases

ProteinModelPortali Q393P5.
SMRi Q393P5. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269483.Bcep18194_B2210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB12321 ; ABB12321 ; Bcep18194_B2210 .
GeneIDi 3753976.
KEGGi bur:Bcep18194_B2210.
PATRICi 19295321. VBIBurSp120713_7021.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BSP269483:GHLS-5630-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 383.

Entry informationi

Entry nameiGCH42_BURS3
AccessioniPrimary (citable) accession number: Q393P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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