Reviewed, UniProtKB/Swiss-Prot Q393M6 (KHSE_BURS3)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Bcep18194_B2229

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Homoserine kinase HAMAP MF_00301		PRO_0000300789

Sequences

	Sequence		Length	Mass (Da)
	Q393M6-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 23B3E844F8D52864	FASTA	332	37,266
	10 20 30 40 50 60 MAVFTAVSDS DLAQWMRHYE LGDVLAFRGI PSGIENSNFF LTTTRGEYVL TIFEKLTAEQ 70 80 90 100 110 120 LPFYLDLMSH LAGHGVPVPD PIPRDDGALF GMLHGKPAAI VTKLDGSAEL APGVEHCIEV 130 140 150 160 170 180 GQMLARLHLA GRDYPRNQPN LRSLPWWQEN VPAIVPFITD EQRALLEGEL VHQAGFFASD 190 200 210 220 230 240 DYAALPAGPC HCDLFRDNVL FAHAAPDTGH DVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLATGVLDV ARADALLRAY QTVRPFTAEE RRHWSDMLRA GAYRFWVSRL YDFYLPRAAE 310 320 330 MLKPHDPGHF ERILRERIAH TPALPEIQTA CN

References

[1]

"Complete sequence of chromosome 2 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000152 Genomic DNA. Translation: ABB12340.1.
RefSeq	YP_372984.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q393M6.
Genome annotation databases
GeneID	3753995.
GenomeReviews	Gene locus Bcep18194_B2229 in contig CP000152_GR.
KEGG	bur:Bcep18194_B2229.
NMPDR	fig|269483.3.peg.2265.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q393M6.
OMA	ADLFRDN.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_B2229-MON.
Family and domain databases
HAMAP	MF_00301. [Tree]
InterPro	IPR002575. APH_trans. IPR005280. Homoserine_Kinase_ThrB. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURS3

Accession

Primary (citable) accession number: Q393M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)