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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158UniRule annotation1
Active sitei185UniRule annotation1
Active sitei278UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:Bcep18194_B2303
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254501 – 339Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ393F2.
SMRiQ393F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini141 – 336CheB-type methylesteraseUniRule annotationAdd BLAST196

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000151424.
KOiK13491.
OMAiAMVKIRQ.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q393F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIGIVNDLP LAVEALRRVL ALRTDHRVLW VATDGDEAVD FCVAHPPDLV
60 70 80 90 100
LMDLVMPKVD GVAATRRIMA RAPCAILVVT ASVSANTSSV YEAMGAGALD
110 120 130 140 150
AVDTPTLALG LSTDASPQAL LAKIDQIGRL LESRTAALVP PGPAPERGQP
160 170 180 190 200
TLVAIGASAG GPTALTALLR ALPADFPAAI VIVQHVDQAF ALGMAEWLDG
210 220 230 240 250
YTRLPVRVAR QGSVPQPGEV LLAATNDHLY LSPRGVLGYT RHPVETPYRP
260 270 280 290 300
SIDVFFNSVA DGWQGEAFGV LLTGMGRDGA LGLKAMRAKG CYTIAQDEAT
310 320 330
SAVYGMPKAA AAIGAASAIL PLERIAPQLI SRITRPLRD
Length:339
Mass (Da):35,470
Last modified:November 22, 2005 - v1
Checksum:iC26D892AC034C67C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA. Translation: ABB12414.1.
RefSeqiWP_011355896.1. NC_007511.1.

Genome annotation databases

EnsemblBacteriaiABB12414; ABB12414; Bcep18194_B2303.
KEGGibur:Bcep18194_B2303.
PATRICifig|482957.22.peg.6069.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_BURL3
AccessioniPrimary (citable) accession number: Q393F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome