Q39255 (SKP1A_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SKP1-like protein 1A
Short name=SKP1-like 1

Alternative name(s):
UFO-binding protein 1

Gene names

Name:	SKP1A
Synonyms:	ASK1, SKP1, UIP1
Ordered Locus Names:	At1g75950
ORF Names:	T4O12.17

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation. Ref.8 Ref.9 Ref.10 Ref.11 Ref.23 Ref.26
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Part of a SCF E3 ubiquitin ligase complex composed of SKP1, CUL1, RBX1 (RBX1A or RBX1B) and F-box proteins. Interacts with SKIP1, SKIP2, SKIP3, SKIP4, SKIP6, FIB1/SKIP7, SKIP8, PP2A11/SKIP10, SKIP11, PP2B11/SKIP12, PP2A14/SKIP13, SKIP14, SKIP15, SKIP16, SKIP19/FBL20, SKIP20, PP2B1/SKIP21, SKIP22, SKIP23, SKIP24, SKIP25, TULP10/SKIP26, SKIP27, SKIP28/MEE11, AFR/SKIP29, SKIP30, SKIP31, SKIP32/FBP7, SKIP33, SKIP35, ADO1/ZTL, ADO2/LKP2, ADO3/FKF1, AFR, COI1, DOR, EBF1, EBF2, EID1, ORE9, PP2A13/SKIP9, TIR1, UFO, SKP2A, CPR30, FBL17, At1g55000, At1g67340, At1g78100, At3g04660, At3g61590, At4g38940 and At5g49610. The SKP1A subunit of the SCF E3 ubiquitin ligase complex can interact directly with KIN10, KIN11 and the proteasome subunit PAD1. This interaction can be disrupted by PRL1. In case of polerovirus infection, part of a SCF P0 complex composed of the viral silencing suppressor P0, SKP1 and CUL1. Interacts with turnip yellows virus P0. Interacts with VBF and Agrobacterium virF. Ref.2 Ref.9 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.24 Ref.25 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.37
Subcellular location	Nucleus. Cytoplasm › cytoskeleton › spindle. Cytoplasm › cytoskeleton › phragmoplast. Note: Associated to mitotic spindle and phragmoplasts during cell division. Ref.12
Tissue specificity	Accumulates only in meristematic cells. Expressed in inflorescence, shoot and root apical meristems, as well as in developing organs such as gametocytes and seeds. Also detected in cortical layer and epidermis of roots, leaves, pith and vascular bundle of young stem, young floral buds and organ primordia, pollen and through the valve of siliques. Not detectable in mature root tissues. Ref.2 Ref.7 Ref.23 Ref.26 Ref.27
Developmental stage	During flower development, expressed in the tapetal layer surrounding the male microsporocytes, and in the endothelium layer surrounding the embryo sac within the ovule. During embryogenesis, expressed in all cells of the embryo and in developing endosperm surrounding the embryo, at the time of free nuclei proliferation. Ref.7
Sequence similarities	Belongs to the SKP1 family.
Sequence caution	The sequence AAB38862.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Auxin signaling pathway Chromosome partition Ethylene signaling pathway Host-virus interaction Ubl conjugation pathway
Cellular component	Cytoplasm Cytoskeleton Nucleus
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	auxin mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW ethylene mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW microtubule cytoskeleton organization Inferred from mutant phenotype PubMed 21775187. Source: TAIR multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of DNA recombination Inferred from mutant phenotype PubMed 16283376. Source: TAIR protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway response to cadmium ion Inferred from expression pattern PubMed 16502469. Source: TAIR ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytosol Inferred from direct assay PubMed 21166475. Source: TAIR nucleus Inferred from direct assay Ref.12. Source: TAIR phragmoplast Inferred from direct assay Ref.12. Source: TAIR plasma membrane Inferred from direct assay PubMed 17317660. Source: TAIR spindle Inferred from direct assay Ref.12. Source: TAIR
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q65967	3	EBI-532357,EBI-848577	From a different organism.
ADO1	Q94BT6	9	EBI-532357,EBI-300691
AFR	Q8LAW2	4	EBI-532357,EBI-604438
COI1	O04197	7	EBI-532357,EBI-401159
CUL1	Q94AH6	7	EBI-532357,EBI-532411
EBF1	Q9SKK0	4	EBI-532357,EBI-401198
EID1	Q8LEA8	4	EBI-532357,EBI-687388
GRH1	Q9ZR12	3	EBI-532357,EBI-617479
IAA7	Q38825	2	EBI-532357,EBI-602959
PP2A13	Q9LEX0	4	EBI-532357,EBI-604261
SKIP1	Q9FDX1	5	EBI-532357,EBI-604228
SKIP15	O49279	4	EBI-532357,EBI-591174
SKIP2	Q9FE83	3	EBI-532357,EBI-591107
SKIP28	Q9ZU90	3	EBI-532357,EBI-604427
TIR1	Q570C0	4	EBI-532357,EBI-307183
UFO	Q39090	6	EBI-532357,EBI-590758
virF	P15597	6	EBI-532357,EBI-605118	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 160

160

SKP1-like protein 1A

PRO_0000187255

Regions

Region

102 – 160

59

Interaction with the F-box domain of F-box proteins

Experimental info

Sequence conflict

43

1

P → L in AAB38862. Ref.7

Secondary structure

1

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160

Helix Strand Turn

Details...

Beta strand

6 – 9

4

Beta strand

11 – 13

3

Beta strand

15 – 18

4

Helix

21 – 24

4

Turn

27 – 29

3

Turn

31 – 36

6

Helix

37 – 40

4

Helix

49 – 57

9

Beta strand

89 – 91

3

Helix

102 – 107

6

Helix

111 – 123

13

Turn

124 – 127

4

Helix

130 – 136

7

Helix

145 – 159

15

Sequences

	Sequence		Length	Mass (Da)
	Q39255 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 56B84C19FD5ABF17	FASTA	160	17,857
	10 20 30 40 50 60 MSAKKIVLKS SDGESFEVEE AVALESQTIA HMVEDDCVDN GVPLPNVTSK ILAKVIEYCK 70 80 90 100 110 120 RHVEAAASKA EAVEGAATSD DDLKAWDADF MKIDQATLFE LILAANYLNI KNLLDLTCQT 130 140 150 160 VADMIKGKTP EEIRTTFNIK NDFTPEEEEE VRRENQWAFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression." Connelly C., Hieter P. Cell 86:275-285(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem." Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L. Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH UFO. Strain: cv. Columbia.
[3]	"Overexpression of Arabidopsis thaliana SKP1 homologues in yeast inactivates the Mig1 repressor by destabilising the F-box protein Grr1." Schouten J., de Kam R.J., Fetter K., Hoge J.H.C. Mol. Gen. Genet. 263:309-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Landsberg erecta.
[4]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[5]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[6]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[7]	"Arabidopsis SKP1, a homologue of a cell cycle regulator gene, is predominantly expressed in meristematic cells." Porat R., Lu P., O'Neill S.D. Planta 204:345-351(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-160, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY. Strain: cv. Columbia.
[8]	"The ASK1 gene regulates development and interacts with the UFO gene to control floral organ identity in Arabidopsis." Zhao D., Yang M., Solava J., Ma H. Dev. Genet. 25:209-223(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana." Gray W.M., del Pozo J.C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W.L., Yang M., Ma H., Estelle M. Genes Dev. 13:1678-1691(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TIR1.
[10]	"The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation." Yang M., Hu Y., Lodhi M., McCombie W.R., Ma H. Proc. Natl. Acad. Sci. U.S.A. 96:11416-11421(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis." Zhao D., Yu Q., Chen M., Ma H. Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase." Farras R., Ferrando A., Jasik J., Kleinow T., Oekresz L., Tiburcio A., Salchert K., del Pozo C., Schell J., Koncz C. EMBO J. 20:2742-2756(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SKIP1; SKIP2; SKIP3; SKIP4; SKIP6; FIB1; CUL1; PAD1; KIN10 AND KIN11.
[13]	"EID1, an F-box protein involved in phytochrome A-specific light signaling." Dieterle M., Zhou Y.-C., Schaefer E., Funk M., Kretsch T. Genes Dev. 15:939-944(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EID1.
[14]	"ORE9, an F-box protein that regulates leaf senescence in Arabidopsis." Woo H.R., Chung K.M., Park J.-H., Oh S.A., Ahn T., Hong S.H., Jang S.K., Nam H.G. Plant Cell 13:1779-1790(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ORE9.
[15]	"The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects." Lechner E., Xie D., Grava S., Pigaglio E., Planchais S., Murray J.A.H., Parmentier Y., Mutterer J., Dubreucq B., Shen W.-H., Genschik P. J. Biol. Chem. 277:50069-50080(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A SCF COMPLEX.
[16]	"The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis." Xu L., Liu F., Lechner E., Genschik P., Crosby W.L., Ma H., Peng W., Huang D., Xie D. Plant Cell 14:1919-1935(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH COI1, IDENTIFICATION IN A SCF(COI1) COMPLEX.
[17]	"COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis." Devoto A., Nieto-Rostro M., Xie D., Ellis C., Harmston R., Patrick E., Davis J., Sherratt L., Coleman M., Turner J.G. Plant J. 32:457-466(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH COI1, IDENTIFICATION IN A SCF(COI1) COMPLEX.
[18]	"The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis." Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D. Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UFO; PP2A13; AT1G67340; AT4G38940; SKIP15; AT3G04660; AT1G78100; AT1G55000; SKIP16; SKIP2; SKIP32 AND EBF1.
[19]	"Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor." Guo H., Ecker J.R. Cell 115:667-677(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EBF1 AND EBF2.
[20]	"The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling." Harmon F.G., Kay S.A. Curr. Biol. 13:2091-2096(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AFR.
[21]	"Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis." Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J., Hellmann H., Estelle M., Somers D.E., Crosby W.L. Plant J. 34:753-767(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EID1; SKIP1; SKIP6; SKIP8; PP2A13/SKIP9; PP2A11/SKIP10; SKIP11; PP2B11/SKIP12; PP2A14/SKIP13; SKIP14; SKIP19/FBL20; SKIP20; PP2B1/SKIP21; SKIP22; SKIP23; SKIP24; SKIP25; TULP10/SKIP26; SKIP27; SKIP28/MEE11; AFR/SKIP29; SKIP30; SKIP31; SKIP32/FBP7; SKIP33 AND SKIP35.
[22]	"The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis." Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C. Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UFO.
[23]	"Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis." Zhao D., Ni W., Feng B., Han T., Petrasek M.G., Ma H. Plant Physiol. 133:203-217(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[24]	"Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis." Yasuhara M., Mitsui S., Hirano H., Takanabe R., Tokioka Y., Ihara N., Komatsu A., Seki M., Shinozaki K., Kiyosue T. J. Exp. Bot. 55:2015-2027(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ADO1; ADO2 AND ADO3.
[25]	"Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium." Tzfira T., Vaidya M., Citovsky V. Nature 431:87-92(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AGROBACTERIUM VIRF.
[26]	"The ASK1 and ASK2 genes are essential for Arabidopsis early development." Liu F., Ni W., Griffith M.E., Huang Z., Chang C., Peng W., Ma H., Xie D. Plant Cell 16:5-20(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[27]	"Expression and interaction analysis of Arabidopsis Skp1-related genes." Takahashi N., Kuroda H., Kuromori T., Hirayama T., Seki M., Shinozaki K., Shimada H., Matsui M. Plant Cell Physiol. 45:83-91(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH EBF1/FBL6; COI1/FBL2; ADO3/FKF1; AT3G61590 AND AT5G49610.
[28]	"Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing." Han L., Mason M., Risseeuw E.P., Crosby W.L., Somers D.E. Plant J. 40:291-301(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ADO1.
[29]	"F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function." Pazhouhandeh M., Dieterle M., Marrocco K., Lechner E., Berry B., Brault V., Hemmer O., Kretsch T., Richards K.E., Genschik P., Ziegler-Graff V. Proc. Natl. Acad. Sci. U.S.A. 103:1994-1999(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TURNIP YELLOWS VIRUS PROTEIN P0, IDENTIFICATION IN A SCF P0 COMPLEX.
[30]	"Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors." Kim H.J., Oh S.A., Brownfield L., Hong S.H., Ryu H., Hwang I., Twell D., Nam H.G. Nature 455:1134-1137(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FBL17.
[31]	"SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway." Jurado S., Diaz-Trivino S., Abraham Z., Manzano C., Gutierrez C., del Pozo C. Plant J. 53:828-841(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SKP2A.
[32]	"F-box protein DOR functions as a novel inhibitory factor for abscisic acid-induced stomatal closure under drought stress in Arabidopsis." Zhang Y., Xu W., Li Z., Deng X.W., Wu W., Xue Y. Plant Physiol. 148:2121-2133(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DOR.
[33]	"An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis." Gou M., Su N., Zheng J., Huai J., Wu G., Zhao J., He J., Tang D., Yang S., Wang G. Plant J. 60:757-770(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CPR30.
[34]	"Agrobacterium induces expression of a host F-box protein required for tumorigenicity." Zaltsman A., Krichevsky A., Loyter A., Citovsky V. Cell Host Microbe 7:197-209(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH VBF.
[35]	"Mechanism of auxin perception by the TIR1 ubiquitin ligase." Tan X., Calderon-Villalobos L.I.A., Sharon M., Zheng C., Robinson C.V., Estelle M., Zheng N. Nature 446:640-645(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH TIR1; AUXIN; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN ANALOGS AND MYO-INOSITOL HEXAKISPHOSPHATE.
[36]	"Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling." Hayashi K., Tan X., Zheng N., Hatate T., Kimura Y., Kepinski S., Nozaki H. Proc. Natl. Acad. Sci. U.S.A. 105:5632-5637(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SKP1A; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN; AUXIN AGONISTS; AUXIN ANTAGONISTS AND MYO-INOSITOL HEXAKISPHOSPHATE.
[37]	"Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor." Sheard L.B., Tan X., Mao H., Withers J., Ben-Nissan G., Hinds T.R., Kobayashi Y., Hsu F.F., Sharon M., Browse J., He S.Y., Rizo J., Howe G.A., Zheng N. Nature 468:400-405(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 1-160, INTERACTION WITH COI1.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U60981 mRNA. Translation: AAB17535.1.
U97020 mRNA. Translation: AAC63109.1.
AF059294 mRNA. Translation: AAC14444.1.
AC007396 Genomic DNA. Translation: AAF26761.1.
CP002684 Genomic DNA. Translation: AEE35780.1.
AY080884 mRNA. Translation: AAL87354.1.
AY113971 mRNA. Translation: AAM45019.1.
U70034 mRNA. Translation: AAB38862.1. Different initiation.

IPI

IPI00540205.

PIR

T51309.

RefSeq

NP_565123.1. NM_106245.4.

UniGene

At.23531.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2P1M	X-ray	1.80	A	1-160	[»]
2P1N	X-ray	2.50	A/D	1-160	[»]
2P1O	X-ray	1.90	A	1-160	[»]
2P1P	X-ray	2.21	A	1-160	[»]
2P1Q	X-ray	1.91	A	1-160	[»]
3C6N	X-ray	2.60	A	1-160	[»]
3C6O	X-ray	2.70	A	1-160	[»]
3C6P	X-ray	2.70	A	1-160	[»]
3OGK	X-ray	2.80	A/C/E/G/I/K/M/O	1-160	[»]
3OGL	X-ray	3.18	A/C/E/G/I/K/M/O	1-160	[»]
3OGM	X-ray	3.34	A/C/E/G/I/K/M/O	1-160	[»]

ProteinModelPortal

Q39255.

SMR

Q39255. Positions 5-160.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31325N.

IntAct

Q39255. 67 interactions.

Proteomic databases

PaxDb

Q39255.

PRIDE

Q39255.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblPlants

AT1G75950.1; AT1G75950.1; AT1G75950.

GeneID

843928.

KEGG

ath:AT1G75950.

Organism-specific databases

GeneFarm

4981.

TAIR

At1g75950.

Phylogenomic databases

eggNOG

COG5201.

HOGENOM

HOG000172184.

InParanoid

Q39255.

KO

K03094.

OMA

DDLKAWD.

PhylomeDB

Q39255.

Enzyme and pathway databases

UniPathway

UPA00143.

Gene expression databases

Genevestigator

Q39255.

GermOnline

AT1G75950. Arabidopsis thaliana.

Family and domain databases

Gene3D

3.30.710.10. 1 hit.

InterPro

IPR011333. BTB/POZ_fold.
IPR016897. E3_ubiquit_lig_SCF_Skp.
IPR001232. Skp1_comp.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
[Graphical view]

PANTHER

PTHR11165. PTHR11165. 1 hit.

Pfam

PF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
[Graphical view]

PIRSF

PIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.

SMART

SM00512. Skp1. 1 hit.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.
SSF81382. Skp1_comp_dimer. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q39255.

Entry information

Entry name

SKP1A_ARATH

Accession

Primary (citable) accession number: Q39255
Secondary accession number(s): P92992

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program