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Q39255

- SKP1A_ARATH

UniProt

Q39255 - SKP1A_ARATH

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Protein

SKP1-like protein 1A

Gene

SKP1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.6 Publications

Pathwayi

GO - Biological processi

  1. auxin-activated signaling pathway Source: UniProtKB-KW
  2. chromosome segregation Source: UniProtKB-KW
  3. ethylene-activated signaling pathway Source: UniProtKB-KW
  4. microtubule cytoskeleton organization Source: TAIR
  5. multicellular organismal development Source: UniProtKB-KW
  6. negative regulation of DNA recombination Source: TAIR
  7. protein ubiquitination Source: UniProtKB-UniPathway
  8. response to cadmium ion Source: TAIR
  9. ubiquitin-dependent protein catabolic process Source: InterPro
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Auxin signaling pathway, Chromosome partition, Ethylene signaling pathway, Host-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
SKP1-like protein 1A
Short name:
SKP1-like 1
Alternative name(s):
UFO-binding protein 1
Gene namesi
Name:SKP1A
Synonyms:ASK1, SKP1, UIP1
Ordered Locus Names:At1g75950
ORF Names:T4O12.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G75950.

Subcellular locationi

Nucleus 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication. Cytoplasmcytoskeletonphragmoplast 1 Publication
Note: Associated to mitotic spindle and phragmoplasts during cell division.

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. nucleus Source: TAIR
  3. phragmoplast Source: TAIR
  4. plasma membrane Source: TAIR
  5. spindle Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160SKP1-like protein 1APRO_0000187255Add
BLAST

Proteomic databases

PaxDbiQ39255.
PRIDEiQ39255.

Expressioni

Tissue specificityi

Accumulates only in meristematic cells. Expressed in inflorescence, shoot and root apical meristems, as well as in developing organs such as gametocytes and seeds. Also detected in cortical layer and epidermis of roots, leaves, pith and vascular bundle of young stem, young floral buds and organ primordia, pollen and through the valve of siliques. Not detectable in mature root tissues.5 Publications

Developmental stagei

During flower development, expressed in the tapetal layer surrounding the male microsporocytes, and in the endothelium layer surrounding the embryo sac within the ovule. During embryogenesis, expressed in all cells of the embryo and in developing endosperm surrounding the embryo, at the time of free nuclei proliferation.1 Publication

Gene expression databases

GenevestigatoriQ39255.

Interactioni

Subunit structurei

Part of a SCF E3 ubiquitin ligase complex composed of SKP1, CUL1, RBX1 (RBX1A or RBX1B) and F-box proteins. Interacts with SKIP1, SKIP2, SKIP3, SKIP4, SKIP6, FIB1/SKIP7, SKIP8, PP2A11/SKIP10, SKIP11, PP2B11/SKIP12, PP2A14/SKIP13, SKIP14, SKIP15, SKIP16, SKIP19/FBL20, SKIP20, PP2B1/SKIP21, SKIP22, SKIP23, SKIP24, SKIP25, TULP10/SKIP26, SKIP27, SKIP28/MEE11, AFR/SKIP29, SKIP30, SKIP31, SKIP32/FBP7, SKIP33, SKIP35, ADO1/ZTL, ADO2/LKP2, ADO3/FKF1, AFR, COI1, DOR, EBF1, EBF2, EID1, ORE9, PP2A13/SKIP9, TIR1, UFO, SKP2A, CPR30, FBL17, At1g55000, At1g67340, At1g78100, At3g04660, At3g61590, At4g38940 and At5g49610. The SKP1A subunit of the SCF E3 ubiquitin ligase complex can interact directly with KIN10, KIN11 and the proteasome subunit PAD1. This interaction can be disrupted by PRL1. In case of polerovirus infection, part of a SCF P0 complex composed of the viral silencing suppressor P0, SKP1 and CUL1. Interacts with turnip yellows virus P0. Interacts with VBF and Agrobacterium virF.26 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q659673EBI-532357,EBI-848577From a different organism.
ADO1Q94BT69EBI-532357,EBI-300691
AFRQ8LAW24EBI-532357,EBI-604438
COI1O041977EBI-532357,EBI-401159
CUL1Q94AH67EBI-532357,EBI-532411
EBF1Q9SKK04EBI-532357,EBI-401198
EID1Q8LEA84EBI-532357,EBI-687388
GRH1Q9ZR123EBI-532357,EBI-617479
IAA7Q388252EBI-532357,EBI-602959
PP2A13Q9LEX04EBI-532357,EBI-604261
SKIP1Q9FDX15EBI-532357,EBI-604228
SKIP15O492794EBI-532357,EBI-591174
SKIP2Q9FE833EBI-532357,EBI-591107
SKIP28Q9ZU903EBI-532357,EBI-604427
TIR1Q570C04EBI-532357,EBI-307183
UFOQ390906EBI-532357,EBI-590758
virFP155976EBI-532357,EBI-605118From a different organism.

Protein-protein interaction databases

BioGridi29147. 125 interactions.
DIPiDIP-31325N.
IntActiQ39255. 68 interactions.

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94
Beta strandi11 – 133
Beta strandi15 – 184
Helixi21 – 244
Turni27 – 293
Turni31 – 366
Helixi37 – 404
Helixi49 – 579
Beta strandi89 – 913
Helixi102 – 1076
Helixi111 – 12313
Turni124 – 1274
Helixi130 – 1367
Helixi145 – 15915

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P1MX-ray1.80A1-160[»]
2P1NX-ray2.50A/D1-160[»]
2P1OX-ray1.90A1-160[»]
2P1PX-ray2.21A1-160[»]
2P1QX-ray1.91A1-160[»]
3C6NX-ray2.60A1-160[»]
3C6OX-ray2.70A1-160[»]
3C6PX-ray2.70A1-160[»]
3OGKX-ray2.80A/C/E/G/I/K/M/O1-160[»]
3OGLX-ray3.18A/C/E/G/I/K/M/O1-160[»]
3OGMX-ray3.34A/C/E/G/I/K/M/O1-160[»]
ProteinModelPortaliQ39255.
SMRiQ39255. Positions 5-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ39255.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 16059Interaction with the F-box domain of F-box proteinsAdd
BLAST

Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGiCOG5201.
HOGENOMiHOG000172184.
InParanoidiQ39255.
KOiK03094.
OMAiVIEWATH.
PhylomeDBiQ39255.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR011333. BTB/POZ_fold.
IPR016897. E3_ubiquit_lig_SCF_Skp.
IPR001232. Skp1_comp.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
[Graphical view]
PANTHERiPTHR11165. PTHR11165. 1 hit.
PfamiPF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
[Graphical view]
PIRSFiPIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.
SMARTiSM00512. Skp1. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF81382. SSF81382. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAKKIVLKS SDGESFEVEE AVALESQTIA HMVEDDCVDN GVPLPNVTSK
60 70 80 90 100
ILAKVIEYCK RHVEAAASKA EAVEGAATSD DDLKAWDADF MKIDQATLFE
110 120 130 140 150
LILAANYLNI KNLLDLTCQT VADMIKGKTP EEIRTTFNIK NDFTPEEEEE
160
VRRENQWAFE
Length:160
Mass (Da):17,857
Last modified:November 1, 1996 - v1
Checksum:i56B84C19FD5ABF17
GO

Sequence cautioni

The sequence AAB38862.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431P → L in AAB38862. (PubMed:9530878)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60981 mRNA. Translation: AAB17535.1.
U97020 mRNA. Translation: AAC63109.1.
AF059294 mRNA. Translation: AAC14444.1.
AC007396 Genomic DNA. Translation: AAF26761.1.
CP002684 Genomic DNA. Translation: AEE35780.1.
AY080884 mRNA. Translation: AAL87354.1.
AY113971 mRNA. Translation: AAM45019.1.
U70034 mRNA. Translation: AAB38862.1. Different initiation.
PIRiT51309.
RefSeqiNP_565123.1. NM_106245.4.
UniGeneiAt.23531.

Genome annotation databases

EnsemblPlantsiAT1G75950.1; AT1G75950.1; AT1G75950.
GeneIDi843928.
KEGGiath:AT1G75950.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60981 mRNA. Translation: AAB17535.1 .
U97020 mRNA. Translation: AAC63109.1 .
AF059294 mRNA. Translation: AAC14444.1 .
AC007396 Genomic DNA. Translation: AAF26761.1 .
CP002684 Genomic DNA. Translation: AEE35780.1 .
AY080884 mRNA. Translation: AAL87354.1 .
AY113971 mRNA. Translation: AAM45019.1 .
U70034 mRNA. Translation: AAB38862.1 . Different initiation.
PIRi T51309.
RefSeqi NP_565123.1. NM_106245.4.
UniGenei At.23531.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2P1M X-ray 1.80 A 1-160 [» ]
2P1N X-ray 2.50 A/D 1-160 [» ]
2P1O X-ray 1.90 A 1-160 [» ]
2P1P X-ray 2.21 A 1-160 [» ]
2P1Q X-ray 1.91 A 1-160 [» ]
3C6N X-ray 2.60 A 1-160 [» ]
3C6O X-ray 2.70 A 1-160 [» ]
3C6P X-ray 2.70 A 1-160 [» ]
3OGK X-ray 2.80 A/C/E/G/I/K/M/O 1-160 [» ]
3OGL X-ray 3.18 A/C/E/G/I/K/M/O 1-160 [» ]
3OGM X-ray 3.34 A/C/E/G/I/K/M/O 1-160 [» ]
ProteinModelPortali Q39255.
SMRi Q39255. Positions 5-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 29147. 125 interactions.
DIPi DIP-31325N.
IntActi Q39255. 68 interactions.

Proteomic databases

PaxDbi Q39255.
PRIDEi Q39255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G75950.1 ; AT1G75950.1 ; AT1G75950 .
GeneIDi 843928.
KEGGi ath:AT1G75950.

Organism-specific databases

GeneFarmi 4981.
TAIRi AT1G75950.

Phylogenomic databases

eggNOGi COG5201.
HOGENOMi HOG000172184.
InParanoidi Q39255.
KOi K03094.
OMAi VIEWATH.
PhylomeDBi Q39255.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

EvolutionaryTracei Q39255.
PROi Q39255.

Gene expression databases

Genevestigatori Q39255.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR011333. BTB/POZ_fold.
IPR016897. E3_ubiquit_lig_SCF_Skp.
IPR001232. Skp1_comp.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
[Graphical view ]
PANTHERi PTHR11165. PTHR11165. 1 hit.
Pfami PF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.
SMARTi SM00512. Skp1. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
SSF81382. SSF81382. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression."
    Connelly C., Hieter P.
    Cell 86:275-285(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem."
    Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L.
    Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH UFO.
    Strain: cv. Columbia.
  3. "Overexpression of Arabidopsis thaliana SKP1 homologues in yeast inactivates the Mig1 repressor by destabilising the F-box protein Grr1."
    Schouten J., de Kam R.J., Fetter K., Hoge J.H.C.
    Mol. Gen. Genet. 263:309-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Landsberg erecta.
  4. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  5. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Arabidopsis SKP1, a homologue of a cell cycle regulator gene, is predominantly expressed in meristematic cells."
    Porat R., Lu P., O'Neill S.D.
    Planta 204:345-351(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-160, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  8. "The ASK1 gene regulates development and interacts with the UFO gene to control floral organ identity in Arabidopsis."
    Zhao D., Yang M., Solava J., Ma H.
    Dev. Genet. 25:209-223(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana."
    Gray W.M., del Pozo J.C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W.L., Yang M., Ma H., Estelle M.
    Genes Dev. 13:1678-1691(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TIR1.
  10. "The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation."
    Yang M., Hu Y., Lodhi M., McCombie W.R., Ma H.
    Proc. Natl. Acad. Sci. U.S.A. 96:11416-11421(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis."
    Zhao D., Yu Q., Chen M., Ma H.
    Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase."
    Farras R., Ferrando A., Jasik J., Kleinow T., Oekresz L., Tiburcio A., Salchert K., del Pozo C., Schell J., Koncz C.
    EMBO J. 20:2742-2756(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SKIP1; SKIP2; SKIP3; SKIP4; SKIP6; FIB1; CUL1; PAD1; KIN10 AND KIN11.
  13. "EID1, an F-box protein involved in phytochrome A-specific light signaling."
    Dieterle M., Zhou Y.-C., Schaefer E., Funk M., Kretsch T.
    Genes Dev. 15:939-944(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EID1.
  14. "ORE9, an F-box protein that regulates leaf senescence in Arabidopsis."
    Woo H.R., Chung K.M., Park J.-H., Oh S.A., Ahn T., Hong S.H., Jang S.K., Nam H.G.
    Plant Cell 13:1779-1790(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ORE9.
  15. "The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects."
    Lechner E., Xie D., Grava S., Pigaglio E., Planchais S., Murray J.A.H., Parmentier Y., Mutterer J., Dubreucq B., Shen W.-H., Genschik P.
    J. Biol. Chem. 277:50069-50080(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A SCF COMPLEX.
  16. "The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis."
    Xu L., Liu F., Lechner E., Genschik P., Crosby W.L., Ma H., Peng W., Huang D., Xie D.
    Plant Cell 14:1919-1935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COI1, IDENTIFICATION IN A SCF(COI1) COMPLEX.
  17. "COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis."
    Devoto A., Nieto-Rostro M., Xie D., Ellis C., Harmston R., Patrick E., Davis J., Sherratt L., Coleman M., Turner J.G.
    Plant J. 32:457-466(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COI1, IDENTIFICATION IN A SCF(COI1) COMPLEX.
  18. "The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis."
    Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UFO; PP2A13; AT1G67340; AT4G38940; SKIP15; AT3G04660; AT1G78100; AT1G55000; SKIP16; SKIP2; SKIP32 AND EBF1.
  19. "Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor."
    Guo H., Ecker J.R.
    Cell 115:667-677(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EBF1 AND EBF2.
  20. "The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling."
    Harmon F.G., Kay S.A.
    Curr. Biol. 13:2091-2096(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AFR.
  21. "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis."
    Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J., Hellmann H., Estelle M., Somers D.E., Crosby W.L.
    Plant J. 34:753-767(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EID1; SKIP1; SKIP6; SKIP8; PP2A13/SKIP9; PP2A11/SKIP10; SKIP11; PP2B11/SKIP12; PP2A14/SKIP13; SKIP14; SKIP19/FBL20; SKIP20; PP2B1/SKIP21; SKIP22; SKIP23; SKIP24; SKIP25; TULP10/SKIP26; SKIP27; SKIP28/MEE11; AFR/SKIP29; SKIP30; SKIP31; SKIP32/FBP7; SKIP33 AND SKIP35.
  22. "The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis."
    Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UFO.
  23. "Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis."
    Zhao D., Ni W., Feng B., Han T., Petrasek M.G., Ma H.
    Plant Physiol. 133:203-217(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  24. "Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis."
    Yasuhara M., Mitsui S., Hirano H., Takanabe R., Tokioka Y., Ihara N., Komatsu A., Seki M., Shinozaki K., Kiyosue T.
    J. Exp. Bot. 55:2015-2027(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADO1; ADO2 AND ADO3.
  25. "Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium."
    Tzfira T., Vaidya M., Citovsky V.
    Nature 431:87-92(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AGROBACTERIUM VIRF.
  26. "The ASK1 and ASK2 genes are essential for Arabidopsis early development."
    Liu F., Ni W., Griffith M.E., Huang Z., Chang C., Peng W., Ma H., Xie D.
    Plant Cell 16:5-20(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  27. "Expression and interaction analysis of Arabidopsis Skp1-related genes."
    Takahashi N., Kuroda H., Kuromori T., Hirayama T., Seki M., Shinozaki K., Shimada H., Matsui M.
    Plant Cell Physiol. 45:83-91(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH EBF1/FBL6; COI1/FBL2; ADO3/FKF1; AT3G61590 AND AT5G49610.
  28. "Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing."
    Han L., Mason M., Risseeuw E.P., Crosby W.L., Somers D.E.
    Plant J. 40:291-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADO1.
  29. Cited for: INTERACTION WITH TURNIP YELLOWS VIRUS PROTEIN P0, IDENTIFICATION IN A SCF P0 COMPLEX.
  30. "Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors."
    Kim H.J., Oh S.A., Brownfield L., Hong S.H., Ryu H., Hwang I., Twell D., Nam H.G.
    Nature 455:1134-1137(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FBL17.
  31. "SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway."
    Jurado S., Diaz-Trivino S., Abraham Z., Manzano C., Gutierrez C., del Pozo C.
    Plant J. 53:828-841(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKP2A.
  32. "F-box protein DOR functions as a novel inhibitory factor for abscisic acid-induced stomatal closure under drought stress in Arabidopsis."
    Zhang Y., Xu W., Li Z., Deng X.W., Wu W., Xue Y.
    Plant Physiol. 148:2121-2133(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DOR.
  33. "An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis."
    Gou M., Su N., Zheng J., Huai J., Wu G., Zhao J., He J., Tang D., Yang S., Wang G.
    Plant J. 60:757-770(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CPR30.
  34. "Agrobacterium induces expression of a host F-box protein required for tumorigenicity."
    Zaltsman A., Krichevsky A., Loyter A., Citovsky V.
    Cell Host Microbe 7:197-209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VBF.
  35. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH TIR1; AUXIN; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN ANALOGS AND MYO-INOSITOL HEXAKISPHOSPHATE.
  36. "Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling."
    Hayashi K., Tan X., Zheng N., Hatate T., Kimura Y., Kepinski S., Nozaki H.
    Proc. Natl. Acad. Sci. U.S.A. 105:5632-5637(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SKP1A; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN; AUXIN AGONISTS; AUXIN ANTAGONISTS AND MYO-INOSITOL HEXAKISPHOSPHATE.
  37. Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 1-160, INTERACTION WITH COI1.

Entry informationi

Entry nameiSKP1A_ARATH
AccessioniPrimary (citable) accession number: Q39255
Secondary accession number(s): P92992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3