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Q39255 (SKP1A_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SKP1-like protein 1A

Short name=SKP1-like 1
Alternative name(s):
UFO-binding protein 1
Gene names
Name:SKP1A
Synonyms:ASK1, SKP1, UIP1
Ordered Locus Names:At1g75950
ORF Names:T4O12.17
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation. Ref.8 Ref.9 Ref.10 Ref.11 Ref.23 Ref.26

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of a SCF E3 ubiquitin ligase complex composed of SKP1, CUL1, RBX1 (RBX1A or RBX1B) and F-box proteins. Interacts with SKIP1, SKIP2, SKIP3, SKIP4, SKIP6, FIB1/SKIP7, SKIP8, PP2A11/SKIP10, SKIP11, PP2B11/SKIP12, PP2A14/SKIP13, SKIP14, SKIP15, SKIP16, SKIP19/FBL20, SKIP20, PP2B1/SKIP21, SKIP22, SKIP23, SKIP24, SKIP25, TULP10/SKIP26, SKIP27, SKIP28/MEE11, AFR/SKIP29, SKIP30, SKIP31, SKIP32/FBP7, SKIP33, SKIP35, ADO1/ZTL, ADO2/LKP2, ADO3/FKF1, AFR, COI1, DOR, EBF1, EBF2, EID1, ORE9, PP2A13/SKIP9, TIR1, UFO, SKP2A, CPR30, FBL17, At1g55000, At1g67340, At1g78100, At3g04660, At3g61590, At4g38940 and At5g49610. The SKP1A subunit of the SCF E3 ubiquitin ligase complex can interact directly with KIN10, KIN11 and the proteasome subunit PAD1. This interaction can be disrupted by PRL1. In case of polerovirus infection, part of a SCF P0 complex composed of the viral silencing suppressor P0, SKP1 and CUL1. Interacts with turnip yellows virus P0. Interacts with VBF and Agrobacterium virF. Ref.2 Ref.9 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.24 Ref.25 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.37

Subcellular location

Nucleus. Cytoplasmcytoskeletonspindle. Cytoplasmcytoskeletonphragmoplast. Note: Associated to mitotic spindle and phragmoplasts during cell division. Ref.12

Tissue specificity

Accumulates only in meristematic cells. Expressed in inflorescence, shoot and root apical meristems, as well as in developing organs such as gametocytes and seeds. Also detected in cortical layer and epidermis of roots, leaves, pith and vascular bundle of young stem, young floral buds and organ primordia, pollen and through the valve of siliques. Not detectable in mature root tissues. Ref.2 Ref.7 Ref.23 Ref.26 Ref.27

Developmental stage

During flower development, expressed in the tapetal layer surrounding the male microsporocytes, and in the endothelium layer surrounding the embryo sac within the ovule. During embryogenesis, expressed in all cells of the embryo and in developing endosperm surrounding the embryo, at the time of free nuclei proliferation. Ref.7

Sequence similarities

Belongs to the SKP1 family.

Sequence caution

The sequence AAB38862.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processAuxin signaling pathway
Chromosome partition
Ethylene signaling pathway
Host-virus interaction
Ubl conjugation pathway
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   Molecular functionDevelopmental protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processauxin-activated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

chromosome segregation

Inferred from electronic annotation. Source: UniProtKB-KW

ethylene-activated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule cytoskeleton organization

Inferred from mutant phenotype PubMed 21775187. Source: TAIR

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of DNA recombination

Inferred from mutant phenotype PubMed 16283376. Source: TAIR

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

response to cadmium ion

Inferred from expression pattern PubMed 16502469. Source: TAIR

ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Inferred from direct assay PubMed 21166475. Source: TAIR

nucleus

Inferred from direct assay Ref.12. Source: TAIR

phragmoplast

Inferred from direct assay Ref.12. Source: TAIR

plasma membrane

Inferred from direct assay PubMed 17317660. Source: TAIR

spindle

Inferred from direct assay Ref.12. Source: TAIR

   Molecular_functionprotein binding

Inferred from physical interaction Ref.12Ref.25Ref.35Ref.31Ref.30Ref.33Ref.34. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 160160SKP1-like protein 1A
PRO_0000187255

Regions

Region102 – 16059Interaction with the F-box domain of F-box proteins

Experimental info

Sequence conflict431P → L in AAB38862. Ref.7

Secondary structure

........................... 160
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q39255 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 56B84C19FD5ABF17

FASTA16017,857
        10         20         30         40         50         60 
MSAKKIVLKS SDGESFEVEE AVALESQTIA HMVEDDCVDN GVPLPNVTSK ILAKVIEYCK 

        70         80         90        100        110        120 
RHVEAAASKA EAVEGAATSD DDLKAWDADF MKIDQATLFE LILAANYLNI KNLLDLTCQT 

       130        140        150        160 
VADMIKGKTP EEIRTTFNIK NDFTPEEEEE VRRENQWAFE 

« Hide

References

« Hide 'large scale' references
[1]"Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression."
Connelly C., Hieter P.
Cell 86:275-285(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem."
Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L.
Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH UFO.
Strain: cv. Columbia.
[3]"Overexpression of Arabidopsis thaliana SKP1 homologues in yeast inactivates the Mig1 repressor by destabilising the F-box protein Grr1."
Schouten J., de Kam R.J., Fetter K., Hoge J.H.C.
Mol. Gen. Genet. 263:309-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Landsberg erecta.
[4]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[5]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[6]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[7]"Arabidopsis SKP1, a homologue of a cell cycle regulator gene, is predominantly expressed in meristematic cells."
Porat R., Lu P., O'Neill S.D.
Planta 204:345-351(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-160, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: cv. Columbia.
[8]"The ASK1 gene regulates development and interacts with the UFO gene to control floral organ identity in Arabidopsis."
Zhao D., Yang M., Solava J., Ma H.
Dev. Genet. 25:209-223(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana."
Gray W.M., del Pozo J.C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W.L., Yang M., Ma H., Estelle M.
Genes Dev. 13:1678-1691(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TIR1.
[10]"The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation."
Yang M., Hu Y., Lodhi M., McCombie W.R., Ma H.
Proc. Natl. Acad. Sci. U.S.A. 96:11416-11421(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis."
Zhao D., Yu Q., Chen M., Ma H.
Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase."
Farras R., Ferrando A., Jasik J., Kleinow T., Oekresz L., Tiburcio A., Salchert K., del Pozo C., Schell J., Koncz C.
EMBO J. 20:2742-2756(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SKIP1; SKIP2; SKIP3; SKIP4; SKIP6; FIB1; CUL1; PAD1; KIN10 AND KIN11.
[13]"EID1, an F-box protein involved in phytochrome A-specific light signaling."
Dieterle M., Zhou Y.-C., Schaefer E., Funk M., Kretsch T.
Genes Dev. 15:939-944(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EID1.
[14]"ORE9, an F-box protein that regulates leaf senescence in Arabidopsis."
Woo H.R., Chung K.M., Park J.-H., Oh S.A., Ahn T., Hong S.H., Jang S.K., Nam H.G.
Plant Cell 13:1779-1790(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ORE9.
[15]"The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects."
Lechner E., Xie D., Grava S., Pigaglio E., Planchais S., Murray J.A.H., Parmentier Y., Mutterer J., Dubreucq B., Shen W.-H., Genschik P.
J. Biol. Chem. 277:50069-50080(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A SCF COMPLEX.
[16]"The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis."
Xu L., Liu F., Lechner E., Genschik P., Crosby W.L., Ma H., Peng W., Huang D., Xie D.
Plant Cell 14:1919-1935(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH COI1, IDENTIFICATION IN A SCF(COI1) COMPLEX.
[17]"COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis."
Devoto A., Nieto-Rostro M., Xie D., Ellis C., Harmston R., Patrick E., Davis J., Sherratt L., Coleman M., Turner J.G.
Plant J. 32:457-466(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH COI1, IDENTIFICATION IN A SCF(COI1) COMPLEX.
[18]"The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis."
Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.
Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UFO; PP2A13; AT1G67340; AT4G38940; SKIP15; AT3G04660; AT1G78100; AT1G55000; SKIP16; SKIP2; SKIP32 AND EBF1.
[19]"Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor."
Guo H., Ecker J.R.
Cell 115:667-677(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EBF1 AND EBF2.
[20]"The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling."
Harmon F.G., Kay S.A.
Curr. Biol. 13:2091-2096(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AFR.
[21]"Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis."
Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J., Hellmann H., Estelle M., Somers D.E., Crosby W.L.
Plant J. 34:753-767(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EID1; SKIP1; SKIP6; SKIP8; PP2A13/SKIP9; PP2A11/SKIP10; SKIP11; PP2B11/SKIP12; PP2A14/SKIP13; SKIP14; SKIP19/FBL20; SKIP20; PP2B1/SKIP21; SKIP22; SKIP23; SKIP24; SKIP25; TULP10/SKIP26; SKIP27; SKIP28/MEE11; AFR/SKIP29; SKIP30; SKIP31; SKIP32/FBP7; SKIP33 AND SKIP35.
[22]"The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis."
Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C.
Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UFO.
[23]"Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis."
Zhao D., Ni W., Feng B., Han T., Petrasek M.G., Ma H.
Plant Physiol. 133:203-217(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[24]"Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis."
Yasuhara M., Mitsui S., Hirano H., Takanabe R., Tokioka Y., Ihara N., Komatsu A., Seki M., Shinozaki K., Kiyosue T.
J. Exp. Bot. 55:2015-2027(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ADO1; ADO2 AND ADO3.
[25]"Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium."
Tzfira T., Vaidya M., Citovsky V.
Nature 431:87-92(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AGROBACTERIUM VIRF.
[26]"The ASK1 and ASK2 genes are essential for Arabidopsis early development."
Liu F., Ni W., Griffith M.E., Huang Z., Chang C., Peng W., Ma H., Xie D.
Plant Cell 16:5-20(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[27]"Expression and interaction analysis of Arabidopsis Skp1-related genes."
Takahashi N., Kuroda H., Kuromori T., Hirayama T., Seki M., Shinozaki K., Shimada H., Matsui M.
Plant Cell Physiol. 45:83-91(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH EBF1/FBL6; COI1/FBL2; ADO3/FKF1; AT3G61590 AND AT5G49610.
[28]"Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing."
Han L., Mason M., Risseeuw E.P., Crosby W.L., Somers D.E.
Plant J. 40:291-301(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ADO1.
[29]"F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function."
Pazhouhandeh M., Dieterle M., Marrocco K., Lechner E., Berry B., Brault V., Hemmer O., Kretsch T., Richards K.E., Genschik P., Ziegler-Graff V.
Proc. Natl. Acad. Sci. U.S.A. 103:1994-1999(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TURNIP YELLOWS VIRUS PROTEIN P0, IDENTIFICATION IN A SCF P0 COMPLEX.
[30]"Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors."
Kim H.J., Oh S.A., Brownfield L., Hong S.H., Ryu H., Hwang I., Twell D., Nam H.G.
Nature 455:1134-1137(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FBL17.
[31]"SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway."
Jurado S., Diaz-Trivino S., Abraham Z., Manzano C., Gutierrez C., del Pozo C.
Plant J. 53:828-841(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKP2A.
[32]"F-box protein DOR functions as a novel inhibitory factor for abscisic acid-induced stomatal closure under drought stress in Arabidopsis."
Zhang Y., Xu W., Li Z., Deng X.W., Wu W., Xue Y.
Plant Physiol. 148:2121-2133(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DOR.
[33]"An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis."
Gou M., Su N., Zheng J., Huai J., Wu G., Zhao J., He J., Tang D., Yang S., Wang G.
Plant J. 60:757-770(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CPR30.
[34]"Agrobacterium induces expression of a host F-box protein required for tumorigenicity."
Zaltsman A., Krichevsky A., Loyter A., Citovsky V.
Cell Host Microbe 7:197-209(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH VBF.
[35]"Mechanism of auxin perception by the TIR1 ubiquitin ligase."
Tan X., Calderon-Villalobos L.I.A., Sharon M., Zheng C., Robinson C.V., Estelle M., Zheng N.
Nature 446:640-645(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH TIR1; AUXIN; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN ANALOGS AND MYO-INOSITOL HEXAKISPHOSPHATE.
[36]"Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling."
Hayashi K., Tan X., Zheng N., Hatate T., Kimura Y., Kepinski S., Nozaki H.
Proc. Natl. Acad. Sci. U.S.A. 105:5632-5637(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SKP1A; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN; AUXIN AGONISTS; AUXIN ANTAGONISTS AND MYO-INOSITOL HEXAKISPHOSPHATE.
[37]"Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor."
Sheard L.B., Tan X., Mao H., Withers J., Ben-Nissan G., Hinds T.R., Kobayashi Y., Hsu F.F., Sharon M., Browse J., He S.Y., Rizo J., Howe G.A., Zheng N.
Nature 468:400-405(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 1-160, INTERACTION WITH COI1.
+Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60981 mRNA. Translation: AAB17535.1.
U97020 mRNA. Translation: AAC63109.1.
AF059294 mRNA. Translation: AAC14444.1.
AC007396 Genomic DNA. Translation: AAF26761.1.
CP002684 Genomic DNA. Translation: AEE35780.1.
AY080884 mRNA. Translation: AAL87354.1.
AY113971 mRNA. Translation: AAM45019.1.
U70034 mRNA. Translation: AAB38862.1. Different initiation.
PIRT51309.
RefSeqNP_565123.1. NM_106245.4.
UniGeneAt.23531.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2P1MX-ray1.80A1-160[»]
2P1NX-ray2.50A/D1-160[»]
2P1OX-ray1.90A1-160[»]
2P1PX-ray2.21A1-160[»]
2P1QX-ray1.91A1-160[»]
3C6NX-ray2.60A1-160[»]
3C6OX-ray2.70A1-160[»]
3C6PX-ray2.70A1-160[»]
3OGKX-ray2.80A/C/E/G/I/K/M/O1-160[»]
3OGLX-ray3.18A/C/E/G/I/K/M/O1-160[»]
3OGMX-ray3.34A/C/E/G/I/K/M/O1-160[»]
ProteinModelPortalQ39255.
SMRQ39255. Positions 5-160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid29147. 125 interactions.
DIPDIP-31325N.
IntActQ39255. 67 interactions.

Proteomic databases

PaxDbQ39255.
PRIDEQ39255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G75950.1; AT1G75950.1; AT1G75950.
GeneID843928.
KEGGath:AT1G75950.

Organism-specific databases

GeneFarm4981.
TAIRAT1G75950.

Phylogenomic databases

eggNOGCOG5201.
HOGENOMHOG000172184.
InParanoidQ39255.
KOK03094.
OMAVIEWATH.
PhylomeDBQ39255.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorQ39255.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR011333. BTB/POZ_fold.
IPR016897. E3_ubiquit_lig_SCF_Skp.
IPR001232. Skp1_comp.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
[Graphical view]
PANTHERPTHR11165. PTHR11165. 1 hit.
PfamPF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
[Graphical view]
PIRSFPIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.
SMARTSM00512. Skp1. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
SSF81382. SSF81382. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ39255.
PROQ39255.

Entry information

Entry nameSKP1A_ARATH
AccessionPrimary (citable) accession number: Q39255
Secondary accession number(s): P92992
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names