Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Gene

PP2AB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functioni

  • protein phosphatase type 2A regulator activity Source: TAIR

GO - Biological processi

  • protein dephosphorylation Source: TAIR
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Short name:
AtB beta
Short name:
PP2A, subunit B, beta isoform
Gene namesi
Name:PP2AB2
Ordered Locus Names:At1g17720
ORF Names:F11A6.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17720.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • protein phosphatase type 2A complex Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoformPRO_0000071439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ39247.
PRIDEiQ39247.

PTM databases

iPTMnetiQ39247.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

ExpressionAtlasiQ39247. baseline and differential.
GenevisibleiQ39247. AT.

Interactioni

Subunit structurei

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).By similarity

Protein-protein interaction databases

BioGridi23588. 4 interactions.
IntActiQ39247. 3 interactions.
STRINGi3702.AT1G17720.1.

Structurei

3D structure databases

ProteinModelPortaliQ39247.
SMRiQ39247. Positions 16-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 7340WD 1Add
BLAST
Repeati110 – 15142WD 2Add
BLAST
Repeati220 – 25839WD 3Add
BLAST
Repeati269 – 30941WD 4Add
BLAST
Repeati328 – 36639WD 5Add
BLAST
Repeati471 – 50131WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
HOGENOMiHOG000089745.
InParanoidiQ39247.
KOiK04354.
OMAiHACRKDA.
PhylomeDBiQ39247.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q39247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGDDAATS GPPPSLEWRF SQVFGERTAG EEVQEVDIIS AIEFDKSGDH
60 70 80 90 100
LATGDRGGRV VLFERTDTKD HGGSRKDLEQ TDYPVRHPEF RYKTEFQSHE
110 120 130 140 150
PEFDYLKSLE IEEKINKIRW CQPANGALFL LSTNDKTIKY WKVQEKKIKK
160 170 180 190 200
ISEMNIDPSE SSNIPPQLVT NGLPADKGHD YLSKDFSFPP GGIPSLRLPV
210 220 230 240 250
VVTSQETNLV ARCRRVYAHA HDYHINSISN SSDGETFISA DDLRVNLWNL
260 270 280 290 300
EISNQSFNIV DVKPTNMEDL TEVITSAEFH PIHCNMLAYS SSKGSIRLID
310 320 330 340 350
MRQSALCDSH TKLFEEPEAP GSRSFFTEII ASISDIKFSK DGRYILSRDY
360 370 380 390 400
MTLKLWDINM DSGPVASYQV HEHLRPRLCD LYENDSIFDK FECCLSGDGL
410 420 430 440 450
RVATGSYSNL FRVFGASQGS TEAATLEASK NPMRRQIQTP ARPSRSIGSM
460 470 480 490 500
TRVVRRGSES PGTEANGNAY DFTTKLLHMA WHPTENSIAC AAANSLYMYY

A
Length:501
Mass (Da):56,275
Last modified:November 1, 1996 - v1
Checksum:i030B7997B730F581
GO
Isoform 2 (identifier: Q39247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-200: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):56,176
Checksum:i3D85E84A19E187C0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei200 – 2001Missing in isoform 2. 1 PublicationVSP_017095

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40161 mRNA. Translation: AAB60777.1.
AC034257 Genomic DNA. Translation: AAF99812.1.
CP002684 Genomic DNA. Translation: AEE29626.1.
CP002684 Genomic DNA. Translation: AEE29627.1.
AF370519 mRNA. Translation: AAK43896.1.
AY045665 mRNA. Translation: AAK74023.1.
BT000645 mRNA. Translation: AAN18211.1.
BT002183 mRNA. Translation: AAN72194.1.
PIRiB86312.
RefSeqiNP_564033.1. NM_101634.3. [Q39247-1]
NP_849681.1. NM_179350.3. [Q39247-2]
UniGeneiAt.19970.

Genome annotation databases

EnsemblPlantsiAT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1]
GeneIDi838348.
KEGGiath:AT1G17720.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40161 mRNA. Translation: AAB60777.1.
AC034257 Genomic DNA. Translation: AAF99812.1.
CP002684 Genomic DNA. Translation: AEE29626.1.
CP002684 Genomic DNA. Translation: AEE29627.1.
AF370519 mRNA. Translation: AAK43896.1.
AY045665 mRNA. Translation: AAK74023.1.
BT000645 mRNA. Translation: AAN18211.1.
BT002183 mRNA. Translation: AAN72194.1.
PIRiB86312.
RefSeqiNP_564033.1. NM_101634.3. [Q39247-1]
NP_849681.1. NM_179350.3. [Q39247-2]
UniGeneiAt.19970.

3D structure databases

ProteinModelPortaliQ39247.
SMRiQ39247. Positions 16-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23588. 4 interactions.
IntActiQ39247. 3 interactions.
STRINGi3702.AT1G17720.1.

PTM databases

iPTMnetiQ39247.

Proteomic databases

PaxDbiQ39247.
PRIDEiQ39247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1]
GeneIDi838348.
KEGGiath:AT1G17720.

Organism-specific databases

TAIRiAT1G17720.

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
HOGENOMiHOG000089745.
InParanoidiQ39247.
KOiK04354.
OMAiHACRKDA.
PhylomeDBiQ39247.

Enzyme and pathway databases

ReactomeiR-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ39247.

Gene expression databases

ExpressionAtlasiQ39247. baseline and differential.
GenevisibleiQ39247. AT.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of DNA sequences encoding a novel isoform of the 55 kDa B regulatory subunit of the type 2A protein serine/threonine phosphatase of Arabidopsis thaliana."
    Corum J.W. III, Hartung A.J., Stamey R.T., Rundle S.J.
    Plant Mol. Biol. 31:419-427(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: cv. Columbia.
  5. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei2ABB_ARATH
AccessioniPrimary (citable) accession number: Q39247
Secondary accession number(s): Q9FZ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.