PP2AB2

Functionⁱ

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functionⁱ

protein phosphatase regulator activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

developmental process Source: GO_Central
mitotic cell cycle Source: GO_Central
peptidyl-serine dephosphorylation Source: GO_Central
protein dephosphorylation
Source: TAIR
Inferred from sequence or structural similarityⁱ
- 8756607

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-ATH-69231. Cyclin D associated events in G1. R-ATH-69273. Cyclin A/B1/B2 associated events during G2/M transition. R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Reactomeⁱ

R-ATH-69231. Cyclin D associated events in G1.
R-ATH-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Short name: AtB beta Short name: PP2A, subunit B, beta isoform
Gene namesⁱ	Name:PP2AB2 Ordered Locus Names:At1g17720 ORF Names:F11A6.6
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT1G17720.
TAIRⁱ	locus:2007963. AT1G17720.

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071439	1 – 501	Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST		501

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	Q39247.

PaxDbⁱ

Q39247.

PTM databases

iPTMnetⁱ	Q39247.

iPTMnetⁱ

Q39247.

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously.1 Publication

Gene expression databases

ExpressionAtlasⁱ	Q39247. baseline and differential.
Genevisibleⁱ	Q39247. AT.

Interactionⁱ

Subunit structureⁱ

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families) (By similarity). Interacts with SIC/RON3 (PubMed:26888284).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	23588. 7 interactors.
IntActⁱ	Q39247. 3 interactors.
STRINGⁱ	3702.AT1G17720.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q39247.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	34 – 73	WD 1Add BLAST	40
Repeatⁱ	110 – 151	WD 2Add BLAST	42
Repeatⁱ	220 – 258	WD 3Add BLAST	39
Repeatⁱ	269 – 309	WD 4Add BLAST	41
Repeatⁱ	328 – 366	WD 5Add BLAST	39
Repeatⁱ	471 – 501	WD 6Add BLAST	31

Sequence similaritiesⁱ

Belongs to the phosphatase 2A regulatory subunit B family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG1354. Eukaryota. COG5170. LUCA.
HOGENOMⁱ	HOG000089745.
InParanoidⁱ	Q39247.
KEGG Orthology (KO) More...KOⁱ	K04354.
OMAⁱ	LMVEVRP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608G6.
PhylomeDBⁱ	Q39247.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR036322. WD40_repeat_dom_sf.
PANTHERⁱ	PTHR11871. PTHR11871. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400. WD40. 2 hits.
PIRSFⁱ	PIRSF037309. PP2A_PR55. 1 hit.
PRINTSⁱ	PR00600. PP2APR55.
SMARTⁱ	View protein in SMART SM00320. WD40. 5 hits.
SUPFAMⁱ	SSF50978. SSF50978. 3 hits.
PROSITEⁱ	View protein in PROSITE PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q39247-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGDDAATS GPPPSLEWRF SQVFGERTAG EEVQEVDIIS AIEFDKSGDH 
        60         70         80         90        100
LATGDRGGRV VLFERTDTKD HGGSRKDLEQ TDYPVRHPEF RYKTEFQSHE 
       110        120        130        140        150
PEFDYLKSLE IEEKINKIRW CQPANGALFL LSTNDKTIKY WKVQEKKIKK 
       160        170        180        190        200
ISEMNIDPSE SSNIPPQLVT NGLPADKGHD YLSKDFSFPP GGIPSLRLPV 
       210        220        230        240        250
VVTSQETNLV ARCRRVYAHA HDYHINSISN SSDGETFISA DDLRVNLWNL 
       260        270        280        290        300
EISNQSFNIV DVKPTNMEDL TEVITSAEFH PIHCNMLAYS SSKGSIRLID 
       310        320        330        340        350
MRQSALCDSH TKLFEEPEAP GSRSFFTEII ASISDIKFSK DGRYILSRDY 
       360        370        380        390        400
MTLKLWDINM DSGPVASYQV HEHLRPRLCD LYENDSIFDK FECCLSGDGL 
       410        420        430        440        450
RVATGSYSNL FRVFGASQGS TEAATLEASK NPMRRQIQTP ARPSRSIGSM 
       460        470        480        490        500
TRVVRRGSES PGTEANGNAY DFTTKLLHMA WHPTENSIAC AAANSLYMYY 

A

Length:501

Mass (Da):56,275

Last modified:November 1, 1996 - v1

Checksum:ⁱ030B7997B730F581

GO

Isoform 2 (identifier: Q39247-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
200-200: Missing.

« Hide

        10         20         30         40         50
MNGGDDAATS GPPPSLEWRF SQVFGERTAG EEVQEVDIIS AIEFDKSGDH 
        60         70         80         90        100
LATGDRGGRV VLFERTDTKD HGGSRKDLEQ TDYPVRHPEF RYKTEFQSHE 
       110        120        130        140        150
PEFDYLKSLE IEEKINKIRW CQPANGALFL LSTNDKTIKY WKVQEKKIKK 
       160        170        180        190        200
ISEMNIDPSE SSNIPPQLVT NGLPADKGHD YLSKDFSFPP GGIPSLRLPV 
       210        220        230        240        250
VTSQETNLVA RCRRVYAHAH DYHINSISNS SDGETFISAD DLRVNLWNLE 
       260        270        280        290        300
ISNQSFNIVD VKPTNMEDLT EVITSAEFHP IHCNMLAYSS SKGSIRLIDM 
       310        320        330        340        350
RQSALCDSHT KLFEEPEAPG SRSFFTEIIA SISDIKFSKD GRYILSRDYM 
       360        370        380        390        400
TLKLWDINMD SGPVASYQVH EHLRPRLCDL YENDSIFDKF ECCLSGDGLR 
       410        420        430        440        450
VATGSYSNLF RVFGASQGST EAATLEASKN PMRRQIQTPA RPSRSIGSMT 
       460        470        480        490        500
RVVRRGSESP GTEANGNAYD FTTKLLHMAW HPTENSIACA AANSLYMYYA

Note: No experimental confirmation available.

Show »

Length:500

Mass (Da):56,176

Checksum:ⁱ3D85E84A19E187C0

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017095	200	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40161 mRNA. Translation: AAB60777.1. AC034257 Genomic DNA. Translation: AAF99812.1. CP002684 Genomic DNA. Translation: AEE29626.1. CP002684 Genomic DNA. Translation: AEE29627.1. AF370519 mRNA. Translation: AAK43896.1. AY045665 mRNA. Translation: AAK74023.1. BT000645 mRNA. Translation: AAN18211.1. BT002183 mRNA. Translation: AAN72194.1.
PIRⁱ	B86312.
NCBI Reference Sequences More...RefSeqⁱ	NP_564033.1. NM_101634.4. [Q39247-1] NP_849681.1. NM_179350.4. [Q39247-2]
UniGeneⁱ	At.19970.

Genome annotation databases

EnsemblPlantsⁱ	AT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1] AT1G17720.2; AT1G17720.2; AT1G17720. [Q39247-2]
GeneIDⁱ	838348.
Grameneⁱ	AT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1] AT1G17720.2; AT1G17720.2; AT1G17720. [Q39247-2]
KEGGⁱ	ath:AT1G17720.

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q39247	Q0WW19	Arabidopsis thaliana (Mouse-ear cress)	501	UniRef100_Q39247	Cluster: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q39247	Q0WW19 UPI0006AA6AD1 UPI0004F198DE A0A1J3JR46 UPI0006A6DB34 A0A087HPA4 UPI00085A1B63 UPI00085AAD6F A0A087HPA5 A0A1J3IAL9 +42	Arabidopsis thaliana (Mouse-ear cress) Brassica napus (Rape) Brassica campestris (Field mustard) Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens) Brassica oleracea var. oleracea Arabis alpina (Alpine rock-cress) Raphanus sativus (Radish) Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum) Camelina sativa (False flax) (Myagrum sativum) Capsella rubella And more	501	UniRef90_Q39247	Cluster: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	53

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q39247	Q0WW19 UPI0004F198DE UPI0006AA6AD1 UPI0006A6DB34 A0A1J3JR46 A0A087HPA4 UPI0006AABDA4 UPI00085A1B63 A0A1J3IAL9 A0A1J3DE70 +515	Arabidopsis thaliana (Mouse-ear cress) Brassica campestris (Field mustard) Brassica napus (Rape) Brassica oleracea var. oleracea Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens) Arabis alpina (Alpine rock-cress) Raphanus sativus (Radish) Camelina sativa (False flax) (Myagrum sativum) Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum) Capsella rubella And more	501	UniRef50_Q39247	Cluster: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	526

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40161 mRNA. Translation: AAB60777.1. AC034257 Genomic DNA. Translation: AAF99812.1. CP002684 Genomic DNA. Translation: AEE29626.1. CP002684 Genomic DNA. Translation: AEE29627.1. AF370519 mRNA. Translation: AAK43896.1. AY045665 mRNA. Translation: AAK74023.1. BT000645 mRNA. Translation: AAN18211.1. BT002183 mRNA. Translation: AAN72194.1.
PIRⁱ	B86312.
NCBI Reference Sequences More...RefSeqⁱ	NP_564033.1. NM_101634.4. [Q39247-1] NP_849681.1. NM_179350.4. [Q39247-2]
UniGeneⁱ	At.19970.

3D structure databases

ProteinModelPortalⁱ	Q39247.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	23588. 7 interactors.
IntActⁱ	Q39247. 3 interactors.
STRINGⁱ	3702.AT1G17720.1.

PTM databases

iPTMnetⁱ	Q39247.

iPTMnetⁱ

Q39247.

Proteomic databases

PaxDbⁱ	Q39247.

PaxDbⁱ

Q39247.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1] AT1G17720.2; AT1G17720.2; AT1G17720. [Q39247-2]
GeneIDⁱ	838348.
Grameneⁱ	AT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1] AT1G17720.2; AT1G17720.2; AT1G17720. [Q39247-2]
KEGGⁱ	ath:AT1G17720.

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT1G17720.
TAIRⁱ	locus:2007963. AT1G17720.

Phylogenomic databases

eggNOGⁱ	KOG1354. Eukaryota. COG5170. LUCA.
HOGENOMⁱ	HOG000089745.
InParanoidⁱ	Q39247.
KEGG Orthology (KO) More...KOⁱ	K04354.
OMAⁱ	LMVEVRP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608G6.
PhylomeDBⁱ	Q39247.

Enzyme and pathway databases

Reactomeⁱ	R-ATH-69231. Cyclin D associated events in G1. R-ATH-69273. Cyclin A/B1/B2 associated events during G2/M transition. R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Reactomeⁱ

R-ATH-69231. Cyclin D associated events in G1.
R-ATH-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q39247.

PROⁱ

PR:Q39247.

Gene expression databases

ExpressionAtlasⁱ	Q39247. baseline and differential.
Genevisibleⁱ	Q39247. AT.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR036322. WD40_repeat_dom_sf.
PANTHERⁱ	PTHR11871. PTHR11871. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400. WD40. 2 hits.
PIRSFⁱ	PIRSF037309. PP2A_PR55. 1 hit.
PRINTSⁱ	PR00600. PP2APR55.
SMARTⁱ	View protein in SMART SM00320. WD40. 5 hits.
SUPFAMⁱ	SSF50978. SSF50978. 3 hits.
PROSITEⁱ	View protein in PROSITE PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	2ABB_ARATH
Accessionⁱ	Q39247Primary (citable) accession number: Q39247 Secondary accession number(s): Q9FZ61
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	November 1, 1996
	Last modified:	February 28, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q39247 (2ABB_ARATH)

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Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ