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Protein

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Gene

PP2AB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functioni

  • protein phosphatase type 2A regulator activity Source: TAIR

GO - Biological processi

  • developmental process Source: GO_Central
  • mitotic cell cycle Source: GO_Central
  • peptidyl-serine dephosphorylation Source: GO_Central
  • protein dephosphorylation Source: TAIR
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Short name:
AtB beta
Short name:
PP2A, subunit B, beta isoform
Gene namesi
Name:PP2AB2
Ordered Locus Names:At1g17720
ORF Names:F11A6.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17720.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • protein phosphatase type 2A complex Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714391 – 501Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ39247.

PTM databases

iPTMnetiQ39247.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

ExpressionAtlasiQ39247. baseline and differential.
GenevisibleiQ39247. AT.

Interactioni

Subunit structurei

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).By similarity

Protein-protein interaction databases

BioGridi23588. 4 interactors.
IntActiQ39247. 3 interactors.
STRINGi3702.AT1G17720.1.

Structurei

3D structure databases

ProteinModelPortaliQ39247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 73WD 1Add BLAST40
Repeati110 – 151WD 2Add BLAST42
Repeati220 – 258WD 3Add BLAST39
Repeati269 – 309WD 4Add BLAST41
Repeati328 – 366WD 5Add BLAST39
Repeati471 – 501WD 6Add BLAST31

Sequence similaritiesi

Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
HOGENOMiHOG000089745.
InParanoidiQ39247.
KOiK04354.
OMAiRVSEMNL.
OrthoDBiEOG093608G6.
PhylomeDBiQ39247.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q39247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGDDAATS GPPPSLEWRF SQVFGERTAG EEVQEVDIIS AIEFDKSGDH
60 70 80 90 100
LATGDRGGRV VLFERTDTKD HGGSRKDLEQ TDYPVRHPEF RYKTEFQSHE
110 120 130 140 150
PEFDYLKSLE IEEKINKIRW CQPANGALFL LSTNDKTIKY WKVQEKKIKK
160 170 180 190 200
ISEMNIDPSE SSNIPPQLVT NGLPADKGHD YLSKDFSFPP GGIPSLRLPV
210 220 230 240 250
VVTSQETNLV ARCRRVYAHA HDYHINSISN SSDGETFISA DDLRVNLWNL
260 270 280 290 300
EISNQSFNIV DVKPTNMEDL TEVITSAEFH PIHCNMLAYS SSKGSIRLID
310 320 330 340 350
MRQSALCDSH TKLFEEPEAP GSRSFFTEII ASISDIKFSK DGRYILSRDY
360 370 380 390 400
MTLKLWDINM DSGPVASYQV HEHLRPRLCD LYENDSIFDK FECCLSGDGL
410 420 430 440 450
RVATGSYSNL FRVFGASQGS TEAATLEASK NPMRRQIQTP ARPSRSIGSM
460 470 480 490 500
TRVVRRGSES PGTEANGNAY DFTTKLLHMA WHPTENSIAC AAANSLYMYY

A
Length:501
Mass (Da):56,275
Last modified:November 1, 1996 - v1
Checksum:i030B7997B730F581
GO
Isoform 2 (identifier: Q39247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-200: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):56,176
Checksum:i3D85E84A19E187C0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017095200Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40161 mRNA. Translation: AAB60777.1.
AC034257 Genomic DNA. Translation: AAF99812.1.
CP002684 Genomic DNA. Translation: AEE29626.1.
CP002684 Genomic DNA. Translation: AEE29627.1.
AF370519 mRNA. Translation: AAK43896.1.
AY045665 mRNA. Translation: AAK74023.1.
BT000645 mRNA. Translation: AAN18211.1.
BT002183 mRNA. Translation: AAN72194.1.
PIRiB86312.
RefSeqiNP_564033.1. NM_101634.4. [Q39247-1]
NP_849681.1. NM_179350.4. [Q39247-2]
UniGeneiAt.19970.

Genome annotation databases

EnsemblPlantsiAT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1]
GeneIDi838348.
GrameneiAT1G17720.1; AT1G17720.1; AT1G17720.
KEGGiath:AT1G17720.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40161 mRNA. Translation: AAB60777.1.
AC034257 Genomic DNA. Translation: AAF99812.1.
CP002684 Genomic DNA. Translation: AEE29626.1.
CP002684 Genomic DNA. Translation: AEE29627.1.
AF370519 mRNA. Translation: AAK43896.1.
AY045665 mRNA. Translation: AAK74023.1.
BT000645 mRNA. Translation: AAN18211.1.
BT002183 mRNA. Translation: AAN72194.1.
PIRiB86312.
RefSeqiNP_564033.1. NM_101634.4. [Q39247-1]
NP_849681.1. NM_179350.4. [Q39247-2]
UniGeneiAt.19970.

3D structure databases

ProteinModelPortaliQ39247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23588. 4 interactors.
IntActiQ39247. 3 interactors.
STRINGi3702.AT1G17720.1.

PTM databases

iPTMnetiQ39247.

Proteomic databases

PaxDbiQ39247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1]
GeneIDi838348.
GrameneiAT1G17720.1; AT1G17720.1; AT1G17720.
KEGGiath:AT1G17720.

Organism-specific databases

TAIRiAT1G17720.

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
HOGENOMiHOG000089745.
InParanoidiQ39247.
KOiK04354.
OMAiRVSEMNL.
OrthoDBiEOG093608G6.
PhylomeDBiQ39247.

Enzyme and pathway databases

ReactomeiR-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ39247.

Gene expression databases

ExpressionAtlasiQ39247. baseline and differential.
GenevisibleiQ39247. AT.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2ABB_ARATH
AccessioniPrimary (citable) accession number: Q39247
Secondary accession number(s): Q9FZ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.