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Protein

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Gene

PP2AB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functioni

GO - Biological processi

  • developmental process Source: GO_Central
  • mitotic cell cycle Source: GO_Central
  • peptidyl-serine dephosphorylation Source: GO_Central
  • protein dephosphorylation Source: TAIR

Enzyme and pathway databases

ReactomeiR-ATH-69231 Cyclin D associated events in G1
R-ATH-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-ATH-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Short name:
AtB beta
Short name:
PP2A, subunit B, beta isoform
Gene namesi
Name:PP2AB2
Ordered Locus Names:At1g17720
ORF Names:F11A6.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G17720
TAIRilocus:2007963 AT1G17720

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714391 – 501Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ39247
PRIDEiQ39247

PTM databases

iPTMnetiQ39247

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

ExpressionAtlasiQ39247 baseline and differential
GenevisibleiQ39247 AT

Interactioni

Subunit structurei

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families) (By similarity). Interacts with SIC/RON3 (PubMed:26888284).By similarity1 Publication

Protein-protein interaction databases

BioGridi23588, 7 interactors
IntActiQ39247, 3 interactors
STRINGi3702.AT1G17720.1

Structurei

3D structure databases

ProteinModelPortaliQ39247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 73WD 1Add BLAST40
Repeati110 – 151WD 2Add BLAST42
Repeati220 – 258WD 3Add BLAST39
Repeati269 – 309WD 4Add BLAST41
Repeati328 – 366WD 5Add BLAST39
Repeati471 – 501WD 6Add BLAST31

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
HOGENOMiHOG000089745
InParanoidiQ39247
KOiK04354
OMAiLMVEVRP
OrthoDBiEOG093608G6
PhylomeDBiQ39247

Family and domain databases

InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q39247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGDDAATS GPPPSLEWRF SQVFGERTAG EEVQEVDIIS AIEFDKSGDH
60 70 80 90 100
LATGDRGGRV VLFERTDTKD HGGSRKDLEQ TDYPVRHPEF RYKTEFQSHE
110 120 130 140 150
PEFDYLKSLE IEEKINKIRW CQPANGALFL LSTNDKTIKY WKVQEKKIKK
160 170 180 190 200
ISEMNIDPSE SSNIPPQLVT NGLPADKGHD YLSKDFSFPP GGIPSLRLPV
210 220 230 240 250
VVTSQETNLV ARCRRVYAHA HDYHINSISN SSDGETFISA DDLRVNLWNL
260 270 280 290 300
EISNQSFNIV DVKPTNMEDL TEVITSAEFH PIHCNMLAYS SSKGSIRLID
310 320 330 340 350
MRQSALCDSH TKLFEEPEAP GSRSFFTEII ASISDIKFSK DGRYILSRDY
360 370 380 390 400
MTLKLWDINM DSGPVASYQV HEHLRPRLCD LYENDSIFDK FECCLSGDGL
410 420 430 440 450
RVATGSYSNL FRVFGASQGS TEAATLEASK NPMRRQIQTP ARPSRSIGSM
460 470 480 490 500
TRVVRRGSES PGTEANGNAY DFTTKLLHMA WHPTENSIAC AAANSLYMYY

A
Length:501
Mass (Da):56,275
Last modified:November 1, 1996 - v1
Checksum:i030B7997B730F581
GO
Isoform 2 (identifier: Q39247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-200: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):56,176
Checksum:i3D85E84A19E187C0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017095200Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40161 mRNA Translation: AAB60777.1
AC034257 Genomic DNA Translation: AAF99812.1
CP002684 Genomic DNA Translation: AEE29626.1
CP002684 Genomic DNA Translation: AEE29627.1
AF370519 mRNA Translation: AAK43896.1
AY045665 mRNA Translation: AAK74023.1
BT000645 mRNA Translation: AAN18211.1
BT002183 mRNA Translation: AAN72194.1
PIRiB86312
RefSeqiNP_564033.1, NM_101634.4 [Q39247-1]
NP_849681.1, NM_179350.4 [Q39247-2]
UniGeneiAt.19970

Genome annotation databases

EnsemblPlantsiAT1G17720.1; AT1G17720.1; AT1G17720 [Q39247-1]
AT1G17720.2; AT1G17720.2; AT1G17720 [Q39247-2]
GeneIDi838348
GrameneiAT1G17720.1; AT1G17720.1; AT1G17720 [Q39247-1]
AT1G17720.2; AT1G17720.2; AT1G17720 [Q39247-2]
KEGGiath:AT1G17720

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei2ABB_ARATH
AccessioniPrimary (citable) accession number: Q39247
Secondary accession number(s): Q9FZ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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