UniProtKB - Q39247 (2ABB_ARATH)
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Protein
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Gene
PP2AB2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity
GO - Molecular functioni
- protein phosphatase regulator activity Source: GO_Central
GO - Biological processi
- developmental process Source: GO_Central
- mitotic cell cycle Source: GO_Central
- peptidyl-serine dephosphorylation Source: GO_Central
- protein dephosphorylation Source: TAIR
Enzyme and pathway databases
Reactomei | R-ATH-69231. Cyclin D associated events in G1. R-ATH-69273. Cyclin A/B1/B2 associated events during G2/M transition. R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoformShort name: AtB beta Short name: PP2A, subunit B, beta isoform |
Gene namesi | Name:PP2AB2 Ordered Locus Names:At1g17720 ORF Names:F11A6.6 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G17720. |
TAIRi | locus:2007963. AT1G17720. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071439 | 1 – 501 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q39247. |
PTM databases
iPTMneti | Q39247. |
Expressioni
Tissue specificityi
Expressed ubiquitously.1 Publication
Gene expression databases
ExpressionAtlasi | Q39247. baseline and differential. |
Genevisiblei | Q39247. AT. |
Interactioni
Subunit structurei
PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families) (By similarity). Interacts with SIC/RON3 (PubMed:26888284).By similarity1 Publication
Protein-protein interaction databases
BioGridi | 23588. 7 interactors. |
IntActi | Q39247. 3 interactors. |
STRINGi | 3702.AT1G17720.1. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 34 – 73 | WD 1Add BLAST | 40 | |
Repeati | 110 – 151 | WD 2Add BLAST | 42 | |
Repeati | 220 – 258 | WD 3Add BLAST | 39 | |
Repeati | 269 – 309 | WD 4Add BLAST | 41 | |
Repeati | 328 – 366 | WD 5Add BLAST | 39 | |
Repeati | 471 – 501 | WD 6Add BLAST | 31 |
Sequence similaritiesi
Belongs to the phosphatase 2A regulatory subunit B family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354. Eukaryota. COG5170. LUCA. |
HOGENOMi | HOG000089745. |
InParanoidi | Q39247. |
KOi | K04354. |
OMAi | LMVEVRP. |
OrthoDBi | EOG093608G6. |
PhylomeDBi | Q39247. |
Family and domain databases
InterProi | View protein in InterPro IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR036322. WD40_repeat_dom_sf. |
PANTHERi | PTHR11871. PTHR11871. 1 hit. |
Pfami | View protein in Pfam PF00400. WD40. 2 hits. |
PIRSFi | PIRSF037309. PP2A_PR55. 1 hit. |
PRINTSi | PR00600. PP2APR55. |
SMARTi | View protein in SMART SM00320. WD40. 5 hits. |
SUPFAMi | SSF50978. SSF50978. 3 hits. |
PROSITEi | View protein in PROSITE PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q39247-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNGGDDAATS GPPPSLEWRF SQVFGERTAG EEVQEVDIIS AIEFDKSGDH
60 70 80 90 100
LATGDRGGRV VLFERTDTKD HGGSRKDLEQ TDYPVRHPEF RYKTEFQSHE
110 120 130 140 150
PEFDYLKSLE IEEKINKIRW CQPANGALFL LSTNDKTIKY WKVQEKKIKK
160 170 180 190 200
ISEMNIDPSE SSNIPPQLVT NGLPADKGHD YLSKDFSFPP GGIPSLRLPV
210 220 230 240 250
VVTSQETNLV ARCRRVYAHA HDYHINSISN SSDGETFISA DDLRVNLWNL
260 270 280 290 300
EISNQSFNIV DVKPTNMEDL TEVITSAEFH PIHCNMLAYS SSKGSIRLID
310 320 330 340 350
MRQSALCDSH TKLFEEPEAP GSRSFFTEII ASISDIKFSK DGRYILSRDY
360 370 380 390 400
MTLKLWDINM DSGPVASYQV HEHLRPRLCD LYENDSIFDK FECCLSGDGL
410 420 430 440 450
RVATGSYSNL FRVFGASQGS TEAATLEASK NPMRRQIQTP ARPSRSIGSM
460 470 480 490 500
TRVVRRGSES PGTEANGNAY DFTTKLLHMA WHPTENSIAC AAANSLYMYY
A
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017095 | 200 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40161 mRNA. Translation: AAB60777.1. AC034257 Genomic DNA. Translation: AAF99812.1. CP002684 Genomic DNA. Translation: AEE29626.1. CP002684 Genomic DNA. Translation: AEE29627.1. AF370519 mRNA. Translation: AAK43896.1. AY045665 mRNA. Translation: AAK74023.1. BT000645 mRNA. Translation: AAN18211.1. BT002183 mRNA. Translation: AAN72194.1. |
PIRi | B86312. |
RefSeqi | NP_564033.1. NM_101634.4. [Q39247-1] NP_849681.1. NM_179350.4. [Q39247-2] |
UniGenei | At.19970. |
Genome annotation databases
EnsemblPlantsi | AT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1] AT1G17720.2; AT1G17720.2; AT1G17720. [Q39247-2] |
GeneIDi | 838348. |
Gramenei | AT1G17720.1; AT1G17720.1; AT1G17720. [Q39247-1] AT1G17720.2; AT1G17720.2; AT1G17720. [Q39247-2] |
KEGGi | ath:AT1G17720. |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | 2ABB_ARATH | |
Accessioni | Q39247Primary (citable) accession number: Q39247 Secondary accession number(s): Q9FZ61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 28, 2018 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |