Thioredoxin reductase 2 - Arabidopsis thaliana (Mouse-ear cress)

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Reviewed, UniProtKB/Swiss-Prot Q39242 (TRXB2_ARATH)

Last modified October 13, 2009. Version 84. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Thioredoxin reductase 2
    EC=1.8.1.9
Alternative name(s):
    NADPH-dependent thioredoxin reductase 2
      Short name=NTR 2

Gene names

Name:	NTR2
Ordered Locus Names:	At2g17420
ORF Names:	F5J6.18

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Catalytic activity	Thioredoxin + NADP⁺ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Miscellaneous	The active site is a redox-active disulfide bond By similarity.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

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Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell growth Inferred from genetic interaction. Source: TAIR cell redox homeostasis Inferred from genetic interaction. Source: TAIR oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pollen germination Inferred from genetic interaction. Source: TAIR removal of superoxide radicals Inferred from electronic annotation. Source: InterPro response to cadmium ion Inferred from expression pattern. Source: TAIR seed development Inferred from genetic interaction. Source: TAIR thioredoxin biosynthetic process Inferred from genetic interaction. Source: TAIR
Cellular component	cytosol Inferred from direct assay. Source: TAIR mitochondrial matrix Inferred from direct assay. Source: TAIR
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from direct assay. Source: TAIR
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 383

383

Thioredoxin reductase 2

PRO_0000166772

Amino acid modifications

Disulfide bond

197 ↔ 200

Redox-active By similarity

Experimental info

Sequence conflict

308

E → Q in CAA80655. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Q39242-1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 1BA9339AE6E66FFE
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FASTA

383

40,635

        10         20         30         40         50         60 
MCWISMSQSR FIIKSLFSTA GGFLLGSALS NPPSLATAFS SSSSSSSAAA AVDMETHKTK 

        70         80         90        100        110        120 
VCIVGSGPAA HTAAIYASRA ELKPLLFEGW MANDIAPGGQ LTTTTDVENF PGFPEGILGI 

       130        140        150        160        170        180 
DIVEKFRKQS ERFGTTIFTE TVNKVDFSSK PFKLFTDSRT VLADSVIIST GAVAKRLSFT 

       190        200        210        220        230        240 
GSGEGNGGFW NRGISACAVC DGAAPIFRNK PLVVIGGGDS AMEEANFLTK YGSKVYIIHR 

       250        260        270        280        290        300 
RDTFRASKIM QQRALSNPKI EVIWNSAVVE AYGDENGRVL GGLKVKNVVT GDVSDLKVSG 

       310        320        330        340        350        360 
LFFAIGHEPA TKFLDGQLEL DEDGYVVTKP GTTKTSVVGV FAAGDVQDKK YRQAITAAGT 

       370        380 
GCMAALDAEH YLQEIGSQEG KSD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Arabidopsis thaliana NAPHP thioredoxin reductase. cDNA characterization and expression of the recombinant protein in Escherichia coli." Jacquot J.-P., Rivera-Madrid R., Marinho P., Kollarova M., le Marechal P., Miginiac-Maslow M., Meyer Y. J. Mol. Biol. 235:1357-1363(1994) [PubMed: 8308900] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-383. Tissue: Silique.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	Z23108 mRNA. Translation: CAA80655.1.
IPI	IPI00519604.
PIR	A84552. S44026.
3D structure databases
HSSP	HSSP built from PDB template 1VDC based on UniProtKB Q39243.
ModBase	Search...
Proteomic databases
PRIDE	Q39242.
Genome annotation databases
GenomeReviews	Gene locus AT2G17420 in contig CT485783_GR.
NMPDR	fig\|3702.1.peg.8732.
Organism-specific databases
TAIR	At2g17420.
Enzyme and pathway databases
BRENDA	1.8.1.9. 302.
Gene expression databases
Genevestigator	Q39242.
GermOnline	AT2G17420. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

TRXB2_ARATH

Accession

Primary (citable) accession number: Q39242
Secondary accession number(s): O22751

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 1, 2000
Last modified:	October 13, 2009
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents