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Protein

Thioredoxin H5

Gene

TRX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thiol-disulfide oxidoreductase involved in response to pathogens and oxidative stresses. Required for the response to victorin, a phytotoxin which induces programmed cell death in sensitive plants. Possesses insulin disulfide bonds reducing activity.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391NucleophileSequence analysis
Active sitei42 – 421NucleophileSequence analysis

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to oxidative stress Source: GO_Central
  • defense response to fungus Source: TAIR
  • glycerol ether metabolic process Source: InterPro
  • protein folding Source: GO_Central
  • response to cadmium ion Source: TAIR
  • response to microbial phytotoxin Source: TAIR
  • response to oxidative stress Source: TAIR
  • sulfate assimilation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H5
Short name:
AtTrxh5
Alternative name(s):
Protein LOCUS OF INSENSITIVITY TO VICTORIN 1
Thioredoxin 5
Short name:
AtTRX5
Gene namesi
Name:TRX5
Synonyms:LIV1
Ordered Locus Names:At1g45145
ORF Names:F27F5.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G45145.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • cytosol Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Insensitivity to victorin phytotoxin.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi39 – 391C → S: Loss of sensitivity to victorin phytotoxin. 1 Publication
Mutagenesisi42 – 421C → S: No effect on sensitivity to victorin phytotoxin. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 118117Thioredoxin H5PRO_0000120050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Disulfide bondi39 ↔ 42Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ39241.
PRIDEiQ39241.

PTM databases

SwissPalmiQ39241.

Expressioni

Inductioni

By treatment with salicylic acid (SA), abscisic acid (ABA), iron, copper and UV-C. Induced by wounding, oxidative stress, infection with incompatible P.syringae and treatment with the fungal phytotoxin victorin.2 Publications

Gene expression databases

GenevisibleiQ39241. AT.

Interactioni

Protein-protein interaction databases

BioGridi26307. 76 interactions.
DIPiDIP-61886N.
IntActiQ39241. 3 interactions.
STRINGi3702.AT1G45145.1.

Structurei

3D structure databases

ProteinModelPortaliQ39241.
SMRiQ39241. Positions 4-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 113112ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiQ39241.
KOiK03671.
OMAiVFMKEGN.
OrthoDBiEOG09360XJ5.
PhylomeDBiQ39241.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEGEVIAC HTLEVWNEKV KDANESKKLI VIDFTASWCP PCRFIAPVFA
60 70 80 90 100
EMAKKFTNVV FFKIDVDELQ AVAQEFKVEA MPTFVFMKEG NIIDRVVGAA
110
KDEINEKLMK HGGLVASA
Length:118
Mass (Da):13,122
Last modified:November 1, 1996 - v1
Checksum:i164FA8CDA98FC862
GO

Sequence cautioni

The sequence AAF69169 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181A → AL in AAC49356 (PubMed:8642611).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35476 mRNA. Translation: CAA84613.1.
U35829 Genomic DNA. Translation: AAC49356.1.
AC007915 Genomic DNA. Translation: AAF69169.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32083.1.
AK118035 mRNA. Translation: BAC42666.1.
AF360227 mRNA. Translation: AAK25937.1.
AY040028 mRNA. Translation: AAK64086.1.
AK221784 mRNA. Translation: BAD93909.1.
AY087159 mRNA. Translation: AAM64717.1.
PIRiG96509.
S58120.
RefSeqiNP_175128.1. NM_103588.4.
UniGeneiAt.22939.

Genome annotation databases

EnsemblPlantsiAT1G45145.1; AT1G45145.1; AT1G45145.
GeneIDi841082.
GrameneiAT1G45145.1; AT1G45145.1; AT1G45145.
KEGGiath:AT1G45145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35476 mRNA. Translation: CAA84613.1.
U35829 Genomic DNA. Translation: AAC49356.1.
AC007915 Genomic DNA. Translation: AAF69169.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32083.1.
AK118035 mRNA. Translation: BAC42666.1.
AF360227 mRNA. Translation: AAK25937.1.
AY040028 mRNA. Translation: AAK64086.1.
AK221784 mRNA. Translation: BAD93909.1.
AY087159 mRNA. Translation: AAM64717.1.
PIRiG96509.
S58120.
RefSeqiNP_175128.1. NM_103588.4.
UniGeneiAt.22939.

3D structure databases

ProteinModelPortaliQ39241.
SMRiQ39241. Positions 4-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26307. 76 interactions.
DIPiDIP-61886N.
IntActiQ39241. 3 interactions.
STRINGi3702.AT1G45145.1.

PTM databases

SwissPalmiQ39241.

Proteomic databases

PaxDbiQ39241.
PRIDEiQ39241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G45145.1; AT1G45145.1; AT1G45145.
GeneIDi841082.
GrameneiAT1G45145.1; AT1G45145.1; AT1G45145.
KEGGiath:AT1G45145.

Organism-specific databases

TAIRiAT1G45145.

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiQ39241.
KOiK03671.
OMAiVFMKEGN.
OrthoDBiEOG09360XJ5.
PhylomeDBiQ39241.

Miscellaneous databases

PROiQ39241.

Gene expression databases

GenevisibleiQ39241. AT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXH5_ARATH
AccessioniPrimary (citable) accession number: Q39241
Secondary accession number(s): Q38881, Q56X92, Q9MAJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

The active site contains a CPPC motif wich differs from the conserved CGPC motif.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.