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Protein

Thioredoxin H5

Gene

TRX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol-disulfide oxidoreductase involved in response to pathogens and oxidative stresses. Required for the response to victorin, a phytotoxin which induces programmed cell death in sensitive plants. Possesses insulin disulfide bonds reducing activity.2 Publications

Caution

The active site contains a CPPC motif wich differs from the conserved CGPC motif.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39NucleophileSequence analysis1
Active sitei42NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to oxidative stress Source: GO_Central
  • defense response to fungus Source: TAIR
  • glycerol ether metabolic process Source: InterPro
  • response to cadmium ion Source: TAIR
  • response to microbial phytotoxin Source: TAIR
  • response to oxidative stress Source: TAIR

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H5
Short name:
AtTrxh5
Alternative name(s):
Protein LOCUS OF INSENSITIVITY TO VICTORIN 1
Thioredoxin 5
Short name:
AtTRX5
Gene namesi
Name:TRX5
Synonyms:LIV1
Ordered Locus Names:At1g45145
ORF Names:F27F5.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G45145
TAIRilocus:2825451 AT1G45145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Insensitivity to victorin phytotoxin.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39C → S: Loss of sensitivity to victorin phytotoxin. 1 Publication1
Mutagenesisi42C → S: No effect on sensitivity to victorin phytotoxin. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001200502 – 118Thioredoxin H5Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Disulfide bondi39 ↔ 42Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ39241
PRIDEiQ39241

PTM databases

iPTMnetiQ39241
SwissPalmiQ39241

Expressioni

Inductioni

By treatment with salicylic acid (SA), abscisic acid (ABA), iron, copper and UV-C. Induced by wounding, oxidative stress, infection with incompatible P.syringae and treatment with the fungal phytotoxin victorin.2 Publications

Gene expression databases

ExpressionAtlasiQ39241 baseline and differential
GenevisibleiQ39241 AT

Interactioni

Protein-protein interaction databases

BioGridi26307, 76 interactors
DIPiDIP-61886N
IntActiQ39241, 4 interactors
STRINGi3702.AT1G45145.1

Structurei

3D structure databases

ProteinModelPortaliQ39241
SMRiQ39241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 113ThioredoxinPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
HOGENOMiHOG000292977
InParanoidiQ39241
KOiK03671
OMAiVIACHTI
OrthoDBiEOG09360XJ5
PhylomeDBiQ39241

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEGEVIAC HTLEVWNEKV KDANESKKLI VIDFTASWCP PCRFIAPVFA
60 70 80 90 100
EMAKKFTNVV FFKIDVDELQ AVAQEFKVEA MPTFVFMKEG NIIDRVVGAA
110
KDEINEKLMK HGGLVASA
Length:118
Mass (Da):13,122
Last modified:November 1, 1996 - v1
Checksum:i164FA8CDA98FC862
GO

Sequence cautioni

The sequence AAF69169 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118A → AL in AAC49356 (PubMed:8642611).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35476 mRNA Translation: CAA84613.1
U35829 Genomic DNA Translation: AAC49356.1
AC007915 Genomic DNA Translation: AAF69169.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32083.1
AK118035 mRNA Translation: BAC42666.1
AF360227 mRNA Translation: AAK25937.1
AY040028 mRNA Translation: AAK64086.1
AK221784 mRNA Translation: BAD93909.1
AY087159 mRNA Translation: AAM64717.1
PIRiG96509
S58120
RefSeqiNP_175128.1, NM_103588.5
UniGeneiAt.22939

Genome annotation databases

EnsemblPlantsiAT1G45145.1; AT1G45145.1; AT1G45145
GeneIDi841082
GrameneiAT1G45145.1; AT1G45145.1; AT1G45145
KEGGiath:AT1G45145

Similar proteinsi

Entry informationi

Entry nameiTRXH5_ARATH
AccessioniPrimary (citable) accession number: Q39241
Secondary accession number(s): Q38881, Q56X92, Q9MAJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health