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Protein

Thioredoxin H4

Gene

TRX4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.1 Publication

Caution

The active site contains a CPPC motif wich differs from the conserved CGPC motif.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40NucleophileSequence analysis1
Active sitei43NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H4
Short name:
AtTrxh4
Alternative name(s):
Thioredoxin 4
Short name:
AtTRX4
Gene namesi
Name:TRX4
Ordered Locus Names:At1g19730
ORF Names:F14P1.32, F6F9.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G19730
TAIRilocus:2013169 AT1G19730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200491 – 119Thioredoxin H4Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 43Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ39239

PTM databases

SwissPalmiQ39239

Expressioni

Gene expression databases

ExpressionAtlasiQ39239 baseline and differential
GenevisibleiQ39239 AT

Interactioni

Protein-protein interaction databases

BioGridi23801, 1 interactor
STRINGi3702.AT1G19730.1

Structurei

3D structure databases

ProteinModelPortaliQ39239
SMRiQ39239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 115ThioredoxinPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
HOGENOMiHOG000292977
InParanoidiQ39239
KOiK03671
OMAiSPYEQFS
OrthoDBiEOG09360XJ5
PhylomeDBiQ39239

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q39239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEGQVIG CHTNDVWTVQ LDKAKESNKL IVIDFTASWC PPCRMIAPIF
60 70 80 90 100
NDLAKKFMSS AIFFKVDVDE LQSVAKEFGV EAMPTFVFIK AGEVVDKLVG
110
ANKEDLQAKI VKHTGVTTA
Length:119
Mass (Da):13,063
Last modified:June 20, 2002 - v2
Checksum:iE2A37655F889FB24
GO

Sequence cautioni

The sequence CAA84610 differs from that shown. Reason: Frameshift at position 119.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10G → S in AAM67018 (Ref. 6) Curated1
Sequence conflicti119A → VVNQFEA in CAA84610 (PubMed:7777559).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35473 mRNA Translation: CAA84610.1 Frameshift.
AC007797 Genomic DNA Translation: AAG12565.1
AC024609 Genomic DNA No translation available.
CP002684 Genomic DNA Translation: AEE29892.1
AK118542 mRNA Translation: BAC43145.1
BT004710 mRNA Translation: AAO42956.1
AY088698 mRNA Translation: AAM67018.1
U35828 Genomic DNA Translation: AAC49355.1
PIRiD86330
S58119
RefSeqiNP_173403.1, NM_101829.4
UniGeneiAt.194

Genome annotation databases

EnsemblPlantsiAT1G19730.1; AT1G19730.1; AT1G19730
GeneIDi838562
GrameneiAT1G19730.1; AT1G19730.1; AT1G19730
KEGGiath:AT1G19730

Similar proteinsi

Entry informationi

Entry nameiTRXH4_ARATH
AccessioniPrimary (citable) accession number: Q39239
Secondary accession number(s): Q38880
, Q541W4, Q8L907, Q9FXH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 20, 2002
Last modified: April 25, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health