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Protein

Thioredoxin H4

Gene

TRX4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401NucleophileSequence analysis
Active sitei43 – 431NucleophileSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H4
Short name:
AtTrxh4
Alternative name(s):
Thioredoxin 4
Short name:
AtTRX4
Gene namesi
Name:TRX4
Ordered Locus Names:At1g19730
ORF Names:F14P1.32, F6F9.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G19730.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Thioredoxin H4PRO_0000120049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 43Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ39239.
PRIDEiQ39239.

PTM databases

SwissPalmiQ39239.

Expressioni

Gene expression databases

GenevisibleiQ39239. AT.

Interactioni

Protein-protein interaction databases

BioGridi23801. 1 interaction.
STRINGi3702.AT1G19730.1.

Structurei

3D structure databases

ProteinModelPortaliQ39239.
SMRiQ39239. Positions 3-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 115114ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiQ39239.
KOiK03671.
OMAiEFGVEAM.
OrthoDBiEOG09360XJ5.
PhylomeDBiQ39239.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEGQVIG CHTNDVWTVQ LDKAKESNKL IVIDFTASWC PPCRMIAPIF
60 70 80 90 100
NDLAKKFMSS AIFFKVDVDE LQSVAKEFGV EAMPTFVFIK AGEVVDKLVG
110
ANKEDLQAKI VKHTGVTTA
Length:119
Mass (Da):13,063
Last modified:June 20, 2002 - v2
Checksum:iE2A37655F889FB24
GO

Sequence cautioni

The sequence CAA84610 differs from that shown. Reason: Frameshift at position 119. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101G → S in AAM67018 (Ref. 6) Curated
Sequence conflicti119 – 1191A → VVNQFEA in CAA84610 (PubMed:7777559).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35473 mRNA. Translation: CAA84610.1. Frameshift.
AC007797 Genomic DNA. Translation: AAG12565.1.
AC024609 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29892.1.
AK118542 mRNA. Translation: BAC43145.1.
BT004710 mRNA. Translation: AAO42956.1.
AY088698 mRNA. Translation: AAM67018.1.
U35828 Genomic DNA. Translation: AAC49355.1.
PIRiD86330.
S58119.
RefSeqiNP_173403.1. NM_101829.3.
UniGeneiAt.194.
At.74168.

Genome annotation databases

EnsemblPlantsiAT1G19730.1; AT1G19730.1; AT1G19730.
GeneIDi838562.
GrameneiAT1G19730.1; AT1G19730.1; AT1G19730.
KEGGiath:AT1G19730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35473 mRNA. Translation: CAA84610.1. Frameshift.
AC007797 Genomic DNA. Translation: AAG12565.1.
AC024609 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29892.1.
AK118542 mRNA. Translation: BAC43145.1.
BT004710 mRNA. Translation: AAO42956.1.
AY088698 mRNA. Translation: AAM67018.1.
U35828 Genomic DNA. Translation: AAC49355.1.
PIRiD86330.
S58119.
RefSeqiNP_173403.1. NM_101829.3.
UniGeneiAt.194.
At.74168.

3D structure databases

ProteinModelPortaliQ39239.
SMRiQ39239. Positions 3-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23801. 1 interaction.
STRINGi3702.AT1G19730.1.

PTM databases

SwissPalmiQ39239.

Proteomic databases

PaxDbiQ39239.
PRIDEiQ39239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G19730.1; AT1G19730.1; AT1G19730.
GeneIDi838562.
GrameneiAT1G19730.1; AT1G19730.1; AT1G19730.
KEGGiath:AT1G19730.

Organism-specific databases

TAIRiAT1G19730.

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiQ39239.
KOiK03671.
OMAiEFGVEAM.
OrthoDBiEOG09360XJ5.
PhylomeDBiQ39239.

Miscellaneous databases

PROiQ39239.

Gene expression databases

GenevisibleiQ39239. AT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXH4_ARATH
AccessioniPrimary (citable) accession number: Q39239
Secondary accession number(s): Q38880
, Q541W4, Q8L907, Q9FXH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 20, 2002
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

The active site contains a CPPC motif wich differs from the conserved CGPC motif.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.