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Q39234

- TGA3_ARATH

UniProt

Q39234 - TGA3_ARATH

Protein

Transcription factor TGA3

Gene

TGA3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as-1 element of PR-1 promoter is salicylic acid-inducible and mediated by NPR1. Could also bind to the Hex-motif (5'-TGACGTGG-3') another cis-acting element found in plant histone promoters.1 Publication

    GO - Molecular functioni

    1. calmodulin binding Source: TAIR
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: TAIR

    GO - Biological processi

    1. defense response to bacterium Source: TAIR
    2. plant-type hypersensitive response Source: UniProtKB-KW
    3. systemic acquired resistance, salicylic acid mediated signaling pathway Source: TAIR
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Hypersensitive response, Plant defense, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor TGA3
    Alternative name(s):
    bZIP transcription factor 22
    Short name:
    AtbZIP22
    Gene namesi
    Name:TGA3
    Synonyms:BZIP22
    Ordered Locus Names:At1g22070
    ORF Names:F2E2.14
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G22070.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Transcription factor TGA3PRO_0000076555Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the whole plant.2 Publications

    Gene expression databases

    ArrayExpressiQ39234.
    GenevestigatoriQ39234.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Interacts with NPR1, NPR3 and NPR4. Interacts with GRXC7/ROXY1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRXC7Q963053EBI-541366,EBI-2257898

    Protein-protein interaction databases

    BioGridi24051. 4 interactions.
    IntActiQ39234. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39234.
    SMRiQ39234. Positions 104-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 15964bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni98 – 11821Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni124 – 13815Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili98 – 15154Sequence AnalysisAdd
    BLAST
    Coiled coili267 – 29630Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGieuNOG19618.
    HOGENOMiHOG000116597.
    InParanoidiQ39234.
    KOiK14431.
    OMAiHITIEKH.
    PhylomeDBiQ39234.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR025422. TGA_domain.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF14144. DOG1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39234-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMMSSSSST TQVVSFRDMG MYEPFQQLSG WESPFKSDIN NITSNQNNNQ    50
    SSSTTLEVDA RPEADDNNRV NYTSVYNNSL EAEPSSNNDQ DEDRINDKMK 100
    RRLAQNREAA RKSRLRKKAH VQQLEESRLK LSQLEQELVR ARQQGLCVRN 150
    SSDTSYLGPA GNMNSGIAAF EMEYTHWLEE QNRRVSEIRT ALQAHIGDIE 200
    LKMLVDSCLN HYANLFRMKA DAAKADVFFL MSGMWRTSTE RFFQWIGGFR 250
    PSELLNVVMP YVEPLTDQQL LEVRNLQQSS QQAEEALSQG LDKLQQGLVE 300
    SIAIQIKVVE SVNHGAPMAS AMENLQALES FVNQADHLRQ QTLQQMSKIL 350
    TTRQAARGLL ALGEYFHRLR ALSSLWAARP REHT 384
    Length:384
    Mass (Da):43,755
    Last modified:November 1, 1996 - v1
    Checksum:i48F965F62A2980A9
    GO

    Sequence cautioni

    The sequence AAM64781.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAF86550.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581V → F in AAM64781. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10209 mRNA. Translation: AAA32873.1.
    AC069252 Genomic DNA. Translation: AAF86550.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30193.1.
    AY087225 mRNA. Translation: AAM64781.1. Different initiation.
    PIRiF86353.
    S46523.
    RefSeqiNP_564156.1. NM_102057.3.
    UniGeneiAt.15614.

    Genome annotation databases

    EnsemblPlantsiAT1G22070.1; AT1G22070.1; AT1G22070.
    GeneIDi838812.
    KEGGiath:AT1G22070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10209 mRNA. Translation: AAA32873.1 .
    AC069252 Genomic DNA. Translation: AAF86550.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30193.1 .
    AY087225 mRNA. Translation: AAM64781.1 . Different initiation.
    PIRi F86353.
    S46523.
    RefSeqi NP_564156.1. NM_102057.3.
    UniGenei At.15614.

    3D structure databases

    ProteinModelPortali Q39234.
    SMRi Q39234. Positions 104-143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 24051. 4 interactions.
    IntActi Q39234. 4 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G22070.1 ; AT1G22070.1 ; AT1G22070 .
    GeneIDi 838812.
    KEGGi ath:AT1G22070.

    Organism-specific databases

    GeneFarmi 2993. 292.
    TAIRi AT1G22070.

    Phylogenomic databases

    eggNOGi euNOG19618.
    HOGENOMi HOG000116597.
    InParanoidi Q39234.
    KOi K14431.
    OMAi HITIEKH.
    PhylomeDBi Q39234.

    Gene expression databases

    ArrayExpressi Q39234.
    Genevestigatori Q39234.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR025422. TGA_domain.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF14144. DOG1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TGA3 is a distinct member of the TGA family of bZIP transcription factors in Arabidopsis thaliana."
      Miao Z.-H., Liu X., Lam E.
      Plant Mol. Biol. 25:1-11(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Binding site requirements and differential representation of TGF factors in nuclear ASF-1 activity."
      Lam E., Lam Y.K.
      Nucleic Acids Res. 23:3778-3785(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    6. "Binding specificity and tissue-specific expression pattern of the Arabidopsis bZIP transcription factor TGA2."
      de Pater S., Pham K., Memelink J., Kijne J.
      Mol. Gen. Genet. 250:237-239(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid."
      Zhou J.-M., Trifa Y., Silva H., Pontier D., Lam E., Shah J., Klessig D.F.
      Mol. Plant Microbe Interact. 13:191-202(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPR1.
    8. Cited for: GENE FAMILY, NOMENCLATURE.
    9. "Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis."
      Johnson C., Boden E., Arias J.
      Plant Cell 15:1846-1858(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance."
      Liu G., Holub E.B., Alonso J.M., Ecker J.R., Fobert P.R.
      Plant J. 41:304-318(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPR1 AND NPR4.
    11. "Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs."
      Zhang Y., Cheng Y.T., Qu N., Zhao Q., Bi D., Li X.
      Plant J. 48:647-656(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPR3 AND NPR4.
    12. "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana."
      Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.
      Plant Cell 21:429-441(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRXC7/ROXY1.

    Entry informationi

    Entry nameiTGA3_ARATH
    AccessioniPrimary (citable) accession number: Q39234
    Secondary accession number(s): Q8LBG4, Q9LM52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3