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Q39234

- TGA3_ARATH

UniProt

Q39234 - TGA3_ARATH

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Protein

Transcription factor TGA3

Gene

TGA3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as-1 element of PR-1 promoter is salicylic acid-inducible and mediated by NPR1. Could also bind to the Hex-motif (5'-TGACGTGG-3') another cis-acting element found in plant histone promoters.1 Publication

GO - Molecular functioni

  1. calmodulin binding Source: TAIR
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  1. defense response to bacterium Source: TAIR
  2. plant-type hypersensitive response Source: UniProtKB-KW
  3. systemic acquired resistance, salicylic acid mediated signaling pathway Source: TAIR
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Hypersensitive response, Plant defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor TGA3
Alternative name(s):
bZIP transcription factor 22
Short name:
AtbZIP22
Gene namesi
Name:TGA3
Synonyms:BZIP22
Ordered Locus Names:At1g22070
ORF Names:F2E2.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G22070.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Transcription factor TGA3PRO_0000076555Add
BLAST

Expressioni

Tissue specificityi

Expressed in the whole plant.2 Publications

Gene expression databases

ExpressionAtlasiQ39234. baseline and differential.
GenevestigatoriQ39234.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with NPR1, NPR3 and NPR4. Interacts with GRXC7/ROXY1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRXC7Q963053EBI-541366,EBI-2257898

Protein-protein interaction databases

BioGridi24051. 4 interactions.
IntActiQ39234. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ39234.
SMRiQ39234. Positions 104-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 15964bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 11821Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni124 – 13815Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili98 – 15154Sequence AnalysisAdd
BLAST
Coiled coili267 – 29630Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGieuNOG19618.
HOGENOMiHOG000116597.
InParanoidiQ39234.
KOiK14431.
OMAiHITIEKH.
PhylomeDBiQ39234.

Family and domain databases

InterProiIPR004827. bZIP.
IPR025422. TGA_domain.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF14144. DOG1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEMMSSSSST TQVVSFRDMG MYEPFQQLSG WESPFKSDIN NITSNQNNNQ
60 70 80 90 100
SSSTTLEVDA RPEADDNNRV NYTSVYNNSL EAEPSSNNDQ DEDRINDKMK
110 120 130 140 150
RRLAQNREAA RKSRLRKKAH VQQLEESRLK LSQLEQELVR ARQQGLCVRN
160 170 180 190 200
SSDTSYLGPA GNMNSGIAAF EMEYTHWLEE QNRRVSEIRT ALQAHIGDIE
210 220 230 240 250
LKMLVDSCLN HYANLFRMKA DAAKADVFFL MSGMWRTSTE RFFQWIGGFR
260 270 280 290 300
PSELLNVVMP YVEPLTDQQL LEVRNLQQSS QQAEEALSQG LDKLQQGLVE
310 320 330 340 350
SIAIQIKVVE SVNHGAPMAS AMENLQALES FVNQADHLRQ QTLQQMSKIL
360 370 380
TTRQAARGLL ALGEYFHRLR ALSSLWAARP REHT
Length:384
Mass (Da):43,755
Last modified:November 1, 1996 - v1
Checksum:i48F965F62A2980A9
GO

Sequence cautioni

The sequence AAF86550.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAM64781.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581V → F in AAM64781. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10209 mRNA. Translation: AAA32873.1.
AC069252 Genomic DNA. Translation: AAF86550.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30193.1.
AY087225 mRNA. Translation: AAM64781.1. Different initiation.
PIRiF86353.
S46523.
RefSeqiNP_564156.1. NM_102057.3.
UniGeneiAt.15614.

Genome annotation databases

EnsemblPlantsiAT1G22070.1; AT1G22070.1; AT1G22070.
GeneIDi838812.
KEGGiath:AT1G22070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10209 mRNA. Translation: AAA32873.1 .
AC069252 Genomic DNA. Translation: AAF86550.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE30193.1 .
AY087225 mRNA. Translation: AAM64781.1 . Different initiation.
PIRi F86353.
S46523.
RefSeqi NP_564156.1. NM_102057.3.
UniGenei At.15614.

3D structure databases

ProteinModelPortali Q39234.
SMRi Q39234. Positions 104-143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 24051. 4 interactions.
IntActi Q39234. 4 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G22070.1 ; AT1G22070.1 ; AT1G22070 .
GeneIDi 838812.
KEGGi ath:AT1G22070.

Organism-specific databases

GeneFarmi 2993. 292.
TAIRi AT1G22070.

Phylogenomic databases

eggNOGi euNOG19618.
HOGENOMi HOG000116597.
InParanoidi Q39234.
KOi K14431.
OMAi HITIEKH.
PhylomeDBi Q39234.

Gene expression databases

ExpressionAtlasi Q39234. baseline and differential.
Genevestigatori Q39234.

Family and domain databases

InterProi IPR004827. bZIP.
IPR025422. TGA_domain.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF14144. DOG1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TGA3 is a distinct member of the TGA family of bZIP transcription factors in Arabidopsis thaliana."
    Miao Z.-H., Liu X., Lam E.
    Plant Mol. Biol. 25:1-11(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Binding site requirements and differential representation of TGF factors in nuclear ASF-1 activity."
    Lam E., Lam Y.K.
    Nucleic Acids Res. 23:3778-3785(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  6. "Binding specificity and tissue-specific expression pattern of the Arabidopsis bZIP transcription factor TGA2."
    de Pater S., Pham K., Memelink J., Kijne J.
    Mol. Gen. Genet. 250:237-239(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid."
    Zhou J.-M., Trifa Y., Silva H., Pontier D., Lam E., Shah J., Klessig D.F.
    Mol. Plant Microbe Interact. 13:191-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPR1.
  8. Cited for: GENE FAMILY, NOMENCLATURE.
  9. "Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis."
    Johnson C., Boden E., Arias J.
    Plant Cell 15:1846-1858(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance."
    Liu G., Holub E.B., Alonso J.M., Ecker J.R., Fobert P.R.
    Plant J. 41:304-318(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPR1 AND NPR4.
  11. "Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs."
    Zhang Y., Cheng Y.T., Qu N., Zhao Q., Bi D., Li X.
    Plant J. 48:647-656(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPR3 AND NPR4.
  12. "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana."
    Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.
    Plant Cell 21:429-441(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRXC7/ROXY1.

Entry informationi

Entry nameiTGA3_ARATH
AccessioniPrimary (citable) accession number: Q39234
Secondary accession number(s): Q8LBG4, Q9LM52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3