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Protein

Syntaxin-21

Gene

SYP21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in the docking or fusion of transport vesicles with the prevacuolar membrane.

GO - Molecular functioni

  • SNAP receptor activity Source: TAIR
  • SNARE binding Source: GO_Central

GO - Biological processi

  • Golgi to vacuole transport Source: TAIR
  • late endosome to vacuole transport Source: TAIR
  • protein targeting to vacuole Source: TAIR
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-21
Short name:
AtSYP21
Alternative name(s):
PEP12 homolog
Short name:
AtPEP12
aPEP12
Gene namesi
Name:SYP21
Ordered Locus Names:At5g16830
ORF Names:F5E19_170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G16830.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 258257CytoplasmicSequence analysisAdd
BLAST
Transmembranei259 – 27921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • late endosome Source: TAIR
  • late endosome membrane Source: UniProtKB-SubCell
  • membrane Source: TAIR
  • SNARE complex Source: GO_Central
  • trans-Golgi network transport vesicle Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 279278Syntaxin-21PRO_0000210253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ39233.
PRIDEiQ39233.

PTM databases

SwissPalmiQ39233.

Expressioni

Tissue specificityi

A high level expression is seen in the roots while a low level expression is seen in the leaves.

Gene expression databases

ExpressionAtlasiQ39233. baseline and differential.
GenevisibleiQ39233. AT.

Interactioni

Subunit structurei

Interacts with VTI11 and SYP51 to form a t-SNARE complex and with alpha-SNAP to form a 20S complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VTI11Q9SEL64EBI-2352544,EBI-1162795

GO - Molecular functioni

  • SNAP receptor activity Source: TAIR
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi16822. 54 interactions.
IntActiQ39233. 52 interactions.
STRINGi3702.AT5G16830.1.

Structurei

3D structure databases

ProteinModelPortaliQ39233.
SMRiQ39233. Positions 191-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 24863t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili65 – 9430Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000188453.
InParanoidiQ39233.
KOiK08488.
OMAiSYNAPEL.
OrthoDBiEOG09360NUG.
PhylomeDBiQ39233.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQDLEAGT RSPAPNRFTG GRQQRPSSRG DPSQEVAAGI FRISTAVNSF
60 70 80 90 100
FRLVNSIGTP KDTLELRDKL QKTRLQISEL VKNTSAKLKE ASEADLHGSA
110 120 130 140 150
SQIKKIADAK LAKDFQSVLK EFQKAQRLAA EREITYTPVV TKEIPTSYNA
160 170 180 190 200
PELDTESLRI SQQQALLLQS RRQEVVFLDN EITFNEAIIE EREQGIREIE
210 220 230 240 250
DQIRDVNGMF KDLALMVNHQ GNIVDDISSN LDNSHAATTQ ATVQLRKAAK
260 270
TQRSNSSLTC LLILIFGIVL LIVIIVVLV
Length:279
Mass (Da):31,061
Last modified:November 1, 1996 - v1
Checksum:iEDAB4B07CC377CE3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → T in AAM66128 (Ref. 5) Curated
Sequence conflicti263 – 2631I → T in AAM66128 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41651 mRNA. Translation: AAA87296.1.
AL391147 Genomic DNA. Translation: CAC01847.1.
CP002688 Genomic DNA. Translation: AED92345.1.
AF411797 mRNA. Translation: AAL06486.1.
AY088599 mRNA. Translation: AAM66128.1.
PIRiT51515.
RefSeqiNP_197185.1. NM_121689.3.
UniGeneiAt.1639.
At.5364.

Genome annotation databases

EnsemblPlantsiAT5G16830.1; AT5G16830.1; AT5G16830.
GeneIDi831546.
GrameneiAT5G16830.1; AT5G16830.1; AT5G16830.
KEGGiath:AT5G16830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41651 mRNA. Translation: AAA87296.1.
AL391147 Genomic DNA. Translation: CAC01847.1.
CP002688 Genomic DNA. Translation: AED92345.1.
AF411797 mRNA. Translation: AAL06486.1.
AY088599 mRNA. Translation: AAM66128.1.
PIRiT51515.
RefSeqiNP_197185.1. NM_121689.3.
UniGeneiAt.1639.
At.5364.

3D structure databases

ProteinModelPortaliQ39233.
SMRiQ39233. Positions 191-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16822. 54 interactions.
IntActiQ39233. 52 interactions.
STRINGi3702.AT5G16830.1.

PTM databases

SwissPalmiQ39233.

Proteomic databases

PaxDbiQ39233.
PRIDEiQ39233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G16830.1; AT5G16830.1; AT5G16830.
GeneIDi831546.
GrameneiAT5G16830.1; AT5G16830.1; AT5G16830.
KEGGiath:AT5G16830.

Organism-specific databases

TAIRiAT5G16830.

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000188453.
InParanoidiQ39233.
KOiK08488.
OMAiSYNAPEL.
OrthoDBiEOG09360NUG.
PhylomeDBiQ39233.

Miscellaneous databases

PROiQ39233.

Gene expression databases

ExpressionAtlasiQ39233. baseline and differential.
GenevisibleiQ39233. AT.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYP21_ARATH
AccessioniPrimary (citable) accession number: Q39233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.