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Protein

Sugar transport protein 4

Gene

STP4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, methylglucose, galactose, xylose and mannose, but not fructose.1 Publication

Kineticsi

  1. KM=15 µM for glucose
  2. KM=100 µM for 3-O-methylglucose

    GO - Molecular functioni

    • glucose transmembrane transporter activity Source: GO_Central
    • monosaccharide transmembrane transporter activity Source: TAIR
    • sucrose:proton symporter activity Source: TAIR

    GO - Biological processi

    • glucose import Source: GO_Central
    • sucrose transport Source: TAIR

    Keywordsi

    Biological processSugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.49 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 4
    Alternative name(s):
    Hexose transporter 4
    Gene namesi
    Name:STP4
    Ordered Locus Names:At3g19930
    ORF Names:MPN9.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    AraportiAT3G19930
    TAIRilocus:2092286 AT3G19930

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
    Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei172 – 192Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei202 – 222Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei321 – 341Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei348 – 368Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei387 – 407Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei426 – 446Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei451 – 471Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini472 – 514CytoplasmicSequence analysisAdd BLAST43

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504341 – 514Sugar transport protein 4Add BLAST514

    Proteomic databases

    PaxDbiQ39228
    PRIDEiQ39228

    Expressioni

    Tissue specificityi

    Mostly in flowers and roots, especially in anthers, including pollen, and root tips. Also present in some hydathodes.2 Publications

    Inductioni

    Induced locally by wounding, elicitors such as chitin, bacterial pathogens such as P.syringae, compatible fungal pathogens such as A.brassicicola, E.cichoracearum and F.oxysporum, and incompatible fungal pathogens such as B.graminis. Also induced by aphid feeding.3 Publications

    Gene expression databases

    ExpressionAtlasiQ39228 baseline and differential
    GenevisibleiQ39228 AT

    Interactioni

    Protein-protein interaction databases

    BioGridi6863, 19 interactors
    IntActiQ39228, 1 interactor
    STRINGi3702.AT3G19930.1

    Structurei

    3D structure databases

    ProteinModelPortaliQ39228
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi454 – 460Poly-Phe7

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    HOGENOMiHOG000202867
    InParanoidiQ39228
    OMAiCTILGIM
    OrthoDBiEOG093608DR
    PhylomeDBiQ39228

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00879 SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q39228-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAGGFVSQTP GVRNYNYKLT PKVFVTCFIG AFGGLIFGYD LGISGGVTSM
    60 70 80 90 100
    EPFLEEFFPY VYKKMKSAHE NEYCRFDSQL LTLFTSSLYV AALVSSLFAS
    110 120 130 140 150
    TITRVFGRKW SMFLGGFTFF IGSAFNGFAQ NIAMLLIGRI LLGFGVGFAN
    160 170 180 190 200
    QSVPVYLSEM APPNLRGAFN NGFQVAIIFG IVVATIINYF TAQMKGNIGW
    210 220 230 240 250
    RISLGLACVP AVMIMIGALI LPDTPNSLIE RGYTEEAKEM LQSIRGTNEV
    260 270 280 290 300
    DEEFQDLIDA SEESKQVKHP WKNIMLPRYR PQLIMTCFIP FFQQLTGINV
    310 320 330 340 350
    ITFYAPVLFQ TLGFGSKASL LSAMVTGIIE LLCTFVSVFT VDRFGRRILF
    360 370 380 390 400
    LQGGIQMLVS QIAIGAMIGV KFGVAGTGNI GKSDANLIVA LICIYVAGFA
    410 420 430 440 450
    WSWGPLGWLV PSEISPLEIR SAAQAINVSV NMFFTFLVAQ LFLTMLCHMK
    460 470 480 490 500
    FGLFFFFAFF VVIMTIFIYL MLPETKNVPI EEMNRVWKAH WFWGKFIPDE
    510
    AVNMGAAEMQ QKSV
    Length:514
    Mass (Da):57,095
    Last modified:November 1, 1996 - v1
    Checksum:i33C6104CA2E455B1
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X66857 mRNA Translation: CAA47325.1
    AB025631 Genomic DNA Translation: BAB01308.1
    CP002686 Genomic DNA Translation: AEE76309.1
    CP002686 Genomic DNA Translation: ANM64813.1
    AF367352 mRNA Translation: AAK32938.1
    AF428342 mRNA Translation: AAL16272.1
    AY133592 mRNA Translation: AAM91422.1
    AK220712 mRNA Translation: BAD93826.1
    PIRiS25009
    RefSeqiNP_001326818.1, NM_001338428.1
    NP_188627.1, NM_112883.5
    UniGeneiAt.187

    Genome annotation databases

    EnsemblPlantsiAT3G19930.1; AT3G19930.1; AT3G19930
    AT3G19930.2; AT3G19930.2; AT3G19930
    GeneIDi821531
    GrameneiAT3G19930.1; AT3G19930.1; AT3G19930
    AT3G19930.2; AT3G19930.2; AT3G19930
    KEGGiath:AT3G19930

    Similar proteinsi

    Entry informationi

    Entry nameiSTP4_ARATH
    AccessioniPrimary (citable) accession number: Q39228
    Secondary accession number(s): Q570J6
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: November 1, 1996
    Last modified: May 23, 2018
    This is version 118 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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