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Protein

Sugar transport protein 4

Gene

STP4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, methylglucose, galactose, xylose and mannose, but not fructose.1 Publication

Kineticsi

  1. KM=15 µM for glucose
  2. KM=100 µM for 3-O-methylglucose

    GO - Molecular functioni

    • glucose transmembrane transporter activity Source: GO_Central
    • monosaccharide transmembrane transporter activity Source: TAIR
    • sucrose:proton symporter activity Source: TAIR

    GO - Biological processi

    • glucose import Source: GO_Central
    • hexose transmembrane transport Source: GO_Central
    • sucrose transport Source: TAIR
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.49. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 4
    Alternative name(s):
    Hexose transporter 4
    Gene namesi
    Name:STP4
    Ordered Locus Names:At3g19930
    ORF Names:MPN9.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    TAIRiAT3G19930.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
    BLAST
    Transmembranei172 – 19221Helical; Name=5Sequence analysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=6Sequence analysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=7Sequence analysisAdd
    BLAST
    Transmembranei321 – 34121Helical; Name=8Sequence analysisAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=9Sequence analysisAdd
    BLAST
    Transmembranei387 – 40721Helical; Name=10Sequence analysisAdd
    BLAST
    Transmembranei426 – 44621Helical; Name=11Sequence analysisAdd
    BLAST
    Transmembranei451 – 47121Helical; Name=12Sequence analysisAdd
    BLAST
    Topological domaini472 – 51443CytoplasmicSequence analysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Sugar transport protein 4PRO_0000050434Add
    BLAST

    Proteomic databases

    PaxDbiQ39228.
    PRIDEiQ39228.

    Expressioni

    Tissue specificityi

    Mostly in flowers and roots, especially in anthers, including pollen, and root tips. Also present in some hydathodes.2 Publications

    Inductioni

    Induced locally by wounding, elicitors such as chitin, bacterial pathogens such as P.syringae, compatible fungal pathogens such as A.brassicicola, E.cichoracearum and F.oxysporum, and incompatible fungal pathogens such as B.graminis. Also induced by aphid feeding.3 Publications

    Gene expression databases

    GenevisibleiQ39228. AT.

    Interactioni

    Protein-protein interaction databases

    BioGridi6863. 19 interactions.
    STRINGi3702.AT3G19930.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39228.
    SMRiQ39228. Positions 23-488.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi454 – 4607Poly-Phe

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ39228.
    OMAiGAMIGVK.
    PhylomeDBiQ39228.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport_like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39228-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAGGFVSQTP GVRNYNYKLT PKVFVTCFIG AFGGLIFGYD LGISGGVTSM
    60 70 80 90 100
    EPFLEEFFPY VYKKMKSAHE NEYCRFDSQL LTLFTSSLYV AALVSSLFAS
    110 120 130 140 150
    TITRVFGRKW SMFLGGFTFF IGSAFNGFAQ NIAMLLIGRI LLGFGVGFAN
    160 170 180 190 200
    QSVPVYLSEM APPNLRGAFN NGFQVAIIFG IVVATIINYF TAQMKGNIGW
    210 220 230 240 250
    RISLGLACVP AVMIMIGALI LPDTPNSLIE RGYTEEAKEM LQSIRGTNEV
    260 270 280 290 300
    DEEFQDLIDA SEESKQVKHP WKNIMLPRYR PQLIMTCFIP FFQQLTGINV
    310 320 330 340 350
    ITFYAPVLFQ TLGFGSKASL LSAMVTGIIE LLCTFVSVFT VDRFGRRILF
    360 370 380 390 400
    LQGGIQMLVS QIAIGAMIGV KFGVAGTGNI GKSDANLIVA LICIYVAGFA
    410 420 430 440 450
    WSWGPLGWLV PSEISPLEIR SAAQAINVSV NMFFTFLVAQ LFLTMLCHMK
    460 470 480 490 500
    FGLFFFFAFF VVIMTIFIYL MLPETKNVPI EEMNRVWKAH WFWGKFIPDE
    510
    AVNMGAAEMQ QKSV
    Length:514
    Mass (Da):57,095
    Last modified:November 1, 1996 - v1
    Checksum:i33C6104CA2E455B1
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X66857 mRNA. Translation: CAA47325.1.
    AB025631 Genomic DNA. Translation: BAB01308.1.
    CP002686 Genomic DNA. Translation: AEE76309.1.
    AF367352 mRNA. Translation: AAK32938.1.
    AF428342 mRNA. Translation: AAL16272.1.
    AY133592 mRNA. Translation: AAM91422.1.
    AK220712 mRNA. Translation: BAD93826.1.
    PIRiS25009.
    RefSeqiNP_188627.1. NM_112883.4.
    UniGeneiAt.187.

    Genome annotation databases

    EnsemblPlantsiAT3G19930.1; AT3G19930.1; AT3G19930.
    GeneIDi821531.
    GrameneiAT3G19930.1; AT3G19930.1; AT3G19930.
    KEGGiath:AT3G19930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X66857 mRNA. Translation: CAA47325.1.
    AB025631 Genomic DNA. Translation: BAB01308.1.
    CP002686 Genomic DNA. Translation: AEE76309.1.
    AF367352 mRNA. Translation: AAK32938.1.
    AF428342 mRNA. Translation: AAL16272.1.
    AY133592 mRNA. Translation: AAM91422.1.
    AK220712 mRNA. Translation: BAD93826.1.
    PIRiS25009.
    RefSeqiNP_188627.1. NM_112883.4.
    UniGeneiAt.187.

    3D structure databases

    ProteinModelPortaliQ39228.
    SMRiQ39228. Positions 23-488.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi6863. 19 interactions.
    STRINGi3702.AT3G19930.1.

    Protein family/group databases

    TCDBi2.A.1.1.49. the major facilitator superfamily (mfs).

    Proteomic databases

    PaxDbiQ39228.
    PRIDEiQ39228.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT3G19930.1; AT3G19930.1; AT3G19930.
    GeneIDi821531.
    GrameneiAT3G19930.1; AT3G19930.1; AT3G19930.
    KEGGiath:AT3G19930.

    Organism-specific databases

    TAIRiAT3G19930.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ39228.
    OMAiGAMIGVK.
    PhylomeDBiQ39228.

    Miscellaneous databases

    PROiQ39228.

    Gene expression databases

    GenevisibleiQ39228. AT.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport_like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "The sink-specific and stress-regulated Arabidopsis STP4 gene: enhanced expression of a gene encoding a monosaccharide transporter by wounding, elicitors, and pathogen challenge."
      Truernit E., Schmid J., Epple P., Illig J., Sauer N.
      Plant Cell 8:2169-2182(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 430-514.
      Strain: cv. Columbia.
    6. "Molecular responses to aphid feeding in Arabidopsis in relation to plant defense pathways."
      Moran P.J., Thompson G.A.
      Plant Physiol. 125:1074-1085(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "The monosaccharide transporter gene, AtSTP4, and the cell-wall invertase, Atbetafruct1, are induced in Arabidopsis during infection with the fungal biotroph Erysiphe cichoracearum."
      Fotopoulos V., Gilbert M.J., Pittman J.K., Marvier A.C., Buchanan A.J., Sauer N., Hall J.L., Williams L.E.
      Plant Physiol. 132:821-829(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY.
    8. "The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages."
      Johnson D.A., Hill J.P., Thomas M.A.
      BMC Evol. Biol. 6:64-64(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiSTP4_ARATH
    AccessioniPrimary (citable) accession number: Q39228
    Secondary accession number(s): Q570J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: November 1, 1996
    Last modified: July 6, 2016
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.