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Protein

SEC12-like protein 2

Gene

STL2P

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the formation or budding of transport vesicles from the ER.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: TAIR
  • protein secretion Source: GO_Central
  • regulation of COPII vesicle coating Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
SEC12-like protein 2
Gene namesi
Name:STL2P
Synonyms:ST12P
Ordered Locus Names:At2g01470
ORF Names:F2I9.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G01470.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 367CytoplasmicSequence analysisAdd BLAST366
Transmembranei368 – 388Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini389 – 393LumenalSequence analysis5

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of endoplasmic reticulum membrane Source: TAIR
  • membrane Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000512292 – 393SEC12-like protein 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ39221.

PTM databases

iPTMnetiQ39221.

Expressioni

Gene expression databases

GenevisibleiQ39221. AT.

Interactioni

Subunit structurei

Interacts with BZIP28.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi78. 1 interactor.
STRINGi3702.AT2G01470.1.

Structurei

3D structure databases

ProteinModelPortaliQ39221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati151 – 190WD 1Add BLAST40
Repeati193 – 231WD 2Add BLAST39
Repeati283 – 322WD 3Add BLAST40
Repeati326 – 367WD 4Add BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 58Poly-Ser10

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

eggNOGiKOG0771. Eukaryota.
ENOG410XRQK. LUCA.
HOGENOMiHOG000070543.
InParanoidiQ39221.
KOiK14003.
OMAiYRWESQE.
OrthoDBiEOG09360GBW.
PhylomeDBiQ39221.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQSTETNQ PSNMQTYGVP IYAADWIPEV DVRSKIIMDP EKSEDDDESS
60 70 80 90 100
SSSSSSRSCI VLSGGGGEGR SGISNVILIC RVDLNTNSLS EQPLGRLVVG
110 120 130 140 150
SDLPYRMAVH PREGGLICAL PNSCKLFHWE DIMSREDNQA GESEEVIKEL
160 170 180 190 200
RDVGQQLALA FNPEGSVLAA GAEDGTLRVF KWPSMNTLLN ESQAHSSVKC
210 220 230 240 250
LTFSESGQFL VSLGGPVCRV WDVNASAAVA SLSKEKDEMF ASCRFSVDSA
260 270 280 290 300
GNEVLYIAAN TERGGSIITC DTKLWKRKWS KPIKKNSISA FNVSADGKLL
310 320 330 340 350
AIGTLEGDVL ILESTRMQTI QVVKKAHLGL VTALTFSPDS RGLVSVSFDS
360 370 380 390
RARLTMIEQK GDKPGVRWWL LVLLIVLLYV VAYYYMKAKG IIP
Length:393
Mass (Da):42,794
Last modified:January 10, 2006 - v4
Checksum:iD076454309A15013
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti322V → I in AAA32871 (PubMed:1396601).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95796 mRNA. Translation: AAA32871.1.
AC005560 Genomic DNA. Translation: AAC67323.1.
CP002685 Genomic DNA. Translation: AEC05458.1.
AY065198 mRNA. Translation: AAL38374.1.
AY074332 mRNA. Translation: AAL67028.1.
AY123030 mRNA. Translation: AAM67563.1.
PIRiB84425.
S28604.
T48907.
RefSeqiNP_178256.1. NM_126208.4.
UniGeneiAt.323.

Genome annotation databases

EnsemblPlantsiAT2G01470.1; AT2G01470.1; AT2G01470.
GeneIDi814675.
GrameneiAT2G01470.1; AT2G01470.1; AT2G01470.
KEGGiath:AT2G01470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95796 mRNA. Translation: AAA32871.1.
AC005560 Genomic DNA. Translation: AAC67323.1.
CP002685 Genomic DNA. Translation: AEC05458.1.
AY065198 mRNA. Translation: AAL38374.1.
AY074332 mRNA. Translation: AAL67028.1.
AY123030 mRNA. Translation: AAM67563.1.
PIRiB84425.
S28604.
T48907.
RefSeqiNP_178256.1. NM_126208.4.
UniGeneiAt.323.

3D structure databases

ProteinModelPortaliQ39221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78. 1 interactor.
STRINGi3702.AT2G01470.1.

PTM databases

iPTMnetiQ39221.

Proteomic databases

PaxDbiQ39221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G01470.1; AT2G01470.1; AT2G01470.
GeneIDi814675.
GrameneiAT2G01470.1; AT2G01470.1; AT2G01470.
KEGGiath:AT2G01470.

Organism-specific databases

TAIRiAT2G01470.

Phylogenomic databases

eggNOGiKOG0771. Eukaryota.
ENOG410XRQK. LUCA.
HOGENOMiHOG000070543.
InParanoidiQ39221.
KOiK14003.
OMAiYRWESQE.
OrthoDBiEOG09360GBW.
PhylomeDBiQ39221.

Enzyme and pathway databases

ReactomeiR-ATH-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

PROiQ39221.

Gene expression databases

GenevisibleiQ39221. AT.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTLP2_ARATH
AccessioniPrimary (citable) accession number: Q39221
Secondary accession number(s): Q7EP29, Q8VZ72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

In the process of transport, may migrate to the Golgi apparatus and function in subsequent transport events.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.