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Q39219

- AOX1A_ARATH

UniProt

Q39219 - AOX1A_ARATH

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Protein

Ubiquinol oxidase 1a, mitochondrial

Gene

AOX1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. Increases respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.3 Publications

Catalytic activityi

2 ubiquinol + O2 = 2 ubiquinone + 2 H2O.1 Publication

Cofactori

Binds 2 iron ions per subunit.3 Publications

Enzyme regulationi

When the two monomeric subunits are covalently linked by a S-S bond, the enzyme is essentially inactive. When the disulfide bond is reduced, its component sulfhydryls can associate with K-keto acids through formation of a thiohemiacetal, resulting in enzyme activation. Activated by glyoxylate, irrespective to the substitution found at Cys-127. That suggests the presence of a second activation site, possibly Cys-177.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831IronSequence Analysis
Metal bindingi222 – 2221IronSequence Analysis
Metal bindingi225 – 2251IronSequence Analysis
Metal bindingi274 – 2741IronSequence Analysis
Metal bindingi324 – 3241IronSequence Analysis
Metal bindingi327 – 3271IronSequence Analysis

GO - Molecular functioni

  1. alternative oxidase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular respiration Source: TAIR
  2. mitochondria-nucleus signaling pathway Source: TAIR
  3. response to cold Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:AT3G22370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinol oxidase 1a, mitochondrial (EC:1.10.3.11)
Alternative name(s):
Alternative oxidase 1a
Gene namesi
Name:AOX1A
Synonyms:AOX1, HSR3
Ordered Locus Names:At3g22370
ORF Names:MCB17.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G22370.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. mitochondrion Source: TAIR
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions. Decreased operating efficiency of photosystem II and an enhanced activity of cyclic electron transport around photosystem I. Altered photosynthetic carbon metabolism when grown under high CO2 concentrations.4 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi127 – 1271C → A, L or Q: Loss of activity and stimulation by pyruvate. 3 Publications
Mutagenesisi127 – 1271C → E, D, R or K: Active enzyme insensitive to stimulation by pyruvate. 3 Publications
Mutagenesisi127 – 1271C → S: Loss of oxidative inactivation and stimulation by pyruvate, but can be activated by succinate. 3 Publications
Mutagenesisi177 – 1771C → A: No effect on stimulation by pyruvate. 1 Publication
Mutagenesisi264 – 2641F → L: Increased resistance to a substrate-analog inhibitor. 1 Publication
Mutagenesisi268 – 2681M → I or V: Increased resistance to a substrate-analog inhibitor. 1 Publication
Mutagenesisi352 – 3521G → E: Increased resistance to a substrate-analog inhibitor. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6262MitochondrionSequence AnalysisAdd
BLAST
Chaini63 – 354292Ubiquinol oxidase 1a, mitochondrialPRO_0000001731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi127 – 127Interchain1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ39219.
PRIDEiQ39219.

Expressioni

Tissue specificityi

Expressed in roots, stems, cotyledons, leaves and flowers. High expression in sepals.3 Publications

Developmental stagei

Expressed throughout development. Low expression during 48 hours after imbibition and then increases.2 Publications

Inductioni

Up-regulated by antimycin A, low-nitrogen and salt stresses, high light, H2O2, ethylene, paraquat, rotenone, salicylic acid, malonate,erythromycin and cold treatments.10 Publications

Gene expression databases

GenevestigatoriQ39219.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

IntActiQ39219. 1 interaction.
STRINGi3702.AT3G22370.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ39219.
SMRiQ39219. Positions 145-338.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the alternative oxidase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80852.
HOGENOMiHOG000178442.
InParanoidiQ39219.
KOiK17893.
OMAiTEWKWNC.
PhylomeDBiQ39219.

Family and domain databases

InterProiIPR002680. AOX.
[Graphical view]
PfamiPF01786. AOX. 1 hit.
[Graphical view]
PIRSFiPIRSF005229. AOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39219-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMITRGGAKA AKSLLVAAGP RLFSTVRTVS SHEALSASHI LKPGVTSAWI
60 70 80 90 100
WTRAPTIGGM RFASTITLGE KTPMKEEDAN QKKTENESTG GDAAGGNNKG
110 120 130 140 150
DKGIASYWGV EPNKITKEDG SEWKWNCFRP WETYKADITI DLKKHHVPTT
160 170 180 190 200
FLDRIAYWTV KSLRWPTDLF FQRRYGCRAM MLETVAAVPG MVGGMLLHCK
210 220 230 240 250
SLRRFEQSGG WIKALLEEAE NERMHLMTFM EVAKPKWYER ALVITVQGVF
260 270 280 290 300
FNAYFLGYLI SPKFAHRMVG YLEEEAIHSY TEFLKELDKG NIENVPAPAI
310 320 330 340 350
AIDYWRLPAD ATLRDVVMVV RADEAHHRDV NHFASDIHYQ GRELKEAPAP

IGYH
Length:354
Mass (Da):39,980
Last modified:December 15, 1998 - v2
Checksum:i6DA19881E8BC9382
GO

Sequence cautioni

The sequence CAA10364.1 differs from that shown. Reason: Frameshift at position 6.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371A → R in CAA10364. (PubMed:10518009)Curated
Sequence conflicti50 – 512IW → MD in AAA32870. (PubMed:1438286)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89875 Genomic DNA. Translation: BAA22625.1.
AJ131392 mRNA. Translation: CAA10364.1. Frameshift.
AB022215 Genomic DNA. Translation: BAB01775.1.
CP002686 Genomic DNA. Translation: AEE76627.1.
AF370166 mRNA. Translation: AAK43981.1.
AY059128 mRNA. Translation: AAL15234.1.
M96417 mRNA. Translation: AAA32870.1.
U85244 Genomic DNA. Translation: AAB49302.1.
PIRiA46364.
T51615.
RefSeqiNP_188876.1. NM_113135.3.
UniGeneiAt.23475.

Genome annotation databases

EnsemblPlantsiAT3G22370.1; AT3G22370.1; AT3G22370.
GeneIDi821806.
KEGGiath:AT3G22370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89875 Genomic DNA. Translation: BAA22625.1 .
AJ131392 mRNA. Translation: CAA10364.1 . Frameshift.
AB022215 Genomic DNA. Translation: BAB01775.1 .
CP002686 Genomic DNA. Translation: AEE76627.1 .
AF370166 mRNA. Translation: AAK43981.1 .
AY059128 mRNA. Translation: AAL15234.1 .
M96417 mRNA. Translation: AAA32870.1 .
U85244 Genomic DNA. Translation: AAB49302.1 .
PIRi A46364.
T51615.
RefSeqi NP_188876.1. NM_113135.3.
UniGenei At.23475.

3D structure databases

ProteinModelPortali Q39219.
SMRi Q39219. Positions 145-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q39219. 1 interaction.
STRINGi 3702.AT3G22370.1-P.

Proteomic databases

PaxDbi Q39219.
PRIDEi Q39219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G22370.1 ; AT3G22370.1 ; AT3G22370 .
GeneIDi 821806.
KEGGi ath:AT3G22370.

Organism-specific databases

GeneFarmi 1749. 131.
TAIRi AT3G22370.

Phylogenomic databases

eggNOGi NOG80852.
HOGENOMi HOG000178442.
InParanoidi Q39219.
KOi K17893.
OMAi TEWKWNC.
PhylomeDBi Q39219.

Enzyme and pathway databases

BioCyci MetaCyc:AT3G22370-MONOMER.

Gene expression databases

Genevestigatori Q39219.

Family and domain databases

InterProi IPR002680. AOX.
[Graphical view ]
Pfami PF01786. AOX. 1 hit.
[Graphical view ]
PIRSFi PIRSF005229. AOX. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the gene family for alternative oxidase from Arabidopsis thaliana."
    Saisho D., Nambara E., Naito S., Tsutsumi N., Hirai A., Nakazono M.
    Plant Mol. Biol. 35:585-596(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION BY ANTIMYCIN A, TISSUE SPECIFICITY.
    Strain: cv. Columbia.
    Tissue: Leaf and Stem.
  2. "Identification of new early markers of the hypersensitive response in Arabidopsis thaliana."
    Lacomme C.J., Roby D.
    FEBS Lett. 459:149-153(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Arabidopsis alternative oxidase sustains Escherichia coli respiration."
    Kumar A.M., Soell D.
    Proc. Natl. Acad. Sci. U.S.A. 89:10842-10846(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-354, FUNCTION.
  7. Johnson Potter F., Wiskich J.T.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-354.
  8. "The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center."
    Siedow J.N., Umbach A.L., Moore A.L.
    FEBS Lett. 362:10-14(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: IRON-BINDING SITES, COFACTOR.
  9. "Isolation of mutants of the Arabidopsis thaliana alternative oxidase (ubiquinol:oxygen oxidoreductase) resistant to salicylhydroxamic acid."
    Berthold D.A.
    Biochim. Biophys. Acta 1364:73-83(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF PHE-264; MET-268 AND GLY-352.
  10. "Regulation of the cyanide-resistant alternative oxidase of plant mitochondria. Identification of the cysteine residue involved in alpha-keto acid stimulation and intersubunit disulfide bond formation."
    Rhoads D.M., Umbach A.L., Sweet C.R., Lennon A.M., Rauch G.S., Siedow J.N.
    J. Biol. Chem. 273:30750-30756(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-127 AND CYS-177, SUBUNIT, DISULFIDE BOND, ENZYME REGULATION.
  11. "A revised model of the active site of alternative oxidase."
    Andersson M.E., Nordlund P.
    FEBS Lett. 449:17-22(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IRON-BINDING SITES, COFACTOR.
  12. "A single amino acid change in the plant alternative oxidase alters the specificity of organic acid activation."
    Djajanegara I., Holtzapffel R., Finnegan P.M., Hoefnagel M.H., Berthold D.A., Wiskich J.T., Day D.A.
    FEBS Lett. 454:220-224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-127, ENZYME REGULATION.
  13. "New insight into the structure and function of the alternative oxidase."
    Berthold D.A., Andersson M.E., Nordlund P.
    Biochim. Biophys. Acta 1460:241-254(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IRON-BINDING SITES, COFACTOR.
  14. "The gene for alternative oxidase-2 (AOX2) from Arabidopsis thaliana consists of five exons unlike other AOX genes and is transcribed at an early stage during germination."
    Saisho D., Nakazono M., Lee K.-H., Tsutsumi N., Akita S., Hirai A.
    Genes Genet. Syst. 76:89-97(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, INDUCTION BY ANTIMYCIN A.
    Strain: cv. Columbia GL1.
  15. "Activation of the plant mitochondrial alternative oxidase: insights from site-directed mutagenesis."
    Umbach A.L., Gonzalez-Meler M.A., Sweet C.R., Siedow J.N.
    Biochim. Biophys. Acta 1554:118-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-127, INDUCTION BY GLYOXLATE.
  16. "EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center."
    Berthold D.A., Voevodskaya N., Stenmark P., Graslund A., Nordlund P.
    J. Biol. Chem. 277:43608-43614(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: EPR SPECTROSCOPY.
  17. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  18. "Stress-induced co-expression of alternative respiratory chain components in Arabidopsis thaliana."
    Clifton R., Lister R., Parker K.L., Sappl P.G., Elhafez D., Millar A.H., Day D.A., Whelan J.
    Plant Mol. Biol. 58:193-212(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY ABIOTIC STRESSES.
  19. "The alternative oxidase of plant mitochondria is involved in the acclimation of shoot growth at low temperature. A study of Arabidopsis AOX1a transgenic plants."
    Fiorani F., Umbach A.L., Siedow J.N.
    Plant Physiol. 139:1795-1805(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "Alternative oxidases in Arabidopsis: a comparative analysis of differential expression in the gene family provides new insights into function of non-phosphorylating bypasses."
    Clifton R., Millar A.H., Whelan J.
    Biochim. Biophys. Acta 1757:730-741(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  21. "Characterization of mitochondrial alternative NAD(P)H dehydrogenases in Arabidopsis: intraorganelle location and expression."
    Elhafez D., Murcha M.W., Clifton R., Soole K.L., Day D.A., Whelan J.
    Plant Cell Physiol. 47:43-54(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  22. "Alternative oxidase involvement in cold stress response of Arabidopsis thaliana fad2 and FAD3+ cell suspensions altered in membrane lipid composition."
    Matos A.R., Hourton-Cabassa C., Cicek D., Reze N., Arrabaca J.D., Zachowski A., Moreau F.
    Plant Cell Physiol. 48:856-865(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY COLD.
  23. "Induction of the AOX1D isoform of alternative oxidase in A. thaliana T-DNA insertion lines lacking isoform AOX1A is insufficient to optimize photosynthesis when treated with antimycin A."
    Strodtkoetter I., Padmasree K., Dinakar C., Speth B., Niazi P.S., Wojtera J., Voss I., Do P.T., Nunes-Nesi A., Fernie A.R., Linke V., Raghavendra A.S., Scheibe R.
    Mol. Plant 2:284-297(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  24. "Differential gene expression profiles of the mitochondrial respiratory components in illuminated Arabidopsis leaves."
    Yoshida K., Noguchi K.
    Plant Cell Physiol. 50:1449-1462(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HIGH LIGHT.
  25. "Effects of AOX1a deficiency on plant growth, gene expression of respiratory components and metabolic profile under low-nitrogen stress in Arabidopsis thaliana."
    Watanabe C.K., Hachiya T., Takahara K., Kawai-Yamada M., Uchimiya H., Uesono Y., Terashima I., Noguchi K.
    Plant Cell Physiol. 51:810-822(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY LOW-NITROGEN STRESS, DISRUPTION PHENOTYPE.
  26. "Involvement of ethylene and hydrogen peroxide in induction of alternative respiratory pathway in salt-treated Arabidopsis calluses."
    Wang H., Liang X., Huang J., Zhang D., Lu H., Liu Z., Bi Y.
    Plant Cell Physiol. 51:1754-1765(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY SALT STRESS; H(2)O(2) AND ETHYLENE.
  27. "Physiological impact of mitochondrial alternative oxidase on photosynthesis and growth in Arabidopsis thaliana."
    Yoshida K., Watanabe C.K., Terashima I., Noguchi K.
    Plant Cell Environ. 34:1890-1899(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  28. "Involvement of hydrogen peroxide, calcium, and ethylene in the induction of the alternative pathway in chilling-stressed Arabidopsis callus."
    Wang H., Huang J., Liang X., Bi Y.
    Planta 235:53-67(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY COLD AND ETHYLENE.
  29. "The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO2 in Arabidopsis thaliana."
    Gandin A., Duffes C., Day D.A., Cousins A.B.
    Plant Cell Physiol. 53:1627-1637(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiAOX1A_ARATH
AccessioniPrimary (citable) accession number: Q39219
Secondary accession number(s): O23914, P93734, Q9ZRT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Cys-127 is involved in the sulfhydryl/disulfide regulation system, but is not required for subunit dimerization. Presence of a positive charge at this residue 127 confers activity while an uncharged substitution creates an inactive enzyme (PubMed:9804851, PubMed:12034477).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3