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Q39219

- AOX1A_ARATH

UniProt

Q39219 - AOX1A_ARATH

Protein

Ubiquinol oxidase 1a, mitochondrial

Gene

AOX1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. Increases respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.3 Publications

    Catalytic activityi

    2 ubiquinol + O2 = 2 ubiquinone + 2 H2O.1 Publication

    Cofactori

    Binds 2 iron ions per subunit.3 Publications

    Enzyme regulationi

    When the two monomeric subunits are covalently linked by a S-S bond, the enzyme is essentially inactive. When the disulfide bond is reduced, its component sulfhydryls can associate with K-keto acids through formation of a thiohemiacetal, resulting in enzyme activation. Activated by glyoxylate, irrespective to the substitution found at Cys-127. That suggests the presence of a second activation site, possibly Cys-177.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi183 – 1831IronSequence Analysis
    Metal bindingi222 – 2221IronSequence Analysis
    Metal bindingi225 – 2251IronSequence Analysis
    Metal bindingi274 – 2741IronSequence Analysis
    Metal bindingi324 – 3241IronSequence Analysis
    Metal bindingi327 – 3271IronSequence Analysis

    GO - Molecular functioni

    1. alternative oxidase activity Source: TAIR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular respiration Source: TAIR
    2. mitochondria-nucleus signaling pathway Source: TAIR
    3. response to cold Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:AT3G22370-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinol oxidase 1a, mitochondrial (EC:1.10.3.11)
    Alternative name(s):
    Alternative oxidase 1a
    Gene namesi
    Name:AOX1A
    Synonyms:AOX1, HSR3
    Ordered Locus Names:At3g22370
    ORF Names:MCB17.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G22370.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: TAIR
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype under normal growth conditions. Decreased operating efficiency of photosystem II and an enhanced activity of cyclic electron transport around photosystem I. Altered photosynthetic carbon metabolism when grown under high CO2 concentrations.4 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi127 – 1271C → A, L or Q: Loss of activity and stimulation by pyruvate. 3 Publications
    Mutagenesisi127 – 1271C → E, D, R or K: Active enzyme insensitive to stimulation by pyruvate. 3 Publications
    Mutagenesisi127 – 1271C → S: Loss of oxidative inactivation and stimulation by pyruvate, but can be activated by succinate. 3 Publications
    Mutagenesisi177 – 1771C → A: No effect on stimulation by pyruvate. 1 Publication
    Mutagenesisi264 – 2641F → L: Increased resistance to a substrate-analog inhibitor. 1 Publication
    Mutagenesisi268 – 2681M → I or V: Increased resistance to a substrate-analog inhibitor. 1 Publication
    Mutagenesisi352 – 3521G → E: Increased resistance to a substrate-analog inhibitor. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6262MitochondrionSequence AnalysisAdd
    BLAST
    Chaini63 – 354292Ubiquinol oxidase 1a, mitochondrialPRO_0000001731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi127 – 127Interchain1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ39219.
    PRIDEiQ39219.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, cotyledons, leaves and flowers. High expression in sepals.3 Publications

    Developmental stagei

    Expressed throughout development. Low expression during 48 hours after imbibition and then increases.2 Publications

    Inductioni

    Up-regulated by antimycin A, low-nitrogen and salt stresses, high light, H2O2, ethylene, paraquat, rotenone, salicylic acid, malonate,erythromycin and cold treatments.10 Publications

    Gene expression databases

    GenevestigatoriQ39219.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Protein-protein interaction databases

    IntActiQ39219. 1 interaction.
    STRINGi3702.AT3G22370.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39219.
    SMRiQ39219. Positions 145-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alternative oxidase family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80852.
    HOGENOMiHOG000178442.
    InParanoidiQ39219.
    KOiK17893.
    OMAiTEWKWNC.
    PhylomeDBiQ39219.

    Family and domain databases

    InterProiIPR002680. AOX.
    [Graphical view]
    PfamiPF01786. AOX. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005229. AOX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q39219-1 [UniParc]FASTAAdd to Basket

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    MMITRGGAKA AKSLLVAAGP RLFSTVRTVS SHEALSASHI LKPGVTSAWI    50
    WTRAPTIGGM RFASTITLGE KTPMKEEDAN QKKTENESTG GDAAGGNNKG 100
    DKGIASYWGV EPNKITKEDG SEWKWNCFRP WETYKADITI DLKKHHVPTT 150
    FLDRIAYWTV KSLRWPTDLF FQRRYGCRAM MLETVAAVPG MVGGMLLHCK 200
    SLRRFEQSGG WIKALLEEAE NERMHLMTFM EVAKPKWYER ALVITVQGVF 250
    FNAYFLGYLI SPKFAHRMVG YLEEEAIHSY TEFLKELDKG NIENVPAPAI 300
    AIDYWRLPAD ATLRDVVMVV RADEAHHRDV NHFASDIHYQ GRELKEAPAP 350
    IGYH 354
    Length:354
    Mass (Da):39,980
    Last modified:December 15, 1998 - v2
    Checksum:i6DA19881E8BC9382
    GO

    Sequence cautioni

    The sequence CAA10364.1 differs from that shown. Reason: Frameshift at position 6.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371A → R in CAA10364. (PubMed:10518009)Curated
    Sequence conflicti50 – 512IW → MD in AAA32870. (PubMed:1438286)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89875 Genomic DNA. Translation: BAA22625.1.
    AJ131392 mRNA. Translation: CAA10364.1. Frameshift.
    AB022215 Genomic DNA. Translation: BAB01775.1.
    CP002686 Genomic DNA. Translation: AEE76627.1.
    AF370166 mRNA. Translation: AAK43981.1.
    AY059128 mRNA. Translation: AAL15234.1.
    M96417 mRNA. Translation: AAA32870.1.
    U85244 Genomic DNA. Translation: AAB49302.1.
    PIRiA46364.
    T51615.
    RefSeqiNP_188876.1. NM_113135.3.
    UniGeneiAt.23475.

    Genome annotation databases

    EnsemblPlantsiAT3G22370.1; AT3G22370.1; AT3G22370.
    GeneIDi821806.
    KEGGiath:AT3G22370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89875 Genomic DNA. Translation: BAA22625.1 .
    AJ131392 mRNA. Translation: CAA10364.1 . Frameshift.
    AB022215 Genomic DNA. Translation: BAB01775.1 .
    CP002686 Genomic DNA. Translation: AEE76627.1 .
    AF370166 mRNA. Translation: AAK43981.1 .
    AY059128 mRNA. Translation: AAL15234.1 .
    M96417 mRNA. Translation: AAA32870.1 .
    U85244 Genomic DNA. Translation: AAB49302.1 .
    PIRi A46364.
    T51615.
    RefSeqi NP_188876.1. NM_113135.3.
    UniGenei At.23475.

    3D structure databases

    ProteinModelPortali Q39219.
    SMRi Q39219. Positions 145-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q39219. 1 interaction.
    STRINGi 3702.AT3G22370.1-P.

    Proteomic databases

    PaxDbi Q39219.
    PRIDEi Q39219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G22370.1 ; AT3G22370.1 ; AT3G22370 .
    GeneIDi 821806.
    KEGGi ath:AT3G22370.

    Organism-specific databases

    GeneFarmi 1749. 131.
    TAIRi AT3G22370.

    Phylogenomic databases

    eggNOGi NOG80852.
    HOGENOMi HOG000178442.
    InParanoidi Q39219.
    KOi K17893.
    OMAi TEWKWNC.
    PhylomeDBi Q39219.

    Enzyme and pathway databases

    BioCyci MetaCyc:AT3G22370-MONOMER.

    Gene expression databases

    Genevestigatori Q39219.

    Family and domain databases

    InterProi IPR002680. AOX.
    [Graphical view ]
    Pfami PF01786. AOX. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005229. AOX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the gene family for alternative oxidase from Arabidopsis thaliana."
      Saisho D., Nambara E., Naito S., Tsutsumi N., Hirai A., Nakazono M.
      Plant Mol. Biol. 35:585-596(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION BY ANTIMYCIN A, TISSUE SPECIFICITY.
      Strain: cv. Columbia.
      Tissue: Leaf and Stem.
    2. "Identification of new early markers of the hypersensitive response in Arabidopsis thaliana."
      Lacomme C.J., Roby D.
      FEBS Lett. 459:149-153(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Arabidopsis alternative oxidase sustains Escherichia coli respiration."
      Kumar A.M., Soell D.
      Proc. Natl. Acad. Sci. U.S.A. 89:10842-10846(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-354, FUNCTION.
    7. Johnson Potter F., Wiskich J.T.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-354.
    8. "The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center."
      Siedow J.N., Umbach A.L., Moore A.L.
      FEBS Lett. 362:10-14(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: IRON-BINDING SITES, COFACTOR.
    9. "Isolation of mutants of the Arabidopsis thaliana alternative oxidase (ubiquinol:oxygen oxidoreductase) resistant to salicylhydroxamic acid."
      Berthold D.A.
      Biochim. Biophys. Acta 1364:73-83(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF PHE-264; MET-268 AND GLY-352.
    10. "Regulation of the cyanide-resistant alternative oxidase of plant mitochondria. Identification of the cysteine residue involved in alpha-keto acid stimulation and intersubunit disulfide bond formation."
      Rhoads D.M., Umbach A.L., Sweet C.R., Lennon A.M., Rauch G.S., Siedow J.N.
      J. Biol. Chem. 273:30750-30756(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF CYS-127 AND CYS-177, SUBUNIT, DISULFIDE BOND, ENZYME REGULATION.
    11. "A revised model of the active site of alternative oxidase."
      Andersson M.E., Nordlund P.
      FEBS Lett. 449:17-22(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IRON-BINDING SITES, COFACTOR.
    12. "A single amino acid change in the plant alternative oxidase alters the specificity of organic acid activation."
      Djajanegara I., Holtzapffel R., Finnegan P.M., Hoefnagel M.H., Berthold D.A., Wiskich J.T., Day D.A.
      FEBS Lett. 454:220-224(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF CYS-127, ENZYME REGULATION.
    13. "New insight into the structure and function of the alternative oxidase."
      Berthold D.A., Andersson M.E., Nordlund P.
      Biochim. Biophys. Acta 1460:241-254(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IRON-BINDING SITES, COFACTOR.
    14. "The gene for alternative oxidase-2 (AOX2) from Arabidopsis thaliana consists of five exons unlike other AOX genes and is transcribed at an early stage during germination."
      Saisho D., Nakazono M., Lee K.-H., Tsutsumi N., Akita S., Hirai A.
      Genes Genet. Syst. 76:89-97(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, INDUCTION BY ANTIMYCIN A.
      Strain: cv. Columbia GL1.
    15. "Activation of the plant mitochondrial alternative oxidase: insights from site-directed mutagenesis."
      Umbach A.L., Gonzalez-Meler M.A., Sweet C.R., Siedow J.N.
      Biochim. Biophys. Acta 1554:118-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF CYS-127, INDUCTION BY GLYOXLATE.
    16. "EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center."
      Berthold D.A., Voevodskaya N., Stenmark P., Graslund A., Nordlund P.
      J. Biol. Chem. 277:43608-43614(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: EPR SPECTROSCOPY.
    17. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.
    18. "Stress-induced co-expression of alternative respiratory chain components in Arabidopsis thaliana."
      Clifton R., Lister R., Parker K.L., Sappl P.G., Elhafez D., Millar A.H., Day D.A., Whelan J.
      Plant Mol. Biol. 58:193-212(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY ABIOTIC STRESSES.
    19. "The alternative oxidase of plant mitochondria is involved in the acclimation of shoot growth at low temperature. A study of Arabidopsis AOX1a transgenic plants."
      Fiorani F., Umbach A.L., Siedow J.N.
      Plant Physiol. 139:1795-1805(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "Alternative oxidases in Arabidopsis: a comparative analysis of differential expression in the gene family provides new insights into function of non-phosphorylating bypasses."
      Clifton R., Millar A.H., Whelan J.
      Biochim. Biophys. Acta 1757:730-741(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    21. "Characterization of mitochondrial alternative NAD(P)H dehydrogenases in Arabidopsis: intraorganelle location and expression."
      Elhafez D., Murcha M.W., Clifton R., Soole K.L., Day D.A., Whelan J.
      Plant Cell Physiol. 47:43-54(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    22. "Alternative oxidase involvement in cold stress response of Arabidopsis thaliana fad2 and FAD3+ cell suspensions altered in membrane lipid composition."
      Matos A.R., Hourton-Cabassa C., Cicek D., Reze N., Arrabaca J.D., Zachowski A., Moreau F.
      Plant Cell Physiol. 48:856-865(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY COLD.
    23. "Induction of the AOX1D isoform of alternative oxidase in A. thaliana T-DNA insertion lines lacking isoform AOX1A is insufficient to optimize photosynthesis when treated with antimycin A."
      Strodtkoetter I., Padmasree K., Dinakar C., Speth B., Niazi P.S., Wojtera J., Voss I., Do P.T., Nunes-Nesi A., Fernie A.R., Linke V., Raghavendra A.S., Scheibe R.
      Mol. Plant 2:284-297(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    24. "Differential gene expression profiles of the mitochondrial respiratory components in illuminated Arabidopsis leaves."
      Yoshida K., Noguchi K.
      Plant Cell Physiol. 50:1449-1462(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY HIGH LIGHT.
    25. "Effects of AOX1a deficiency on plant growth, gene expression of respiratory components and metabolic profile under low-nitrogen stress in Arabidopsis thaliana."
      Watanabe C.K., Hachiya T., Takahara K., Kawai-Yamada M., Uchimiya H., Uesono Y., Terashima I., Noguchi K.
      Plant Cell Physiol. 51:810-822(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY LOW-NITROGEN STRESS, DISRUPTION PHENOTYPE.
    26. "Involvement of ethylene and hydrogen peroxide in induction of alternative respiratory pathway in salt-treated Arabidopsis calluses."
      Wang H., Liang X., Huang J., Zhang D., Lu H., Liu Z., Bi Y.
      Plant Cell Physiol. 51:1754-1765(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY SALT STRESS; H(2)O(2) AND ETHYLENE.
    27. "Physiological impact of mitochondrial alternative oxidase on photosynthesis and growth in Arabidopsis thaliana."
      Yoshida K., Watanabe C.K., Terashima I., Noguchi K.
      Plant Cell Environ. 34:1890-1899(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    28. "Involvement of hydrogen peroxide, calcium, and ethylene in the induction of the alternative pathway in chilling-stressed Arabidopsis callus."
      Wang H., Huang J., Liang X., Bi Y.
      Planta 235:53-67(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY COLD AND ETHYLENE.
    29. "The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO2 in Arabidopsis thaliana."
      Gandin A., Duffes C., Day D.A., Cousins A.B.
      Plant Cell Physiol. 53:1627-1637(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiAOX1A_ARATH
    AccessioniPrimary (citable) accession number: Q39219
    Secondary accession number(s): O23914, P93734, Q9ZRT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Cys-127 is involved in the sulfhydryl/disulfide regulation system, but is not required for subunit dimerization. Presence of a positive charge at this residue 127 confers activity while an uncharged substitution creates an inactive enzyme (PubMed:9804851, PubMed:12034477).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3