Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DEAD-box ATP-dependent RNA helicase 7

Gene

RH7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 147ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • DEAD/H-box RNA helicase binding Source: TAIR
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • RNA metabolic process Source: TAIR
  • RNA secondary structure unwinding Source: GO_Central

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
DEAD-box ATP-dependent RNA helicase 7 (EC:3.6.4.13)
Gene namesi
Name:RH7
Synonyms:PRH75
Ordered Locus Names:At5g62190
ORF Names:MMI9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G62190
TAIRilocus:2167903 AT5G62190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002391481 – 671DEAD-box ATP-dependent RNA helicase 7Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ39189
PRIDEiQ39189

PTM databases

iPTMnetiQ39189

Expressioni

Gene expression databases

ExpressionAtlasiQ39189 baseline and differential
GenevisibleiQ39189 AT

Interactioni

GO - Molecular functioni

  • DEAD/H-box RNA helicase binding Source: TAIR

Protein-protein interaction databases

BioGridi21584, 4 interactors
IntActiQ39189, 2 interactors
STRINGi3702.AT5G62190.1

Structurei

3D structure databases

ProteinModelPortaliQ39189
SMRiQ39189
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 309Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST183
Domaini339 – 479Helicase C-terminalPROSITE-ProRule annotationAdd BLAST141

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 124Q motifAdd BLAST29
Motifi255 – 258DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi637 – 668Gly-richAdd BLAST32

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0331 Eukaryota
COG0513 LUCA
HOGENOMiHOG000268805
InParanoidiQ39189
KOiK16911
OMAiRFRGQRE
OrthoDBiEOG0936065X
PhylomeDBiQ39189

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR012562 GUCT
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR035979 RBD_domain_sf
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF08152 GUCT, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q39189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLMLSDKK EEKKMKKKMA LDTPELDSKK GKKEQKLKLS DSDEEESEKK
60 70 80 90 100
KSKKKDKKRK ASEEEDEVKS DSSSEKKKSS KKVKLGVEDV EVDNPNAVSK
110 120 130 140 150
FRISAPLREK LKANGIEALF PIQASTFDMV LDGADLVGRA RTGQGKTLAF
160 170 180 190 200
VLPILESLVN GPAKSKRKMG YGRSPSVLVL LPTRELAKQV AADFDAYGGS
210 220 230 240 250
LGLSSCCLYG GDSYPVQEGK LKRGVDIVVG TPGRIKDHIE RQNLDFSYLQ
260 270 280 290 300
FRVLDEADEM LRMGFVEDVE LILGKVEDST KVQTLLFSAT LPSWVKNISN
310 320 330 340 350
RFLKRDQKTI DLVGNDKMKA SNSVRHIAIP CNKAAMARLI PDIISCYSSG
360 370 380 390 400
GQTIIFAETK VQVSELSGLL DGSRALHGEI PQSQREVTLA GFRNGKFATL
410 420 430 440 450
VATNVAARGL DINDVQLIIQ CEPPREVEAY IHRSGRTGRA GNTGVAVTLY
460 470 480 490 500
DSRKSSVSRI EKEAGIKFEH LAAPQPDEIA RSGGMEAAEK VKQVCDSVVP
510 520 530 540 550
AFLEAAKELL ETSGLSAEVL LAKALAKTAG FTEIKKRSLL TSMENYVTLH
560 570 580 590 600
LEAGKPIYSP SFVYGLLRRV LPDDKVEMIE GLSLTADKTG AVFDVKQSDL
610 620 630 640 650
DLFIAGAQKS AGSMSLEVVK VMPKLQEREP LPQKRFGGGG RGNRFGGGGG
660 670
NRFGGGGGRG RGGSGGRGQR Y
Length:671
Mass (Da):72,891
Last modified:May 30, 2006 - v2
Checksum:iFBFD888C79F7E35C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104S → P in AAK62631 (PubMed:10718197).Curated1
Sequence conflicti196A → E in AAK62631 (PubMed:10718197).Curated1
Sequence conflicti214Y → I in CAA68194 (PubMed:9121476).Curated1
Sequence conflicti249 – 250LQ → FK in CAA68194 (PubMed:9121476).Curated2
Sequence conflicti446A → P in CAA68194 (PubMed:9121476).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99938 mRNA Translation: CAA68194.1
AB019235 Genomic DNA Translation: BAA97183.1
CP002688 Genomic DNA Translation: AED97579.1
AY039576 mRNA Translation: AAK62631.1
AY056137 mRNA Translation: AAL07216.1
BT008581 mRNA Translation: AAP40408.1
RefSeqiNP_201025.1, NM_125613.3
UniGeneiAt.22598

Genome annotation databases

EnsemblPlantsiAT5G62190.1; AT5G62190.1; AT5G62190
GeneIDi836340
GrameneiAT5G62190.1; AT5G62190.1; AT5G62190
KEGGiath:AT5G62190

Similar proteinsi

Entry informationi

Entry nameiRH7_ARATH
AccessioniPrimary (citable) accession number: Q39189
Secondary accession number(s): Q94BX7, Q9LVB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health