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Protein

Defensin-like protein 2

Gene

PDF2.2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Confers broad-spectrum resistance to pathogens.

GO - Biological processi

  • defense response Source: TAIR
  • defense response to fungus Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Fungicide

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like protein 2
Alternative name(s):
Low-molecular-weight cysteine-rich protein 69
Short name:
Protein LCR69
Plant defensin 2.2
Gene namesi
Name:PDF2.2
Synonyms:LCR69
Ordered Locus Names:At2g02100
ORF Names:F5O4.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G02100.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • extracellular region Source: UniProtKB-SubCell
  • plant-type cell wall Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 7747Defensin-like protein 2PRO_0000007024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 77By similarity
Disulfide bondi44 ↔ 64By similarity
Disulfide bondi50 ↔ 71By similarity
Disulfide bondi54 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ39182.
PRIDEiQ39182.

Expressioni

Tissue specificityi

Broadly expressed.2 Publications

Gene expression databases

GenevisibleiQ39182. AT.

Interactioni

Protein-protein interaction databases

BioGridi144. 1 interaction.
IntActiQ39182. 1 interaction.
STRINGi3702.AT2G02100.1.

Structurei

3D structure databases

ProteinModelPortaliQ39182.
SMRiQ39182. Positions 31-77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DEFL family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2FQ. Eukaryota.
ENOG410YXD4. LUCA.
HOGENOMiHOG000238637.
InParanoidiQ39182.
OMAiRDSNCAT.
PhylomeDBiQ39182.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR008177. G_Purothionin.
IPR008176. Gamma-thionin.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PRINTSiPR00288. PUROTHIONIN.
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS00940. GAMMA_THIONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSMRLISA VLIMFMIFVA TGMGPVTVEA RTCESQSHRF KGTCVSASNC
60 70
ANVCHNEGFV GGNCRGFRRR CFCTRHC
Length:77
Mass (Da):8,524
Last modified:November 1, 1996 - v1
Checksum:iEC04E660C3610965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY803259 mRNA. Translation: AAX39300.1.
AY803262 mRNA. Translation: AAX39303.1.
X69139 mRNA. Translation: CAA48892.1.
AC005936 Genomic DNA. Translation: AAC97223.1.
CP002685 Genomic DNA. Translation: AEC05546.1.
AF370355 mRNA. Translation: AAK44170.1.
Z18455 mRNA. Translation: CAA79189.1.
PIRiS30578.
RefSeqiNP_178319.1. NM_126271.2.
UniGeneiAt.24172.

Genome annotation databases

EnsemblPlantsiAT2G02100.1; AT2G02100.1; AT2G02100.
GeneIDi814741.
GrameneiAT2G02100.1; AT2G02100.1; AT2G02100.
KEGGiath:AT2G02100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY803259 mRNA. Translation: AAX39300.1.
AY803262 mRNA. Translation: AAX39303.1.
X69139 mRNA. Translation: CAA48892.1.
AC005936 Genomic DNA. Translation: AAC97223.1.
CP002685 Genomic DNA. Translation: AEC05546.1.
AF370355 mRNA. Translation: AAK44170.1.
Z18455 mRNA. Translation: CAA79189.1.
PIRiS30578.
RefSeqiNP_178319.1. NM_126271.2.
UniGeneiAt.24172.

3D structure databases

ProteinModelPortaliQ39182.
SMRiQ39182. Positions 31-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi144. 1 interaction.
IntActiQ39182. 1 interaction.
STRINGi3702.AT2G02100.1.

Proteomic databases

PaxDbiQ39182.
PRIDEiQ39182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G02100.1; AT2G02100.1; AT2G02100.
GeneIDi814741.
GrameneiAT2G02100.1; AT2G02100.1; AT2G02100.
KEGGiath:AT2G02100.

Organism-specific databases

TAIRiAT2G02100.

Phylogenomic databases

eggNOGiENOG410J2FQ. Eukaryota.
ENOG410YXD4. LUCA.
HOGENOMiHOG000238637.
InParanoidiQ39182.
OMAiRDSNCAT.
PhylomeDBiQ39182.

Miscellaneous databases

PROiQ39182.

Gene expression databases

GenevisibleiQ39182. AT.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR008177. G_Purothionin.
IPR008176. Gamma-thionin.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PRINTSiPR00288. PUROTHIONIN.
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS00940. GAMMA_THIONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome organization of more than 300 defensin-like genes in Arabidopsis."
    Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.
    Plant Physiol. 138:600-610(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY.
  2. "Isolation and expression of a cDNA encoding protease inhibitor precursor."
    Yu D.-Y., Quigley F., Mache R.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. C24.
    Tissue: Flower bud.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-75.
    Strain: cv. C24.
    Tissue: Flower bud.
  7. "Tissue-specific expression of plant defensin genes PDF2.1 and PDF2.2 in Arabidopsis thaliana."
    Thomma B.P.H.J., Broekaert W.F.
    Plant Physiol. Biochem. 36:533-537(1998)
    Cited for: TISSUE SPECIFICITY.
  8. "Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response."
    Vanoosthuyse V., Miege C., Dumas C., Cock J.M.
    Plant Mol. Biol. 46:17-34(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  9. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiDEF02_ARATH
AccessioniPrimary (citable) accession number: Q39182
Secondary accession number(s): Q42011, Q4VP00, Q4VP03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Was initially thought (Ref. 2) to be a protease inhibitor.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.