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Reviewed, UniProtKB/Swiss-Prot Q39173 (P2_ARATH)

Last modified February 9, 2010. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable NADP-dependent oxidoreductase P2
    EC=1.3.1.74
Gene names
Name: P2
Ordered Locus Names: At5g16990
ORF Names: F2K13_140
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeArabidopsis

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May play a distinct role in plant antioxidant defense and is possibly involved in NAD(P)/NAD(P)h homeostasis.

Catalytic activity

n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H.

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to oxidative stress Ref.1

Inferred from expression pattern. Source: TAIR

   Cellular componentplasma membrane

Inferred from direct assay. Source: TAIR

   Molecular function2-alkenal reductase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Probable NADP-dependent oxidoreductase P2
PRO_0000218074

Experimental info

Sequence conflict151Missing in CAA89262. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q39173-1 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 491698EF58BA82DA

FASTA34337,989
        10         20         30         40         50         60 
MTTNKQVIFK DHVSGFPKES DFNFTTTTVE LRVPEGSKSV LVKNLYLSCD PYMRSRMGKP 

        70         80         90        100        110        120 
DPSSALAQAY APGKPIYGYG VSRVIESGHP DYKKGDLLWG IVGWEEYSVI TPMAHMHFKI 

       130        140        150        160        170        180 
QHTDVPLSYY TGLLGMPGMT AYAGFYEVCS PKKGETVYVS AASGAVGQLV GQFAKMMGCY 

       190        200        210        220        230        240 
VVGSAGSKEK VDLLKTKFGF DDAFNYKEES DLSAALKRCF PKGIDMYFEN VGGKMLDAVL 

       250        260        270        280        290        300 
LNMNPHGRIA VCGMISQYNL ENQEGVHNLS NIIYKRIRIQ GFVVADFYDK YPKFLELVLP 

       310        320        330        340 
RIKEGKITYV EDVADGLEKA PEALVGLFHG KNVGKQVVVI ARE 

« Hide

References

« Hide 'large scale' references
[1]"Arabidopsis thaliana NADPH oxidoreductase homologs confer tolerance of yeasts toward the thiol-oxidizing drug diamide."
Babiychuk E., Kushnir S., Belles-Boix E., van Montagu M., Inze D.
J. Biol. Chem. 270:26224-26231(1995) [PubMed: 7592828] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. expand/collapse author list , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
Nature 408:823-826(2000) [PubMed: 11130714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49268 mRNA. Translation: CAA89262.1.
AL391141 Genomic DNA. Translation: CAC01712.1.
AY091320 mRNA. Translation: AAM14259.1.
AY065253 mRNA. Translation: AAL38729.1.
IPIIPI00517835.
PIRS57612.
T51554.
RefSeqNP_197201.1.
UniGeneAt.22439

3D structure databases

SMRQ39173. Positions 3-343.
ModBaseSearch...

Proteomic databases

PRIDEQ39173.

Genome annotation databases

GeneID831562.
GenomeReviewsGene locus AT5G16990 in contig BA000015_GR.
KEGGath:AT5G16990.
NMPDRfig|3702.1.peg.23861.

Organism-specific databases

TAIRAt5g16990.

Phylogenomic databases

eggNOGKOG1196.
HOGENOMHBG753318.
InParanoidQ39173.
OMAHEHRTIG.
PhylomeDBQ39173.

Enzyme and pathway databases

BRENDA1.3.1.74. 302.

Gene expression databases

ArrayExpressQ39173.
GenevestigatorQ39173.
GermOnlineAT5G16990. Arabidopsis thaliana.

Family and domain databases

InterProIPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2_ARATH
AccessionPrimary (citable) accession number: Q39173
Secondary accession number(s): Q9LFK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: February 9, 2010
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents