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Protein

Myosin-5

Gene

XI-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Contributes to the trafficking of Golgi stacks, mitochondria and peroxisomes. Required for development of pavement cells, trichomes, and stigmatic papillae.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi153 – 160ATPSequence analysis8
Nucleotide bindingi206 – 214ATPSequence analysis9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • motor activity Source: TAIR

GO - Biological processi

  • actin filament-based movement Source: TAIR
  • cell division Source: TAIR
  • cell growth Source: TAIR
  • fruit development Source: TAIR
  • Golgi localization Source: TAIR
  • gynoecium development Source: TAIR
  • leaf pavement cell development Source: TAIR
  • mitochondrion localization Source: TAIR
  • peroxisome localization Source: TAIR
  • post-embryonic development Source: TAIR
  • trichome morphogenesis Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-5
Alternative name(s):
AtMYA1
Gene namesi
Name:XI-1
Synonyms:MYA1
Ordered Locus Names:At1g17580
ORF Names:F1L3.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17580.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50001474781 – 1520Myosin-5Add BLAST1520

Proteomic databases

PaxDbiQ39160.

PTM databases

iPTMnetiQ39160.

Expressioni

Gene expression databases

GenevisibleiQ39160. AT.

Interactioni

Subunit structurei

Homodimer. Interacts with MYOB1 and MYOB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2010084,EBI-2010084

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi23573. 1 interactor.
STRINGi3702.AT1G17580.1.

Structurei

3D structure databases

ProteinModelPortaliQ39160.
SMRiQ39160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 729Myosin motorAdd BLAST671
Domaini732 – 761IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini755 – 784IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini780 – 809IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini803 – 832IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini828 – 857IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini851 – 880IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1148 – 1463DilutePROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni492 – 526Actin-bindingSequence analysisAdd BLAST35
Regioni528 – 551Actin-bindingSequence analysisAdd BLAST24
Regioni586 – 610Actin-bindingSequence analysisAdd BLAST25
Regioni610 – 632Actin-bindingBy similarityAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili881 – 1047Sequence analysisAdd BLAST167

Domaini

IQ domain mediates interaction with calmodulin.By similarity
The tail domain is a globular cargo-binding domain.By similarity

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000029608.
InParanoidiQ39160.
OMAiMFLLERS.
OrthoDBiEOG093600DR.
PhylomeDBiQ39160.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 5 hits.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVIIVGS HVWVEDPHLA WIDGEVTRID GINVHVKTKK GKTVVTNVYF
60 70 80 90 100
PKDTEAPSGG VDDMTKLSYL HEPGVLRNLE TRYELNEIYT YTGNILIAVN
110 120 130 140 150
PFQRLPHIYE TDMMEQYKGI ALGELSPHVF AIGDAAYRAM INEGKNNSIL
160 170 180 190 200
VSGESGAGKT ETTKMLMRYL AFLGGRSGVE GRTVEQQVLE SNPVLEAFGN
210 220 230 240 250
AKTLRNNNSS RFGKFVEIQF DKNGRISGAA IRTYLLERSR VCQISDPERN
260 270 280 290 300
YHCFYLLCAA PPEDIKKYKL ENPHKFHYLN QSSCYKLDGV DDASEYLETR
310 320 330 340 350
RAMDVVGISN EEQEAIFRVV AAILHLGNID FGKGEEIDSS VIKDKDSRSH
360 370 380 390 400
LNMAAELLMC NAQSLEDALI RRVMVTPEEI ITRTLDPDNA IASRDTLAKT
410 420 430 440 450
IYSHLFDWIV NKINTSIGQD PRSKSIIGVL DIYGFESFKC NSFEQFCINF
460 470 480 490 500
TNEKLQQHFN QHVFKMEQEE YTKEEIAWSY IEFIDNQDVL ELIEKKPGGI
510 520 530 540 550
ISLLDEACMF PKSTHETFSQ KLFQTFKEHE RFAKPKLSRT DFTISHYAGE
560 570 580 590 600
VTYQSNHFID KNKDYIVAEH QALFTASNCK FVAGLFHALH EDSSRSSKFS
610 620 630 640 650
SIGSRFKQQL HSLMESLNGT EPHYIRCIKP NNVLKPGIFE NFNVIHQLRC
660 670 680 690 700
GGVLEAIRIS CAGYPTRLAF YDFLDRFGLL APEVLEGNYD DKVACQMILD
710 720 730 740 750
KKSLTDYQIG KTKIFLRAGQ MAELDARRAE VLGNAARVIQ RQFRTCMARK
760 770 780 790 800
NYRSIRNAAI VLQSFLRGEI ARAVHKKLRI EAAALRVQKN FRRYVDRKSF
810 820 830 840 850
VTTRSSTIVL QTGLRAMIAR SEFRLRRQRK AAIVLQAHWR GRQAFSYYTR
860 870 880 890 900
LQKAAIVTQC AWRCRLARRE LRMLKMAARD TGALKDAKNK LEQRVEELSL
910 920 930 940 950
RLHLEKRLRT DLEEAKVQEV AKLQEALHTM RLQLKETTAM VVKEQEAARV
960 970 980 990 1000
AIEEASSVNK EPVVVEDTEK IDSLSNEIDR LKGLLSSETH KADEAQHAYQ
1010 1020 1030 1040 1050
SALVQNEELC KKLEEAGRKI DQLQDSVQRF QEKVFSLESE NKVLRQQTLT
1060 1070 1080 1090 1100
ISPTTRALAL RPKTTIIQRT PEKDTFSNGE TTQLQEPETE DRPQKSLNQK
1110 1120 1130 1140 1150
QQENQELLLK SISEDIGFSE GKPVAACLIY KCLIHWRSFE VERTSIFNRI
1160 1170 1180 1190 1200
IETIASAIEM QENSDVLCYW LSNSATLLMF LQRTLKAGAT GSITTPRRRG
1210 1220 1230 1240 1250
MPSSLFGRVS QSFRGSPQSA GFPFMTGRAI GGGLDELRQV EAKYPALLFK
1260 1270 1280 1290 1300
QQLTAFLEKI YGMIRDKMKK EISPLLASCI QVPRTPRSGL VKGRSQNTQN
1310 1320 1330 1340 1350
NVVAPKPMIA HWQNIVTCLN GHLRTMRANY VPSLLISKVF GQIFSFINVQ
1360 1370 1380 1390 1400
LFNSLLLRRE CCSFSNGEYV KTGLAELEKW CHDATEEFVG SAWDELKHIR
1410 1420 1430 1440 1450
QAVGFLVIHQ KPKKSLKEIT TELCPVLSIQ QLYRISTMYW DDKYGTHSVS
1460 1470 1480 1490 1500
TEVIATMRAE VSDVSKSAIS NSFLLDDDSS IPFSLDDISK SMQNVEVAEV
1510 1520
DPPPLIRQNS NFMFLLERSD
Length:1,520
Mass (Da):172,908
Last modified:November 1, 1996 - v1
Checksum:i3A07CCDF9088C344
GO

Sequence cautioni

The sequence AAF79470 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28389 mRNA. Translation: CAA82234.1.
AC022492 Genomic DNA. Translation: AAF79470.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29607.1.
PIRiS46444.
RefSeqiNP_173201.2. NM_101620.3.
UniGeneiAt.21949.

Genome annotation databases

EnsemblPlantsiAT1G17580.1; AT1G17580.1; AT1G17580.
GeneIDi838333.
GrameneiAT1G17580.1; AT1G17580.1; AT1G17580.
KEGGiath:AT1G17580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28389 mRNA. Translation: CAA82234.1.
AC022492 Genomic DNA. Translation: AAF79470.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29607.1.
PIRiS46444.
RefSeqiNP_173201.2. NM_101620.3.
UniGeneiAt.21949.

3D structure databases

ProteinModelPortaliQ39160.
SMRiQ39160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23573. 1 interactor.
STRINGi3702.AT1G17580.1.

PTM databases

iPTMnetiQ39160.

Proteomic databases

PaxDbiQ39160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17580.1; AT1G17580.1; AT1G17580.
GeneIDi838333.
GrameneiAT1G17580.1; AT1G17580.1; AT1G17580.
KEGGiath:AT1G17580.

Organism-specific databases

TAIRiAT1G17580.

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000029608.
InParanoidiQ39160.
OMAiMFLLERS.
OrthoDBiEOG093600DR.
PhylomeDBiQ39160.

Miscellaneous databases

PROiQ39160.

Gene expression databases

GenevisibleiQ39160. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 5 hits.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5_ARATH
AccessioniPrimary (citable) accession number: Q39160
Secondary accession number(s): Q9LNP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.