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Protein

Gibberellin 20 oxidase 2

Gene

GA20OX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key oxidase enzyme in the biosynthesis of gibberellin that catalyzes the conversion of GA12 and GA53 to GA9 and GA20 respectively, via a three-step oxidation at C-20 of the GA skeleton. GA53 is less effectively oxidized than GA12, and GA25 is also formed as a minor product. Involved in the promotion of the floral transition, fertility and silique elongation, but plays only a minor role in elongation of seedling organs. Acts redundantly with GA20OX1.1 Publication

Cofactori

Protein has several cofactor binding sites:

Pathwayi: gibberellin biosynthesis

This protein is involved in the pathway gibberellin biosynthesis, which is part of Plant hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gibberellin biosynthesis and in Plant hormone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi245IronPROSITE-ProRule annotation1
Metal bindingi247IronPROSITE-ProRule annotation1
Metal bindingi301IronPROSITE-ProRule annotation1
Active sitei311Sequence analysis1

GO - Molecular functioni

  • gibberellin 20-oxidase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • flower development Source: TAIR
  • gibberellic acid mediated signaling pathway Source: GO_Central
  • gibberellin biosynthetic process Source: TAIR
  • response to gibberellin Source: TAIR
  • response to karrikin Source: TAIR
  • response to red or far red light Source: TAIR
  • unidimensional cell growth Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G51810-MONOMER
MetaCyc:AT5G51810-MONOMER
BRENDAi1.14.11.12 399
UniPathwayiUPA00390

Names & Taxonomyi

Protein namesi
Recommended name:
Gibberellin 20 oxidase 2 (EC:1.14.11.-)
Alternative name(s):
GA 20-oxidase 2
Gibberellin C-20 oxidase 2
Gene namesi
Name:GA20OX2
Synonyms:20ox, At2353
Ordered Locus Names:At5g51810
ORF Names:MIO24.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G51810
TAIRilocus:2165341 AT5G51810

Pathology & Biotechi

Disruption phenotypei

Slightly smaller than the wild type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002195151 – 378Gibberellin 20 oxidase 2Add BLAST378

Proteomic databases

PaxDbiQ39111

Expressioni

Tissue specificityi

Expressed in inflorescence and developing siliques. Detected in seeds, roots, cotyledons and leaves. In seeds, specifically detected at the rim of the embryo and the outer integument.4 Publications

Developmental stagei

Expressed in developing siliques 3-13 days after pollination.1 Publication

Inductioni

Negatively controlled by the level of physiologically active gibberellin. Up-regulated by auxin, paclobutrazol, long day exposure and cold treatment.4 Publications

Gene expression databases

ExpressionAtlasiQ39111 baseline and differential
GenevisibleiQ39111 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G51810.1

Structurei

3D structure databases

ProteinModelPortaliQ39111
SMRiQ39111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 320Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0143 Eukaryota
COG3491 LUCA
HOGENOMiHOG000276735
InParanoidiQ39111
KOiK05282
OMAiSQFIWPA
OrthoDBiEOG09360BJH
PhylomeDBiQ39111

Family and domain databases

Gene3Di2.60.120.330, 1 hit
InterProiView protein in InterPro
IPR026992 DIOX_N
IPR027443 IPNS-like
IPR005123 Oxoglu/Fe-dep_dioxygenase
PfamiView protein in Pfam
PF03171 2OG-FeII_Oxy, 1 hit
PF14226 DIOX_N, 1 hit
PROSITEiView protein in PROSITE
PS51471 FE2OG_OXY, 1 hit

Sequencei

Sequence statusi: Complete.

Q39111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILCTTTSP AEKEHEPKQD LEKDQTSPLI FNPSLLNLQS QIPNQFIWPD
60 70 80 90 100
EEKPSIDIPE LNVPFIDLSS QDSTLEAPRV IAEACTKHGF FLVVNHGVSE
110 120 130 140 150
SLIADAHRLM ESFFDMPLAG KQKAQRKPGE SCGYASSFTG RFSTKLPWKE
160 170 180 190 200
TLSFQFSNDN SGSRTVQDYF SDTLGQEFEQ FGKVYQDYCE AMSSLSLKIM
210 220 230 240 250
ELLGLSLGVN RDYFRGFFEE NDSIMRLNHY PPCQTPDLTL GTGPHCDPSS
260 270 280 290 300
LTILHQDHVN GLQVFVDNQW QSIRPNPKAF VVNIGDTFMA LSNGIFKSCL
310 320 330 340 350
HRAVVNRESA RKSMAFFLCP KKDKVVKPPS DILEKMKTRK YPDFTWSMFL
360 370
EFTQKHYRAD VNTLDSFSNW VITNNNPI
Length:378
Mass (Da):42,937
Last modified:November 1, 1996 - v1
Checksum:i0B5CF4E6FDBD2B74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83380 mRNA Translation: CAA58294.1
AB010074 Genomic DNA Translation: BAB11250.1
CP002688 Genomic DNA Translation: AED96129.1
RefSeqiNP_199994.1, NM_124560.4
UniGeneiAt.28053

Genome annotation databases

EnsemblPlantsiAT5G51810.1; AT5G51810.1; AT5G51810
GeneIDi835256
GrameneiAT5G51810.1; AT5G51810.1; AT5G51810
KEGGiath:AT5G51810

Similar proteinsi

Entry informationi

Entry nameiGAOX2_ARATH
AccessioniPrimary (citable) accession number: Q39111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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