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Q39101

- FRI1_ARATH

UniProt

Q39101 - FRI1_ARATH

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Protein

Ferritin-1, chloroplastic

Gene
FER1, At5g01600, F7A7.120
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi105 – 1051Iron 1 By similarity
Metal bindingi140 – 1401Iron 1 By similarity
Metal bindingi140 – 1401Iron 2 By similarity
Metal bindingi143 – 1431Iron 1 By similarity
Metal bindingi189 – 1891Iron 2 By similarity
Metal bindingi223 – 2231Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
  3. iron ion binding Source: TAIR

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. flower development Source: TAIR
  3. iron ion homeostasis Source: TAIR
  4. iron ion transport Source: TAIR
  5. leaf development Source: TAIR
  6. photosynthesis Source: TAIR
  7. response to bacterium Source: TAIR
  8. response to cold Source: TAIR
  9. response to hydrogen peroxide Source: TAIR
  10. response to iron ion Source: TAIR
  11. response to reactive oxygen species Source: TAIR
  12. response to zinc ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1, chloroplastic (EC:1.16.3.1)
Short name:
AtFer1
Gene namesi
Name:FER1
Ordered Locus Names:At5g01600
ORF Names:F7A7.120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G01600.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast stroma Source: TAIR
  3. chloroplast thylakoid membrane Source: TAIR
  4. membrane Source: TAIR
  5. mitochondrion Source: TAIR
  6. thylakoid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4848Chloroplast By similarityAdd
BLAST
Chaini49 – 255207Ferritin-1, chloroplasticPRO_0000008854Add
BLAST

Proteomic databases

PaxDbiQ39101.
PRIDEiQ39101.

Expressioni

Inductioni

By iron overload treatment, and by H2O2.1 Publication

Gene expression databases

GenevestigatoriQ39101.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ39101.
SMRiQ39101. Positions 82-255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 241154Ferritin-like diironAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 8739Extension peptide (EP)Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223383.
InParanoidiQ39101.
KOiK00522.
OMAiASENNDP.
PhylomeDBiQ39101.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39101-1 [UniParc]FASTAAdd to Basket

« Hide

MASNALSSFT AANPALSPKP LLPHGSASPS VSLGFSRKVG GGRAVVVAAA    50
TVDTNNMPMT GVVFQPFEEV KKADLAIPIT SHASLARQRF ADASEAVINE 100
QINVEYNVSY VYHSMYAYFD RDNVAMKGLA KFFKESSEEE RGHAEKFMEY 150
QNQRGGRVKL HPIVSPISEF EHAEKGDALY AMELALSLEK LTNEKLLNVH 200
KVASENNDPQ LADFVESEFL GEQIEAIKKI SDYITQLRMI GKGHGVWHFD 250
QMLLN 255
Length:255
Mass (Da):28,178
Last modified:November 1, 1996 - v1
Checksum:iC40E89CA4548FCB0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421G → S in AAM61077. 1 Publication
Sequence conflicti67 – 671F → L in AAM61077. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94248 mRNA. Translation: CAA63932.1.
AF229850 Genomic DNA. Translation: AAF73918.1.
AL161946 Genomic DNA. Translation: CAB82276.1.
CP002688 Genomic DNA. Translation: AED90364.1.
AF326869 mRNA. Translation: AAG41451.1.
AF339691 mRNA. Translation: AAK00373.1.
AF412065 mRNA. Translation: AAL06518.1.
AY084509 mRNA. Translation: AAM61077.1.
PIRiS71880.
RefSeqiNP_195780.1. NM_120238.4.
UniGeneiAt.23533.
At.73124.
At.75488.

Genome annotation databases

EnsemblPlantsiAT5G01600.1; AT5G01600.1; AT5G01600.
GeneIDi831720.
KEGGiath:AT5G01600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94248 mRNA. Translation: CAA63932.1 .
AF229850 Genomic DNA. Translation: AAF73918.1 .
AL161946 Genomic DNA. Translation: CAB82276.1 .
CP002688 Genomic DNA. Translation: AED90364.1 .
AF326869 mRNA. Translation: AAG41451.1 .
AF339691 mRNA. Translation: AAK00373.1 .
AF412065 mRNA. Translation: AAL06518.1 .
AY084509 mRNA. Translation: AAM61077.1 .
PIRi S71880.
RefSeqi NP_195780.1. NM_120238.4.
UniGenei At.23533.
At.73124.
At.75488.

3D structure databases

ProteinModelPortali Q39101.
SMRi Q39101. Positions 82-255.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q39101.
PRIDEi Q39101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G01600.1 ; AT5G01600.1 ; AT5G01600 .
GeneIDi 831720.
KEGGi ath:AT5G01600.

Organism-specific databases

TAIRi AT5G01600.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223383.
InParanoidi Q39101.
KOi K00522.
OMAi ASENNDP.
PhylomeDBi Q39101.

Enzyme and pathway databases

BioCyci ARA:AT5G01600-MONOMER.

Gene expression databases

Genevestigatori Q39101.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a ferritin mRNA from Arabidopsis thaliana accumulated in response to iron through an oxidative pathway independent of abscisic acid."
    Gaymard F., Boucherez J., Briat J.-F.
    Biochem. J. 318:67-73(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of an iron-dependent regulatory sequence (IDRS) involved in AtFer1 and ZmFer1 plant ferritin gene transcriptional control by iron."
    Petit J.-M., van Wuytswinkel O., Briat J.-F., Lobreaux S.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Landsberg erecta.
  3. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family."
    Petit J.-M., Briat J.-F., Lobreaux S.
    Biochem. J. 359:575-582(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiFRI1_ARATH
AccessioniPrimary (citable) accession number: Q39101
Secondary accession number(s): Q8LG19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi