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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:Bcep18194_B2950
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003254911 – 553Probable malate:quinone oxidoreductaseAdd BLAST553

Structurei

3D structure databases

ProteinModelPortaliQ390Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiPOG091H0B7C.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q390Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGSAVIKT LRVILSALAL CVATSSAHAA DTKKVDVLLV GGGIMSSTLG
60 70 80 90 100
VWLHELQPDW SMTMVERLDG VALESSNGWN NAGTGHSALA ELNYTPEKAD
110 120 130 140 150
GKIDISKAIE INESFQISRQ FWAWQVKQGV LKNPHSFINS TPHMSFVWGD
160 170 180 190 200
DNVRFLKKRY EALQASPLFR GMQYSEDYDQ IKQWVPLMME GRDPKQKVAA
210 220 230 240 250
TWTPIGTDVN FGEITRQFVG YLKTQPNFTL SLSSEVREIS RNADGTWHVS
260 270 280 290 300
WVKLHSDEPA QSVDAKFVFI GAGGGALHLL QASGVPEAKD YGAFPVGGSF
310 320 330 340 350
LVTENPEVVK QHLAKAYGKA SVGSPPMSVP HLDTRIIDGK KIILFGPFAT
360 370 380 390 400
FSTKFLKNGS YFDLLKSTNT HNVAPMMRVG VDEFPLVQYL AGQLMLSDDD
410 420 430 440 450
RFNALKEYFP NAKKEDWRLW QAGQRVQIIK RDPVKGGVLK LGTEIVASQD
460 470 480 490 500
GSIAGLLGAS PGASTAAPIM LNLMKKVFKD KVATPEWQQK IRQIVPSYGT
510 520 530 540 550
KLNDSPAKVV EEWTYTSDVL QLSPPPKIDV NTPSQATGTA PARPAKASAD

MAL
Length:553
Mass (Da):60,590
Last modified:November 22, 2005 - v1
Checksum:iD38609F6EDF69809
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA. Translation: ABB13061.1.

Genome annotation databases

EnsemblBacteriaiABB13061; ABB13061; Bcep18194_B2950.
KEGGibur:Bcep18194_B2950.
PATRICifig|482957.22.peg.6772.

Similar proteinsi

Entry informationi

Entry nameiMQO_BURL3
AccessioniPrimary (citable) accession number: Q390Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families