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Q390P5

- ACDH3_BURL3

UniProt

Q390P5 - ACDH3_BURL3

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Protein

Acetaldehyde dehydrogenase 3

Gene

Bcep18194_B2960

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
Binding sitei273 – 2731NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1709NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSP269483:GHLS-6381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:Bcep18194_B2960
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002705: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Acetaldehyde dehydrogenase 3PRO_0000387640Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269483.Bcep18194_B2960.

Structurei

3D structure databases

ProteinModelPortaliQ390P5.
SMRiQ390P5. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q390P5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRKIRCALI GPGNIGTDLL AKLMRSPVLE PVWMVGIDPD SDGLKRAREL
60 70 80 90 100
GLKTTAEGVD GLLPHVQADA VQIAFDATSA YVHAENSRKL NALGVLMIDL
110 120 130 140 150
TPAAIGPYCV PPVNLMDHIG SGEMNVNMVT CGGQATIPMV RAVSRVQPVA
160 170 180 190 200
YGEIVATVSS RSVGPGTRKN IDEFTRTTAA AVAQVGGAKD GKAIIVINPA
210 220 230 240 250
DPPLIMRDTV HCLTETAPDE ARIVESVHAM IADVQRYVPG YRLVNGPVFD
260 270 280 290 300
GNRVSIYLEV EGLGDYLPKY AGNLDIMTAA AARTAEMFAE ELLAGRLALQ

PAAQAA
Length:306
Mass (Da):32,364
Last modified:November 22, 2005 - v1
Checksum:i854CD418D71933AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA. Translation: ABB13071.1.
RefSeqiWP_011356550.1. NC_007511.1.
YP_373715.1. NC_007511.1.

Genome annotation databases

EnsemblBacteriaiABB13071; ABB13071; Bcep18194_B2960.
GeneIDi3754727.
KEGGibur:Bcep18194_B2960.
PATRICi19296898. VBIBurSp120713_7808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA. Translation: ABB13071.1 .
RefSeqi WP_011356550.1. NC_007511.1.
YP_373715.1. NC_007511.1.

3D structure databases

ProteinModelPortali Q390P5.
SMRi Q390P5. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269483.Bcep18194_B2960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB13071 ; ABB13071 ; Bcep18194_B2960 .
GeneIDi 3754727.
KEGGi bur:Bcep18194_B2960.
PATRICi 19296898. VBIBurSp120713_7808.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BSP269483:GHLS-6381-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383.

Entry informationi

Entry nameiACDH3_BURL3
AccessioniPrimary (citable) accession number: Q390P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3