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Q39090 (UFO_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein UNUSUAL FLORAL ORGANS
Alternative name(s):
F-box only protein 1
Short name=AtFBX1
Gene names
Name:UFO
Synonyms:FBX1
Ordered Locus Names:At1g30950
ORF Names:F17F8.16
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes. Ref.5 Ref.6 Ref.7

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of a putative SCF (ASK/Cullin/F-box) ubiquitin ligase complex. Interacts with SKP1A/ASK1, SKP1B/ASK2 and ASK11. Ref.9 Ref.10 Ref.11

Subcellular location

Nucleus Probable.

Developmental stage

Detected early throughout the shoot apical meristem, but not in the emerging leaf primordia. Restricted later to the junction between sepal and petal primordia. Ref.6

Domain

The F-box is necessary for the interaction with ASK proteins By similarity. Ref.11

Miscellaneous

Mutations in the UFO gene result in the formation of unusual floral organs.

Sequence similarities

Contains 1 F-box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Protein UNUSUAL FLORAL ORGANS
PRO_0000119966

Regions

Domain44 – 9047F-box
Region1 – 8585Interaction with SKP1A

Experimental info

Sequence conflict441G → C in CAA61508. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q39090 [UniParc].

Last modified May 9, 2003. Version 2.
Checksum: 6E5C38B0F92AE8B7

FASTA44249,047
        10         20         30         40         50         60 
MDSTVFINNP SLTLPFSYTF TSSSNSSTTT STTTDSSSGQ WMDGRIWSKL PPPLLDRVIA 

        70         80         90        100        110        120 
FLPPPAFFRT RCVCKRFYSL LFSNTFLETY LQLLPLRHNC FLFFKHKTLK SYIYKRGGTN 

       130        140        150        160        170        180 
DDDSNKAEGF LFDPNEIRWY RLSFAYIPSG FYPSGSSGGL VSWVSEEAGL KTILLCNPLV 

       190        200        210        220        230        240 
GSVSQLPPIS RPRLFPSIGL SVTPTSIDVT VAGDDLISPY AVKNLSSESF HVDAGGFFSL 

       250        260        270        280        290        300 
WAMTSSLPRL CSLESGKMVY VQGKFYCMNY SPFSVLSYEV TGNRWIKIQA PMRRFLRSPS 

       310        320        330        340        350        360 
LLESKGRLIL VAAVEKSKLN VPKSLRLWSL QQDNATWVEI ERMPQPLYTQ FAAEEGGKGF 

       370        380        390        400        410        420 
ECVGNQEFVM IVLRGTSLQL LFDIVRKSWL WVPPCPYSGS GGGSSGGGSD GEVLQGFAYD 

       430        440 
PVLTTPVVSL LDQLTLPFPG VC 

« Hide

References

« Hide 'large scale' references
[1]"Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum."
Ingram G.C., Goodrich J., Wilkinson M.D., Simon R., Haughn G.W., Coen E.S.
Plant Cell 7:1501-1510(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: cv. Landsberg erecta.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function."
Krizek B.A., Meyerowitz E.M.
Development 122:11-22(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"A LEAFY co-regulator encoded by UNUSUAL FLORAL ORGANS."
Lee I., Wolfe D.S., Nilsson O., Weigel D.
Curr. Biol. 7:95-104(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[7]"The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem."
Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L.
Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"F-box proteins in Arabidopsis."
Xiao W., Jang J.-C.
Trends Plant Sci. 5:454-457(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[9]"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis."
Zhao D., Yu Q., Chen M., Ma H.
Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[10]"The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis."
Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.
Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2 AND ASK11.
[11]"The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis."
Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C.
Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKP1A, DOMAIN.
+Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89224 Genomic DNA. Translation: CAA61508.1.
AC000107 Genomic DNA. Translation: AAF98199.1.
CP002684 Genomic DNA. Translation: AEE31296.1.
DQ056469 mRNA. Translation: AAY78626.1.
PIRS57710.
RefSeqNP_564368.1. NM_102834.1.
UniGeneAt.51845.

3D structure databases

ProteinModelPortalQ39090.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid25217. 15 interactions.
IntActQ39090. 15 interactions.

Proteomic databases

PRIDEQ39090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G30950.1; AT1G30950.1; AT1G30950.
GeneID839982.
KEGGath:AT1G30950.

Organism-specific databases

TAIRAT1G30950.

Phylogenomic databases

eggNOGNOG303383.
HOGENOMHOG000084155.
InParanoidQ39090.
OMAVEIERMP.
PhylomeDBQ39090.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorQ39090.

Family and domain databases

InterProIPR001810. F-box_dom.
[Graphical view]
PfamPF00646. F-box. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUFO_ARATH
AccessionPrimary (citable) accession number: Q39090
Secondary accession number(s): Q4PT17, Q9FYI4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names