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Q39090

- UFO_ARATH

UniProt

Q39090 - UFO_ARATH

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Protein

Protein UNUSUAL FLORAL ORGANS

Gene

UFO

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes.By similarity3 Publications

Pathwayi

GO - Molecular functioni

  1. transcription factor binding Source: TAIR
  2. ubiquitin-protein transferase activity Source: TAIR

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. flower development Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: TAIR
  4. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: TAIR
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Flowering, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UNUSUAL FLORAL ORGANS
Alternative name(s):
F-box only protein 1
Short name:
AtFBX1
Gene namesi
Name:UFO
Synonyms:FBX1
Ordered Locus Names:At1g30950
ORF Names:F17F8.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G30950.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Protein UNUSUAL FLORAL ORGANSPRO_0000119966Add
BLAST

Proteomic databases

PRIDEiQ39090.

Expressioni

Developmental stagei

Detected early throughout the shoot apical meristem, but not in the emerging leaf primordia. Restricted later to the junction between sepal and petal primordia.1 Publication

Gene expression databases

GenevestigatoriQ39090.

Interactioni

Subunit structurei

Part of a putative SCF (ASK/Cullin/F-box) ubiquitin ligase complex. Interacts with SKP1A/ASK1, SKP1B/ASK2 and ASK11.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ASK11O494843EBI-590758,EBI-401185
LFYQ009586EBI-590758,EBI-1644366
SKP1AQ392556EBI-590758,EBI-532357
SKP1BQ9FHW75EBI-590758,EBI-604076
SRK2AP432913EBI-590758,EBI-401164

Protein-protein interaction databases

BioGridi25217. 15 interactions.
IntActiQ39090. 15 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ39090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 9047F-boxPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8585Interaction with SKP1AAdd
BLAST

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG303383.
HOGENOMiHOG000084155.
InParanoidiQ39090.
OMAiVEIERMP.
PhylomeDBiQ39090.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39090-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSTVFINNP SLTLPFSYTF TSSSNSSTTT STTTDSSSGQ WMDGRIWSKL
60 70 80 90 100
PPPLLDRVIA FLPPPAFFRT RCVCKRFYSL LFSNTFLETY LQLLPLRHNC
110 120 130 140 150
FLFFKHKTLK SYIYKRGGTN DDDSNKAEGF LFDPNEIRWY RLSFAYIPSG
160 170 180 190 200
FYPSGSSGGL VSWVSEEAGL KTILLCNPLV GSVSQLPPIS RPRLFPSIGL
210 220 230 240 250
SVTPTSIDVT VAGDDLISPY AVKNLSSESF HVDAGGFFSL WAMTSSLPRL
260 270 280 290 300
CSLESGKMVY VQGKFYCMNY SPFSVLSYEV TGNRWIKIQA PMRRFLRSPS
310 320 330 340 350
LLESKGRLIL VAAVEKSKLN VPKSLRLWSL QQDNATWVEI ERMPQPLYTQ
360 370 380 390 400
FAAEEGGKGF ECVGNQEFVM IVLRGTSLQL LFDIVRKSWL WVPPCPYSGS
410 420 430 440
GGGSSGGGSD GEVLQGFAYD PVLTTPVVSL LDQLTLPFPG VC
Length:442
Mass (Da):49,047
Last modified:May 9, 2003 - v2
Checksum:i6E5C38B0F92AE8B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441G → C in CAA61508. (PubMed:8589630)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89224 Genomic DNA. Translation: CAA61508.1.
AC000107 Genomic DNA. Translation: AAF98199.1.
CP002684 Genomic DNA. Translation: AEE31296.1.
DQ056469 mRNA. Translation: AAY78626.1.
PIRiS57710.
RefSeqiNP_564368.1. NM_102834.1.
UniGeneiAt.51845.

Genome annotation databases

EnsemblPlantsiAT1G30950.1; AT1G30950.1; AT1G30950.
GeneIDi839982.
KEGGiath:AT1G30950.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89224 Genomic DNA. Translation: CAA61508.1 .
AC000107 Genomic DNA. Translation: AAF98199.1 .
CP002684 Genomic DNA. Translation: AEE31296.1 .
DQ056469 mRNA. Translation: AAY78626.1 .
PIRi S57710.
RefSeqi NP_564368.1. NM_102834.1.
UniGenei At.51845.

3D structure databases

ProteinModelPortali Q39090.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 25217. 15 interactions.
IntActi Q39090. 15 interactions.

Proteomic databases

PRIDEi Q39090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G30950.1 ; AT1G30950.1 ; AT1G30950 .
GeneIDi 839982.
KEGGi ath:AT1G30950.

Organism-specific databases

TAIRi AT1G30950.

Phylogenomic databases

eggNOGi NOG303383.
HOGENOMi HOG000084155.
InParanoidi Q39090.
OMAi VEIERMP.
PhylomeDBi Q39090.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Gene expression databases

Genevestigatori Q39090.

Family and domain databases

InterProi IPR001810. F-box_dom.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum."
    Ingram G.C., Goodrich J., Wilkinson M.D., Simon R., Haughn G.W., Coen E.S.
    Plant Cell 7:1501-1510(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: cv. Landsberg erecta.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function."
    Krizek B.A., Meyerowitz E.M.
    Development 122:11-22(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "A LEAFY co-regulator encoded by UNUSUAL FLORAL ORGANS."
    Lee I., Wolfe D.S., Nilsson O., Weigel D.
    Curr. Biol. 7:95-104(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  7. "The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem."
    Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L.
    Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: GENE FAMILY, NOMENCLATURE.
  9. "The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis."
    Zhao D., Yu Q., Chen M., Ma H.
    Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  10. "The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis."
    Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2 AND ASK11.
  11. "The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis."
    Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKP1A, DOMAIN.

Entry informationi

Entry nameiUFO_ARATH
AccessioniPrimary (citable) accession number: Q39090
Secondary accession number(s): Q4PT17, Q9FYI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Mutations in the UFO gene result in the formation of unusual floral organs.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3