Protein UNUSUAL FLORAL ORGANS - Arabidopsis thaliana (Mouse-ear cress)

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Q39090 (UFO_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein UNUSUAL FLORAL ORGANS

Alternative name(s):
F-box only protein 1
Short name=AtFBX1

Gene names

Name:	UFO
Synonyms:	FBX1
Ordered Locus Names:	At1g30950
ORF Names:	F17F8.16

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes. Ref.5 Ref.6 Ref.7
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Part of a putative SCF (ASK/Cullin/F-box) ubiquitin ligase complex. Interacts with SKP1A/ASK1, SKP1B/ASK2 and ASK11. Ref.9 Ref.10 Ref.11
Subcellular location	Nucleus Probable.
Developmental stage	Detected early throughout the shoot apical meristem, but not in the emerging leaf primordia. Restricted later to the junction between sepal and petal primordia. Ref.6
Domain	The F-box is necessary for the interaction with ASK proteins By similarity. Ref.11
Miscellaneous	Mutations in the UFO gene result in the formation of unusual floral organs.
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Differentiation Flowering Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from genetic interaction PubMed 15047903. Source: TAIR cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW flower development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from direct assay PubMed 18287201. Source: TAIR transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ubiquitin-protein ligase activity Inferred from mutant phenotype PubMed 18287201. Source: TAIR
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
ASK11	O49484	3	EBI-590758,EBI-401185
LFY	Q00958	6	EBI-590758,EBI-1644366
SKP1A	Q39255	6	EBI-590758,EBI-532357
SKP1B	Q9FHW7	5	EBI-590758,EBI-604076
SRK2A	P43291	3	EBI-590758,EBI-401164

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 442

442

Protein UNUSUAL FLORAL ORGANS

PRO_0000119966

Regions

Domain

44 – 90

F-box

Region

1 – 85

Interaction with SKP1A

Experimental info

Sequence conflict

G → C in CAA61508. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q39090 [UniParc].

Last modified May 9, 2003. Version 2.
Checksum: 6E5C38B0F92AE8B7
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FASTA

442

49,047

        10         20         30         40         50         60 
MDSTVFINNP SLTLPFSYTF TSSSNSSTTT STTTDSSSGQ WMDGRIWSKL PPPLLDRVIA 

        70         80         90        100        110        120 
FLPPPAFFRT RCVCKRFYSL LFSNTFLETY LQLLPLRHNC FLFFKHKTLK SYIYKRGGTN 

       130        140        150        160        170        180 
DDDSNKAEGF LFDPNEIRWY RLSFAYIPSG FYPSGSSGGL VSWVSEEAGL KTILLCNPLV 

       190        200        210        220        230        240 
GSVSQLPPIS RPRLFPSIGL SVTPTSIDVT VAGDDLISPY AVKNLSSESF HVDAGGFFSL 

       250        260        270        280        290        300 
WAMTSSLPRL CSLESGKMVY VQGKFYCMNY SPFSVLSYEV TGNRWIKIQA PMRRFLRSPS 

       310        320        330        340        350        360 
LLESKGRLIL VAAVEKSKLN VPKSLRLWSL QQDNATWVEI ERMPQPLYTQ FAAEEGGKGF 

       370        380        390        400        410        420 
ECVGNQEFVM IVLRGTSLQL LFDIVRKSWL WVPPCPYSGS GGGSSGGGSD GEVLQGFAYD 

       430        440 
PVLTTPVVSL LDQLTLPFPG VC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum." Ingram G.C., Goodrich J., Wilkinson M.D., Simon R., Haughn G.W., Coen E.S. Plant Cell 7:1501-1510(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: cv. Landsberg erecta.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function." Krizek B.A., Meyerowitz E.M. Development 122:11-22(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"A LEAFY co-regulator encoded by UNUSUAL FLORAL ORGANS." Lee I., Wolfe D.S., Nilsson O., Weigel D. Curr. Biol. 7:95-104(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[7]	"The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem." Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L. Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"F-box proteins in Arabidopsis." Xiao W., Jang J.-C. Trends Plant Sci. 5:454-457(2000) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[9]	"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis." Zhao D., Yu Q., Chen M., Ma H. Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[10]	"The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis." Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D. Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2 AND ASK11.
[11]	"The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis." Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C. Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SKP1A, DOMAIN.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89224 Genomic DNA. Translation: CAA61508.1. AC000107 Genomic DNA. Translation: AAF98199.1. CP002684 Genomic DNA. Translation: AEE31296.1. DQ056469 mRNA. Translation: AAY78626.1.
IPI	IPI00521563.
PIR	S57710.
RefSeq	NP_564368.1. NM_102834.1.
UniGene	At.51845.
3D structure databases
ProteinModelPortal	Q39090.
SMR	Q39090. Positions 47-92.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q39090. 15 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G30950.1; AT1G30950.1; AT1G30950.
GeneID	839982.
KEGG	ath:AT1G30950.
Organism-specific databases
TAIR	At1g30950.
Phylogenomic databases
eggNOG	NOG303383.
HOGENOM	HOG000084155.
InParanoid	Q39090.
OMA	VEIERMP.
PhylomeDB	Q39090.
ProtClustDB	CLSN2688127.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q39090.
Genevestigator	Q39090.
GermOnline	AT1G30950. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001810. F-box_dom_cyclin-like. [Graphical view]
Pfam	PF00646. F-box. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UFO_ARATH

Accession

Primary (citable) accession number: Q39090
Secondary accession number(s): Q4PT17, Q9FYI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	May 9, 2003
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents