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Q39090

- UFO_ARATH

UniProt

Q39090 - UFO_ARATH

Protein

Protein UNUSUAL FLORAL ORGANS

Gene

UFO

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (09 May 2003)
      Previous versions | rss
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    Functioni

    Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes.By similarity3 Publications

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. transcription factor binding Source: TAIR
    3. ubiquitin-protein transferase activity Source: TAIR

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. flower development Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: TAIR
    4. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: TAIR
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Flowering, Transcription, Transcription regulation, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein UNUSUAL FLORAL ORGANS
    Alternative name(s):
    F-box only protein 1
    Short name:
    AtFBX1
    Gene namesi
    Name:UFO
    Synonyms:FBX1
    Ordered Locus Names:At1g30950
    ORF Names:F17F8.16
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G30950.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Protein UNUSUAL FLORAL ORGANSPRO_0000119966Add
    BLAST

    Proteomic databases

    PRIDEiQ39090.

    Expressioni

    Developmental stagei

    Detected early throughout the shoot apical meristem, but not in the emerging leaf primordia. Restricted later to the junction between sepal and petal primordia.1 Publication

    Gene expression databases

    GenevestigatoriQ39090.

    Interactioni

    Subunit structurei

    Part of a putative SCF (ASK/Cullin/F-box) ubiquitin ligase complex. Interacts with SKP1A/ASK1, SKP1B/ASK2 and ASK11.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ASK11O494843EBI-590758,EBI-401185
    LFYQ009586EBI-590758,EBI-1644366
    SKP1AQ392556EBI-590758,EBI-532357
    SKP1BQ9FHW75EBI-590758,EBI-604076
    SRK2AP432913EBI-590758,EBI-401164

    Protein-protein interaction databases

    BioGridi25217. 15 interactions.
    IntActiQ39090. 15 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39090.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 9047F-boxPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 8585Interaction with SKP1AAdd
    BLAST

    Domaini

    The F-box is necessary for the interaction with ASK proteins.By similarity

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303383.
    HOGENOMiHOG000084155.
    InParanoidiQ39090.
    OMAiVEIERMP.
    PhylomeDBiQ39090.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    [Graphical view]
    PfamiPF00646. F-box. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSTVFINNP SLTLPFSYTF TSSSNSSTTT STTTDSSSGQ WMDGRIWSKL    50
    PPPLLDRVIA FLPPPAFFRT RCVCKRFYSL LFSNTFLETY LQLLPLRHNC 100
    FLFFKHKTLK SYIYKRGGTN DDDSNKAEGF LFDPNEIRWY RLSFAYIPSG 150
    FYPSGSSGGL VSWVSEEAGL KTILLCNPLV GSVSQLPPIS RPRLFPSIGL 200
    SVTPTSIDVT VAGDDLISPY AVKNLSSESF HVDAGGFFSL WAMTSSLPRL 250
    CSLESGKMVY VQGKFYCMNY SPFSVLSYEV TGNRWIKIQA PMRRFLRSPS 300
    LLESKGRLIL VAAVEKSKLN VPKSLRLWSL QQDNATWVEI ERMPQPLYTQ 350
    FAAEEGGKGF ECVGNQEFVM IVLRGTSLQL LFDIVRKSWL WVPPCPYSGS 400
    GGGSSGGGSD GEVLQGFAYD PVLTTPVVSL LDQLTLPFPG VC 442
    Length:442
    Mass (Da):49,047
    Last modified:May 9, 2003 - v2
    Checksum:i6E5C38B0F92AE8B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441G → C in CAA61508. (PubMed:8589630)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89224 Genomic DNA. Translation: CAA61508.1.
    AC000107 Genomic DNA. Translation: AAF98199.1.
    CP002684 Genomic DNA. Translation: AEE31296.1.
    DQ056469 mRNA. Translation: AAY78626.1.
    PIRiS57710.
    RefSeqiNP_564368.1. NM_102834.1.
    UniGeneiAt.51845.

    Genome annotation databases

    EnsemblPlantsiAT1G30950.1; AT1G30950.1; AT1G30950.
    GeneIDi839982.
    KEGGiath:AT1G30950.

    Cross-referencesi

    Web resourcesi

    PlantsUBQ

    A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89224 Genomic DNA. Translation: CAA61508.1 .
    AC000107 Genomic DNA. Translation: AAF98199.1 .
    CP002684 Genomic DNA. Translation: AEE31296.1 .
    DQ056469 mRNA. Translation: AAY78626.1 .
    PIRi S57710.
    RefSeqi NP_564368.1. NM_102834.1.
    UniGenei At.51845.

    3D structure databases

    ProteinModelPortali Q39090.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 25217. 15 interactions.
    IntActi Q39090. 15 interactions.

    Proteomic databases

    PRIDEi Q39090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G30950.1 ; AT1G30950.1 ; AT1G30950 .
    GeneIDi 839982.
    KEGGi ath:AT1G30950.

    Organism-specific databases

    TAIRi AT1G30950.

    Phylogenomic databases

    eggNOGi NOG303383.
    HOGENOMi HOG000084155.
    InParanoidi Q39090.
    OMAi VEIERMP.
    PhylomeDBi Q39090.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Gene expression databases

    Genevestigatori Q39090.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    [Graphical view ]
    Pfami PF00646. F-box. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum."
      Ingram G.C., Goodrich J., Wilkinson M.D., Simon R., Haughn G.W., Coen E.S.
      Plant Cell 7:1501-1510(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: cv. Landsberg erecta.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function."
      Krizek B.A., Meyerowitz E.M.
      Development 122:11-22(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "A LEAFY co-regulator encoded by UNUSUAL FLORAL ORGANS."
      Lee I., Wolfe D.S., Nilsson O., Weigel D.
      Curr. Biol. 7:95-104(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    7. "The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem."
      Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L.
      Plant J. 20:433-445(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. Cited for: GENE FAMILY, NOMENCLATURE.
    9. "The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis."
      Zhao D., Yu Q., Chen M., Ma H.
      Development 128:2735-2746(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    10. "The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis."
      Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2 AND ASK11.
    11. "The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis."
      Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C.
      Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SKP1A, DOMAIN.

    Entry informationi

    Entry nameiUFO_ARATH
    AccessioniPrimary (citable) accession number: Q39090
    Secondary accession number(s): Q4PT17, Q9FYI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: May 9, 2003
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mutations in the UFO gene result in the formation of unusual floral organs.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3