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Protein

Cyclin-A2-1

Gene

CYCA2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication.1 Publication

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-ATH-1538133 G0 and Early G1
R-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-ATH-5689880 Ub-specific processing proteases
R-ATH-5693607 Processing of DNA double-strand break ends
R-ATH-68911 G2 Phase
R-ATH-68949 Orc1 removal from chromatin
R-ATH-69017 CDK-mediated phosphorylation and removal of Cdc6
R-ATH-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-ATH-69656 Cyclin A:Cdk2-associated events at S phase entry
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2-1
Alternative name(s):
Cyc3a-At
Cyclin-3a
G2/mitotic-specific cyclin-A2-1
Short name:
CycA2;1
Gene namesi
Name:CYCA2-1
Synonyms:CYC3A
Ordered Locus Names:At5g25380
ORF Names:F18G18.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G25380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869931 – 443Cyclin-A2-1Add BLAST443

Proteomic databases

PaxDbiQ39071
PRIDEiQ39071

Expressioni

Tissue specificityi

Expressed in tissues with active cell division: apical root and shoot meristems, lateral root and leaf primordia, floral meristems and developing pollen.2 Publications

Developmental stagei

Starts to be expressed during S phase with a maximum just before the G2-to-M boundary and disappears in the metaphase of mitosis. Expressed during embryogenesis in the ovule, integuments, egg cell and synergids, and in the embryo up to late-torpedo stage. Expressed during germination in the root apical meristem, shoot apical meristem, vascular bundles of the cotyledons and vascular cylinder of the roots up to lateral roots emergence. Expressed during flowering in the caulines leaves, peduncle, sepals of flower buds, early expanded petals, ovary, placenta, funiculi, devoloping ovules, pollen connective tissues, tapetum, endothecium, epidermis and developing pollen grains.1 Publication

Inductioni

By auxin in the roots, cytokinin in the shoot apex and sucrose in suspension cell culture. Down-regulated by salt stress in root meristem and shoot apex.2 Publications

Gene expression databases

ExpressionAtlasiQ39071 baseline and differential
GenevisibleiQ39071 AT

Interactioni

Protein-protein interaction databases

BioGridi17885, 12 interactors
IntActiQ39071, 5 interactors
STRINGi3702.AT5G25380.1

Structurei

3D structure databases

ProteinModelPortaliQ39071
SMRiQ39071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
HOGENOMiHOG000167672
InParanoidiQ39071
KOiK06627
OrthoDBiEOG09360C5F

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Q39071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRASSKHTN AKKEAISTSK IRDNNVRVTR SRAKALGVSN SPSKPAFKHE
60 70 80 90 100
TKRVARPSNK RMASDNITVC NQKRRAVLKD VTNTLAESII STEGNVKACK
110 120 130 140 150
RGGKETKQIE EDGLVDVDGE KSKLAEDLSK IRMVESLDAS ASKQKLVDCA
160 170 180 190 200
EEDRSDVTDC VQIVDIDSGV QDPQFCSLYA ASIYDSINVA ELEQRPSTSY
210 220 230 240 250
MVQVQRDIDP TMRGILIDWL VEVSEEYKLV SDTLYLTVNL IDRFMSHNYI
260 270 280 290 300
EKQKLQLLGI TCMLIASKYE EISAPRLEEF CFITDNTYTR LEVLSMEIKV
310 320 330 340 350
LNSLHFRLSV PTTKTFLRRF IRAAQASDKV PLIEMEYLAN YFAELTLTEY
360 370 380 390 400
TFLRFLPSLI AASAVFLARW TLDQSNHPWN QTLQHYTRYE TSALKNTVLA
410 420 430 440
MEELQLNTSG STLIAIHTKY NQQKFKRVAT LTSPERVNTL FSR
Length:443
Mass (Da):50,336
Last modified:December 14, 2011 - v3
Checksum:iA4A8D9707F7A13A5
GO

Sequence cautioni

The sequence AED93433 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97K → RQ in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti144 – 145QK → E in CAA83460 (PubMed:7972055).Curated2
Sequence conflicti204V → L in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti253Q → R in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti260I → V in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti381Q → K in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti397T → A in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti403E → D in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti417H → R in CAA83460 (PubMed:7972055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31589 Genomic DNA Translation: CAA83460.1
AC006258 Genomic DNA Translation: AAC98445.1
CP002688 Genomic DNA Translation: AED93433.1 Sequence problems.
CP002688 Genomic DNA Translation: ANM70898.1
RefSeqiNP_001318646.1, NM_001343923.1
NP_001332473.1, NM_001343925.1
NP_197920.2, NM_122447.3
UniGeneiAt.54993

Genome annotation databases

EnsemblPlantsiAT5G25380.4; AT5G25380.4; AT5G25380
GeneIDi832610
GrameneiAT5G25380.4; AT5G25380.4; AT5G25380
KEGGiath:AT5G25380

Similar proteinsi

Entry informationi

Entry nameiCCA21_ARATH
AccessioniPrimary (citable) accession number: Q39071
Secondary accession number(s): F4JWR7, Q9ZU09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 14, 2011
Last modified: May 23, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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