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Protein

Cyclin-A2-1

Gene

CYCA2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-ATH-113510. E2F mediated regulation of DNA replication.
R-ATH-1538133. G0 and Early G1.
R-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-5689880. Ub-specific processing proteases.
R-ATH-68911. G2 Phase.
R-ATH-68949. Orc1 removal from chromatin.
R-ATH-69205. G1/S-Specific Transcription.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2-1
Alternative name(s):
Cyc3a-At
Cyclin-3a
G2/mitotic-specific cyclin-A2-1
Short name:
CycA2;1
Gene namesi
Name:CYCA2-1
Synonyms:CYC3A
Ordered Locus Names:At5g25380
ORF Names:F18G18.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G25380.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869931 – 443Cyclin-A2-1Add BLAST443

Proteomic databases

PaxDbiQ39071.
PRIDEiQ39071.

Expressioni

Tissue specificityi

Expressed in tissues with active cell division: apical root and shoot meristems, lateral root and leaf primordia, floral meristems and developing pollen.2 Publications

Developmental stagei

Starts to be expressed during S phase with a maximum just before the G2-to-M boundary and disappears in the metaphase of mitosis. Expressed during embryogenesis in the ovule, integuments, egg cell and synergids, and in the embryo up to late-torpedo stage. Expressed during germination in the root apical meristem, shoot apical meristem, vascular bundles of the cotyledons and vascular cylinder of the roots up to lateral roots emergence. Expressed during flowering in the caulines leaves, peduncle, sepals of flower buds, early expanded petals, ovary, placenta, funiculi, devoloping ovules, pollen connective tissues, tapetum, endothecium, epidermis and developing pollen grains.1 Publication

Inductioni

By auxin in the roots, cytokinin in the shoot apex and sucrose in suspension cell culture. Down-regulated by salt stress in root meristem and shoot apex.2 Publications

Gene expression databases

GenevisibleiQ39071. AT.

Interactioni

Protein-protein interaction databases

BioGridi17885. 12 interactors.
IntActiQ39071. 5 interactors.
STRINGi3702.AT5G25380.1.

Structurei

3D structure databases

ProteinModelPortaliQ39071.
SMRiQ39071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ39071.
KOiK06627.
OrthoDBiEOG09360C5F.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRASSKHTN AKKEAISTSK IRDNNVRVTR SRAKALGVSN SPSKPAFKHE
60 70 80 90 100
TKRVARPSNK RMASDNITVC NQKRRAVLKD VTNTLAESII STEGNVKACK
110 120 130 140 150
RGGKETKQIE EDGLVDVDGE KSKLAEDLSK IRMVESLDAS ASKQKLVDCA
160 170 180 190 200
EEDRSDVTDC VQIVDIDSGV QDPQFCSLYA ASIYDSINVA ELEQRPSTSY
210 220 230 240 250
MVQVQRDIDP TMRGILIDWL VEVSEEYKLV SDTLYLTVNL IDRFMSHNYI
260 270 280 290 300
EKQKLQLLGI TCMLIASKYE EISAPRLEEF CFITDNTYTR LEVLSMEIKV
310 320 330 340 350
LNSLHFRLSV PTTKTFLRRF IRAAQASDKV PLIEMEYLAN YFAELTLTEY
360 370 380 390 400
TFLRFLPSLI AASAVFLARW TLDQSNHPWN QTLQHYTRYE TSALKNTVLA
410 420 430 440
MEELQLNTSG STLIAIHTKY NQQKFKRVAT LTSPERVNTL FSR
Length:443
Mass (Da):50,336
Last modified:December 14, 2011 - v3
Checksum:iA4A8D9707F7A13A5
GO

Sequence cautioni

The sequence AED93433 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97K → RQ in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti144 – 145QK → E in CAA83460 (PubMed:7972055).Curated2
Sequence conflicti204V → L in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti253Q → R in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti260I → V in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti381Q → K in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti397T → A in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti403E → D in CAA83460 (PubMed:7972055).Curated1
Sequence conflicti417H → R in CAA83460 (PubMed:7972055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31589 Genomic DNA. Translation: CAA83460.1.
AC006258 Genomic DNA. Translation: AAC98445.1.
CP002688 Genomic DNA. Translation: AED93433.1. Sequence problems.
RefSeqiNP_197920.2. NM_122447.3.
UniGeneiAt.54993.

Genome annotation databases

EnsemblPlantsiAT5G25380.1; AT5G25380.1; AT5G25380.
GeneIDi832610.
GrameneiAT5G25380.1; AT5G25380.1; AT5G25380.
KEGGiath:AT5G25380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31589 Genomic DNA. Translation: CAA83460.1.
AC006258 Genomic DNA. Translation: AAC98445.1.
CP002688 Genomic DNA. Translation: AED93433.1. Sequence problems.
RefSeqiNP_197920.2. NM_122447.3.
UniGeneiAt.54993.

3D structure databases

ProteinModelPortaliQ39071.
SMRiQ39071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17885. 12 interactors.
IntActiQ39071. 5 interactors.
STRINGi3702.AT5G25380.1.

Proteomic databases

PaxDbiQ39071.
PRIDEiQ39071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G25380.1; AT5G25380.1; AT5G25380.
GeneIDi832610.
GrameneiAT5G25380.1; AT5G25380.1; AT5G25380.
KEGGiath:AT5G25380.

Organism-specific databases

TAIRiAT5G25380.

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ39071.
KOiK06627.
OrthoDBiEOG09360C5F.

Enzyme and pathway databases

ReactomeiR-ATH-113510. E2F mediated regulation of DNA replication.
R-ATH-1538133. G0 and Early G1.
R-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-5689880. Ub-specific processing proteases.
R-ATH-68911. G2 Phase.
R-ATH-68949. Orc1 removal from chromatin.
R-ATH-69205. G1/S-Specific Transcription.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.

Miscellaneous databases

PROiQ39071.

Gene expression databases

GenevisibleiQ39071. AT.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCA21_ARATH
AccessioniPrimary (citable) accession number: Q39071
Secondary accession number(s): F4JWR7, Q9ZU09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.