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Protein

Cyclin-B1-2

Gene

CYCB1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May induce mitotic cell division.1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • response to gamma radiation Source: TAIR

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-ATH-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-ATH-2299718. Condensation of Prophase Chromosomes.
R-ATH-2500257. Resolution of Sister Chromatid Cohesion.
R-ATH-4419969. Depolymerisation of the Nuclear Lamina.
R-ATH-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-ATH-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-ATH-69478. G2/M DNA replication checkpoint.
R-ATH-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-B1-2
Alternative name(s):
Cyc1b-At
Cyclin-1b
G2/mitotic-specific cyclin-B1-2
Short name:
CycB1;2
Gene namesi
Name:CYCB1-2
Synonyms:CYC1B
Ordered Locus Names:At5g06150
ORF Names:MBL20.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G06150.
TAIRilocus:2160722. AT5G06150.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002870041 – 445Cyclin-B1-2Add BLAST445

Proteomic databases

PaxDbiQ39067.

PTM databases

iPTMnetiQ39067.

Expressioni

Tissue specificityi

Expressed in roots, stems and flowers.1 Publication

Developmental stagei

Expressed during G2/M and M phases.1 Publication

Inductioni

Transiently down-regulated by salt stress in roots.1 Publication

Gene expression databases

ExpressionAtlasiQ39067. baseline and differential.
GenevisibleiQ39067. AT.

Interactioni

Subunit structurei

Interacts with FZR2/CCS52A1, FZR1/CCS52A2 and FZR3/CCS52B.1 Publication

Protein-protein interaction databases

BioGridi15781. 19 interactors.
IntActiQ39067. 15 interactors.
STRINGi3702.AT5G06150.1.

Structurei

3D structure databases

ProteinModelPortaliQ39067.
SMRiQ39067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ39067.
KOiK21777.
OMAiNEYREIK.
OrthoDBiEOG09360JD9.
PhylomeDBiQ39067.

Family and domain databases

CDDicd00043. CYCLIN. 2 hits.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRANVPEQ VRGAPLVDGL KIQNKNGAVK SRRALGDIGN LVSVPGVQGG
60 70 80 90 100
KAQPPINRPI TRSFRAQLLA NAQLERKPIN GDNKVPALGP KRQPLAARNP
110 120 130 140 150
EAQRAVQKKN LVVKQQTKPV EVIETKKEVT KKEVAMSPKN KKVTYSSVLS
160 170 180 190 200
ARSKAACGIV NKPKIIDIDE SDKDNHLAAV EYVDDMYSFY KEVEKESQPK
210 220 230 240 250
MYMHIQTEMN EKMRAILIDW LLEVHIKFEL NLETLYLTVN IIDRFLSVKA
260 270 280 290 300
VPKRELQLVG ISALLIASKY EEIWPPQVND LVYVTDNAYS SRQILVMEKA
310 320 330 340 350
ILGNLEWYLT VPTQYVFLVR FIKASMSDPE MENMVHFLAE LGMMHYDTLT
360 370 380 390 400
FCPSMLAASA VYTARCSLNK SPAWTDTLQF HTGYTESEIM DCSKLLAFLH
410 420 430 440
SRCGESRLRA VYKKYSKAEN GGVAMVSPAK SLLSAAADWK KPVSS
Length:445
Mass (Da):49,847
Last modified:May 15, 2007 - v2
Checksum:i6FA9A8A73296E095
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200K → R in AAB02028 (PubMed:8193159).Curated1
Sequence conflicti356L → Q in AAB02028 (PubMed:8193159).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27223 mRNA. Translation: AAB02028.1.
AP002544 Genomic DNA. Translation: BAB09680.1.
CP002688 Genomic DNA. Translation: AED90976.1.
PIRiS65734.
RefSeqiNP_196233.1. NM_120697.3.
UniGeneiAt.8011.

Genome annotation databases

EnsemblPlantsiAT5G06150.1; AT5G06150.1; AT5G06150.
GeneIDi830502.
GrameneiAT5G06150.1; AT5G06150.1; AT5G06150.
KEGGiath:AT5G06150.

Similar proteinsi

Entry informationi

Entry nameiCCB12_ARATH
AccessioniPrimary (citable) accession number: Q39067
Secondary accession number(s): Q9FG02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 25, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families