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Protein

Phosphoinositide phospholipase C 1

Gene

PLC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for secondary responses to abscisic acid signals.3 Publications

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei120PROSITE-ProRule annotation1
Active sitei166PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • abscisic acid-activated signaling pathway Source: TAIR
  • intracellular signal transduction Source: InterPro
  • lipid catabolic process Source: UniProtKB-KW
  • response to abscisic acid Source: TAIR
  • response to cold Source: TAIR
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:MONOMER-1622
MetaCyc:MONOMER-1622
BRENDAi3.1.4.11 399
ReactomeiR-ATH-112043 PLC beta mediated events
R-ATH-114604 GPVI-mediated activation cascade
R-ATH-1855204 Synthesis of IP3 and IP4 in the cytosol
R-ATH-202433 Generation of second messenger molecules
R-ATH-399997 Acetylcholine regulates insulin secretion
R-ATH-416476 G alpha (q) signalling events
R-ATH-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-ATH-5607764 CLEC7A (Dectin-1) signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC1
Short name:
AtPLC1
Short name:
AtPLC1S
Short name:
PI-PLC1
Gene namesi
Name:PLC1
Synonyms:ATHATPLC1G
Ordered Locus Names:At5g58670
ORF Names:MZN1.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G58670
TAIRilocus:2178803 AT5G58670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241261 – 561Phosphoinositide phospholipase C 1Add BLAST561

Proteomic databases

PaxDbiQ39032
PRIDEiQ39032

PTM databases

iPTMnetiQ39032
SwissPalmiQ39032

Expressioni

Tissue specificityi

Expressed in stems, leaves, roots, flowers and siliques. Predominant in the vascular tissues of roots and leaves.2 Publications

Inductioni

By abscisic acid, osmotic stress and environmental stresses such as dehydration, salinity and low temperature.2 Publications

Gene expression databases

ExpressionAtlasiQ39032 baseline and differential
GenevisibleiQ39032 AT

Interactioni

Protein-protein interaction databases

BioGridi21225, 1 interactor
STRINGi3702.AT5G58670.1

Structurei

3D structure databases

ProteinModelPortaliQ39032
SMRiQ39032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 54EF-handAdd BLAST34
Domaini105 – 249PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini294 – 410PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini417 – 524C2PROSITE-ProRule annotationAdd BLAST108

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
HOGENOMiHOG000244119
InParanoidiQ39032
KOiK05857
OMAiLFQCTDE
OrthoDBiEOG0936050V
PhylomeDBiQ39032

Family and domain databases

Gene3Di2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q39032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESFKVCFC CVRNFKVKSS EPPEEIKNLF HDYSQDDRMS ADEMLRFVIQ
60 70 80 90 100
VQGETHADIN YVKDIFHRLK HHGVFHPRGI HLEGFYRYLL SDFNSPLPLT
110 120 130 140 150
REVWQDMNQP LSHYFLYTGH NSYLTGNQLN SNSSIEPIVK ALRNGVRVIE
160 170 180 190 200
LDLWPNSSGK EAEVRHGGTL TSREDLQKCL NVVKENAFQV SAYPVVLTLE
210 220 230 240 250
DHLTPILQKK VAKMVSKTFG GSLFQCTDET TECFPSPESL KNKILISTKP
260 270 280 290 300
PKEYLQTQIS KGSTTDESTR AKKISDAEEQ VQEEDEESVA IEYRDLISIH
310 320 330 340 350
AGNRKGGLKN CLNGDPNRVI RLSMSEQWLE TLAKTRGPDL VKFTQRNLLR
360 370 380 390 400
IFPKTTRFDS SNYDPLVGWI HGAQMVAFNM QSHGRYLWMM QGMFKANGGC
410 420 430 440 450
GYVKKPDVLL SNGPEGEIFD PCSQNLPIKT TLKVKIYTGE GWNMDFPLDH
460 470 480 490 500
FDRYSPPDFY AKVGIAGVPL DTASYRTEID KDEWFPIWDK EFEFPLRVPE
510 520 530 540 550
LSLLCITVKD YDSNTQNDFA GQTCFPLSEV RPGIRAVRLH DRAGEVYKHV
560
RLLMRFVLEP R
Length:561
Mass (Da):64,314
Last modified:November 1, 1996 - v1
Checksum:iA05AD123411352E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87R → G in AAC05023 (PubMed:9427559).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38544 mRNA Translation: BAA07547.1
U76423 Genomic DNA Translation: AAC05023.1
AB020755 Genomic DNA Translation: BAA97336.1
CP002688 Genomic DNA Translation: AED97083.1
RefSeqiNP_568881.1, NM_125254.2
UniGeneiAt.10551

Genome annotation databases

EnsemblPlantsiAT5G58670.1; AT5G58670.1; AT5G58670
GeneIDi835981
GrameneiAT5G58670.1; AT5G58670.1; AT5G58670
KEGGiath:AT5G58670

Similar proteinsi

Entry informationi

Entry nameiPLCD1_ARATH
AccessioniPrimary (citable) accession number: Q39032
Secondary accession number(s): O49970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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