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Q39026 (MPK6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 6

Short name=AtMPK6
Short name=MAP kinase 6
EC=2.7.11.24
Gene names
Name:MPK6
Ordered Locus Names:At2g43790
ORF Names:F18O19.10
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade. May phosphorylate regulators of WRKY transcription factors. Phosphorylates 1-aminocyclopropane-1-carboxylic acid synthases (ACS2 and ACS6) and may be involved in the regulation of bacterial elicitor flagellin-induced ethylene production. Regulates locally gene-mediated and basal resistance response to certain pathogens. May be involved in the cold and salinity stress-mediated MAP kinase signaling cascade (MEKK1, MKK1/MKK2 and MPK4/MPK6). MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H2O2 production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination. MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression. MKK9-MPK3/MPK6 module phosphorylates and activates EIN3, leading to the promotion of EIN3-mediated transcription in ethylene signaling. MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection. MKK9-MPK6 module positively regulates leaf senescence. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. Ref.11 Ref.15 Ref.16 Ref.17 Ref.20 Ref.24 Ref.25 Ref.28 Ref.29 Ref.31 Ref.34 Ref.35 Ref.40

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation. Activated by the MAP kinase kinases MKK2, MKK3, MKK4, MKK5, MKK7 and MKK9. Activated in response to touch, wounding, low temperature, low humidity, salt stress, hydrogen peroxide, ozone, ACC (an ethylene precursor), jasmonic acid (JA), mastoparan and UVC. Activated in response to elicitors: oligogalacturonides, hexameric chitin fragments, fungal xylanase, and the bacterial flagellin and harpin. Activated upon Pseudomonas syringae pv. tomato DC3000 infection. Repressed by the protein phosphatase 2C AP2C1 and the protein-tyrosine-phosphatases MKP1 and PTP1. Repressed by DSPTP1B/MKP2-mediated dephosphorylation. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.13 Ref.15 Ref.18 Ref.19 Ref.22 Ref.23 Ref.25 Ref.26 Ref.27 Ref.28 Ref.33 Ref.35

Subunit structure

Interacts with MEKK1, MKK1 and MKK2. May form a ternary complex with MEKK1 and MKK1 or MKK2. Interacts with NDPK2, AP2C1, MKP1 and PTP1. Interacts with DSPTP1B/MKP2, especially during HR-like responses triggered by fungal elicitors. Interacts with MKK4, MKK5 and MKK6. Ref.14 Ref.15 Ref.26 Ref.30 Ref.33 Ref.36 Ref.37 Ref.38

Subcellular location

Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation Probable. Ref.18 Ref.28 Ref.32

Induction

By Alternaria brassicae pathogen infection. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.13 Ref.15 Ref.18 Ref.19 Ref.22 Ref.23 Ref.25 Ref.26 Ref.27 Ref.28 Ref.33 Ref.35 Ref.39

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-221 and Tyr-223, which activates the enzyme. Dephosphorylated by DSPTP1B/MKP2. Ref.5 Ref.6 Ref.22 Ref.33

Disruption phenotype

Reduced sensitivity to abscisic acid (ABA) during germination. Delayed senescence phenotype. Ref.34 Ref.35

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processHypersensitive response
Plant defense
Stress response
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcamalexin biosynthetic process

Inferred from mutant phenotype Ref.31. Source: TAIR

cell division

Inferred from mutant phenotype PubMed 19832943. Source: TAIR

defense response to bacterium

Inferred from expression pattern Ref.11. Source: TAIR

induced systemic resistance, jasmonic acid mediated signaling pathway

Inferred from mutant phenotype Ref.25. Source: TAIR

inflorescence development

Inferred from mutant phenotype Ref.40. Source: TAIR

leaf senescence

Inferred from mutant phenotype Ref.35. Source: UniProtKB

ovule development

Inferred from genetic interaction PubMed 18364464. Source: TAIR

plant-type hypersensitive response

Inferred from electronic annotation. Source: UniProtKB-KW

priming of cellular response to stress

Inferred from mutant phenotype PubMed 19318610. Source: TAIR

regulation of stomatal complex development

Inferred from genetic interaction Ref.24. Source: TAIR

regulation of stomatal complex patterning

Inferred from genetic interaction Ref.24. Source: TAIR

response to UV-B

Inferred from mutant phenotype PubMed 21790814. Source: TAIR

response to abscisic acid

Inferred from expression pattern Ref.29. Source: TAIR

response to cold

Inferred from direct assay Ref.15. Source: TAIR

response to ethylene

Inferred from direct assay Ref.13. Source: TAIR

response to fungus

Inferred from expression pattern Ref.39. Source: UniProtKB

response to hydrogen peroxide

Inferred from direct assay Ref.27. Source: TAIR

response to osmotic stress

Inferred from direct assay Ref.10. Source: TAIR

response to oxidative stress

Inferred from expression pattern Ref.7. Source: TAIR

response to reactive oxygen species

Inferred from expression pattern Ref.8. Source: TAIR

response to salt stress

Inferred from genetic interaction Ref.15. Source: TAIR

root development

Inferred from mutant phenotype PubMed 19832943. Source: TAIR

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

phragmoplast

Inferred from direct assay PubMed 19832943. Source: TAIR

preprophase band

Inferred from direct assay PubMed 19832943. Source: TAIR

trans-Golgi network

Inferred from direct assay PubMed 19832943. Source: TAIR

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from direct assay Ref.5. Source: TAIR

protein binding

Inferred from physical interaction Ref.33Ref.36. Source: UniProtKB

protein kinase activity

Inferred from direct assay PubMed 22631074. Source: TAIR

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Mitogen-activated protein kinase 6
PRO_0000186315

Regions

Domain63 – 348286Protein kinase
Nucleotide binding69 – 779ATP By similarity
Motif221 – 2233TXY

Sites

Active site1891Proton acceptor By similarity
Binding site921ATP

Amino acid modifications

Modified residue2211Phosphothreonine Ref.5
Modified residue2231Phosphotyrosine Ref.5
Modified residue2261Phosphothreonine Ref.32

Experimental info

Mutagenesis921K → M: Loss of kinase activity. Ref.11
Mutagenesis931K → M: Loss of kinase activity. Ref.11

Sequences

Sequence LengthMass (Da)Tools
Q39026 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 296D2BD753C6DDA4

FASTA39545,058
        10         20         30         40         50         60 
MDGGSGQPAA DTEMTEAPGG FPAAAPSPQM PGIENIPATL SHGGRFIQYN IFGNIFEVTA 

        70         80         90        100        110        120 
KYKPPIMPIG KGAYGIVCSA MNSETNESVA IKKIANAFDN KIDAKRTLRE IKLLRHMDHE 

       130        140        150        160        170        180 
NIVAIRDIIP PPLRNAFNDV YIAYELMDTD LHQIIRSNQA LSEEHCQYFL YQILRGLKYI 

       190        200        210        220        230        240 
HSANVLHRDL KPSNLLLNAN CDLKICDFGL ARVTSESDFM TEYVVTRWYR APELLLNSSD 

       250        260        270        280        290        300 
YTAAIDVWSV GCIFMELMDR KPLFPGRDHV HQLRLLMELI GTPSEEELEF LNENAKRYIR 

       310        320        330        340        350        360 
QLPPYPRQSI TDKFPTVHPL AIDLIEKMLT FDPRRRITVL DALAHPYLNS LHDISDEPEC 

       370        380        390 
TIPFNFDFEN HALSEEQMKE LIYREALAFN PEYQQ 

« Hide

References

« Hide 'large scale' references
[1]"ATMPKs: a gene family of plant MAP kinases in Arabidopsis thaliana."
Mizoguchi T., Hayashida N., Yamaguchi-Shinozaki K., Kamada H., Shinozaki K.
FEBS Lett. 336:440-444(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Microbial elicitors induce activation and dual phosphorylation of the Arabidopsis thaliana MAPK 6."
Nuehse T.S., Peck S.C., Hirt H., Boller T.
J. Biol. Chem. 275:7521-7526(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-221 AND TYR-223.
[6]"Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6."
Ichimura K., Mizoguchi T., Yoshida R., Yuasa T., Shinozaki K.
Plant J. 24:655-665(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, PHOSPHORYLATION.
[7]"Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants."
Kovtun Y., Chiu W.-L., Tena G., Sheen J.
Proc. Natl. Acad. Sci. U.S.A. 97:2940-2945(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[8]"Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase."
Yuasa T., Ichimura K., Mizoguchi T., Shinozaki K.
Plant Cell Physiol. 42:1012-1016(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[9]"Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6."
Desikan R., Hancock J.T., Ichimura K., Shinozaki K., Neill S.J.
Plant Physiol. 126:1579-1587(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[10]"Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6."
Droillard M.-J., Boudsocq M., Barbier-Brygoo H., Lauriere C.
FEBS Lett. 527:43-50(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[11]"MAP kinase signalling cascade in Arabidopsis innate immunity."
Asai T., Tena G., Plotnikova J., Willmann M.R., Chiu W.-L., Gomez-Gomez L., Boller T., Ausubel F.M., Sheen J.
Nature 415:977-983(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF LYS-92 AND LYS-93.
[12]"Mitogen-activated protein kinase cascades in plants: a new nomenclature."
MAPK group
Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[13]"A MAPK pathway mediates ethylene signaling in plants."
Ouaked F., Rozhon W., Lecourieux D., Hirt H.
EMBO J. 22:1282-1288(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[14]"NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants."
Moon H., Lee B., Choi G., Shin D., Prasad D.T., Lee O., Kwak S.-S., Kim D.H., Nam J., Bahk J., Hong J.C., Lee S.Y., Cho M.J., Lim C.O., Yun D.-J.
Proc. Natl. Acad. Sci. U.S.A. 100:358-363(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NDPK2.
[15]"The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis."
Teige M., Scheikl E., Eulgem T., Doczi R., Ichimura K., Shinozaki K., Dangl J.L., Hirt H.
Mol. Cell 15:141-152(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ENZYME REGULATION, INTERACTION WITH MKK2.
[16]"Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis."
Menke F.L.H., van Pelt J.A., Pieterse C.M.J., Klessig D.F.
Plant Cell 16:897-907(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[17]"Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis."
Liu Y., Zhang S.
Plant Cell 16:3386-3399(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[18]"Stress hormone-independent activation and nuclear translocation of mitogen-activated protein kinases in Arabidopsis thaliana during ozone exposure."
Ahlfors R., Macioszek V., Rudd J., Brosche M., Schlichting R., Scheel D., Kangasjarvi J.
Plant J. 40:512-522(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, SUBCELLULAR LOCATION.
[19]"Mastoparan rapidly activates plant MAP kinase signaling independent of heterotrimeric G proteins."
Miles G.P., Samuel M.A., Jones A.M., Ellis B.E.
Plant Physiol. 134:1332-1336(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[20]"RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3."
Miles G.P., Samuel M.A., Zhang Y., Ellis B.E.
Environ. Pollut. 138:230-237(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[21]"Ancient signals: comparative genomics of plant MAPK and MAPKK gene families."
Hamel L.P., Nicole M.C., Sritubtim S., Morency M.J., Ellis M., Ehlting J., Beaudoin N., Barbazuk B., Klessig D., Lee J., Martin G., Mundy J., Ohashi Y., Scheel D., Sheen J., Xing T., Zhang S., Seguin A., Ellis B.E.
Trends Plant Sci. 11:192-198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
[22]"Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs."
Lee J.S., Ellis B.E.
J. Biol. Chem. 282:25020-25029(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, DEPHOSPHORYLATION.
[23]"The MAP kinase kinase MKK2 affects disease resistance in Arabidopsis."
Brader G., Djamei A., Teige M., Palva E.T., Hirt H.
Mol. Plant Microbe Interact. 20:589-596(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[24]"Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis."
Wang H., Ngwenyama N., Liu Y., Walker J.C., Zhang S.
Plant Cell 19:63-73(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[25]"The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis."
Takahashi F., Yoshida R., Ichimura K., Mizoguchi T., Seo S., Yonezawa M., Maruyama K., Yamaguchi-Shinozaki K., Shinozaki K.
Plant Cell 19:805-818(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, FUNCTION.
[26]"The PP2C-type phosphatase AP2C1, which negatively regulates MPK4 and MPK6, modulates innate immunity, jasmonic acid, and ethylene levels in Arabidopsis."
Schweighofer A., Kazanaviciute V., Scheikl E., Teige M., Doczi R., Hirt H., Schwanninger M., Kant M., Schuurink R., Mauch F., Buchala A., Cardinale F., Meskiene I.
Plant Cell 19:2213-2224(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, INTERACTION WITH AP2C1.
[27]"The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling."
Doczi R., Brader G., Pettko-Szandtner A., Rajh I., Djamei A., Pitzschke A., Teige M., Hirt H.
Plant Cell 19:3266-3279(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[28]"Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling."
Yoo S.D., Cho Y.H., Tena G., Xiong Y., Sheen J.
Nature 451:789-795(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION.
[29]"AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis."
Xing Y., Jia W., Zhang J.
Plant J. 54:440-451(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[30]"Comprehensive analysis of protein-protein interactions between Arabidopsis MAPKs and MAPK kinases helps define potential MAPK signalling modules."
Lee J.S., Huh K.W., Bhargava A., Ellis B.E.
Plant Signal. Behav. 3:1037-1041(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MKK2; MKK4; MKK5 AND MKK6.
[31]"A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis."
Ren D., Liu Y., Yang K.Y., Han L., Mao G., Glazebrook J., Zhang S.
Proc. Natl. Acad. Sci. U.S.A. 105:5638-5643(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[32]"Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-226, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: cv. Columbia.
[33]"MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis."
Bartels S., Anderson J.C., Gonzalez Besteiro M.A., Carreri A., Hirt H., Buchala A., Metraux J.P., Peck S.C., Ulm R.
Plant Cell 21:2884-2897(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, DEPHOSPHORYLATION, INTERACTION WITH MKP1 AND PTP1.
[34]"AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination."
Xing Y., Jia W., Zhang J.
Plant Mol. Biol. 70:725-736(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[35]"An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence."
Zhou C., Cai Z., Guo Y., Gan S.
Plant Physiol. 150:167-177(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ENZYME REGULATION, DISRUPTION PHENOTYPE.
[36]"MAPK phosphatase MKP2 mediates disease responses in Arabidopsis and functionally interacts with MPK3 and MPK6."
Lumbreras V., Vilela B., Irar S., Sole M., Capellades M., Valls M., Coca M., Pages M.
Plant J. 63:1017-1030(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DSPTP1B/MKP2.
[37]"Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2."
Vilela B., Pages M., Lumbreras V.
Plant Signal. Behav. 5:1497-1500(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DSPTP1B/MKP2.
[38]"AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis."
Zeng Q., Chen J.G., Ellis B.E.
Plant J. 67:895-906(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MKK6.
[39]"Expression analysis of MAP2K9 and MAPK6 during pathogenesis of Alternaria blight in Arabidopsis thaliana ecotype Columbia."
Kannan P., Pandey D., Gupta A.K., Punetha H., Taj G., Kumar A.
Mol. Biol. Rep. 39:4439-4444(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY PATHOGEN.
[40]"A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation."
Meng X., Wang H., He Y., Liu Y., Walker J.C., Torii K.U., Zhang S.
Plant Cell 24:4948-4960(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21842 mRNA. Translation: BAA04869.1.
AC002333 Genomic DNA. Translation: AAB64027.1.
CP002685 Genomic DNA. Translation: AEC10325.1.
AY120737 mRNA. Translation: AAM53295.1.
BT008855 mRNA. Translation: AAP68294.1.
PIRS40472.
RefSeqNP_181907.1. NM_129941.3.
UniGeneAt.22266.
At.53112.

3D structure databases

ProteinModelPortalQ39026.
SMRQ39026. Positions 5-388.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid4318. 20 interactions.
DIPDIP-31825N.
IntActQ39026. 12 interactions.
MINTMINT-8086250.
STRING3702.AT2G43790.1-P.

Proteomic databases

PaxDbQ39026.
PRIDEQ39026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G43790.1; AT2G43790.1; AT2G43790.
GeneID818982.
KEGGath:AT2G43790.

Organism-specific databases

GeneFarm821. 89.
TAIRAT2G43790.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
InParanoidQ39026.
KOK14512.
OMASDEPVCS.
PhylomeDBQ39026.

Enzyme and pathway databases

BioCycARA:AT2G43790-MONOMER.
BRENDA2.7.11.24. 399.

Gene expression databases

GenevestigatorQ39026.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ39026.

Entry information

Entry nameMPK6_ARATH
AccessionPrimary (citable) accession number: Q39026
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names