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Q39026

- MPK6_ARATH

UniProt

Q39026 - MPK6_ARATH

Protein

Mitogen-activated protein kinase 6

Gene

MPK6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade. May phosphorylate regulators of WRKY transcription factors. Phosphorylates 1-aminocyclopropane-1-carboxylic acid synthases (ACS2 and ACS6) and may be involved in the regulation of bacterial elicitor flagellin-induced ethylene production. Regulates locally gene-mediated and basal resistance response to certain pathogens. May be involved in the cold and salinity stress-mediated MAP kinase signaling cascade (MEKK1, MKK1/MKK2 and MPK4/MPK6). MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H2O2 production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination. MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression. MKK9-MPK3/MPK6 module phosphorylates and activates EIN3, leading to the promotion of EIN3-mediated transcription in ethylene signaling. MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection. MKK9-MPK6 module positively regulates leaf senescence. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs.13 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation. Activated by the MAP kinase kinases MKK2, MKK3, MKK4, MKK5, MKK7 and MKK9. Activated in response to touch, wounding, low temperature, low humidity, salt stress, hydrogen peroxide, ozone, ACC (an ethylene precursor), jasmonic acid (JA), mastoparan and UVC. Activated in response to elicitors: oligogalacturonides, hexameric chitin fragments, fungal xylanase, and the bacterial flagellin and harpin. Activated upon Pseudomonas syringae pv. tomato DC3000 infection. Repressed by the protein phosphatase 2C AP2C1 and the protein-tyrosine-phosphatases MKP1 and PTP1. Repressed by DSPTP1B/MKP2-mediated dephosphorylation.18 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921ATP
    Active sitei189 – 1891Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 779ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: TAIR
    3. protein binding Source: UniProtKB
    4. protein kinase activity Source: TAIR

    GO - Biological processi

    1. camalexin biosynthetic process Source: TAIR
    2. cell division Source: TAIR
    3. defense response to bacterium Source: TAIR
    4. induced systemic resistance, jasmonic acid mediated signaling pathway Source: TAIR
    5. inflorescence development Source: TAIR
    6. leaf senescence Source: UniProtKB
    7. ovule development Source: TAIR
    8. plant-type hypersensitive response Source: UniProtKB-KW
    9. priming of cellular response to stress Source: TAIR
    10. regulation of stomatal complex development Source: TAIR
    11. regulation of stomatal complex patterning Source: TAIR
    12. response to abscisic acid Source: TAIR
    13. response to cold Source: TAIR
    14. response to ethylene Source: TAIR
    15. response to fungus Source: UniProtKB
    16. response to hydrogen peroxide Source: TAIR
    17. response to osmotic stress Source: TAIR
    18. response to oxidative stress Source: TAIR
    19. response to reactive oxygen species Source: TAIR
    20. response to salt stress Source: TAIR
    21. response to UV-B Source: TAIR
    22. root development Source: TAIR

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Hypersensitive response, Plant defense, Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G43790-MONOMER.
    BRENDAi2.7.11.24. 399.
    ReactomeiREACT_190855. CREB phosphorylation through the activation of Ras.
    REACT_190946. KSRP destabilizes mRNA.
    REACT_202229. ERK1 activation.
    REACT_208246. ERKs are inactivated.
    REACT_209747. ERK2 activation.
    REACT_216613. Signalling to ERK5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 6 (EC:2.7.11.24)
    Short name:
    AtMPK6
    Short name:
    MAP kinase 6
    Gene namesi
    Name:MPK6
    Ordered Locus Names:At2g43790
    ORF Names:F18O19.10
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G43790.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Translocated into the nucleus in response to phosphorylation.Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. phragmoplast Source: TAIR
    3. preprophase band Source: TAIR
    4. trans-Golgi network Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Reduced sensitivity to abscisic acid (ABA) during germination. Delayed senescence phenotype.2 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi92 – 921K → M: Loss of kinase activity. 1 Publication
    Mutagenesisi93 – 931K → M: Loss of kinase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Mitogen-activated protein kinase 6PRO_0000186315Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei221 – 2211Phosphothreonine2 Publications
    Modified residuei223 – 2231Phosphotyrosine2 Publications
    Modified residuei226 – 2261Phosphothreonine2 Publications

    Post-translational modificationi

    Dually phosphorylated on Thr-221 and Tyr-223, which activates the enzyme. Dephosphorylated by DSPTP1B/MKP2.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ39026.
    PRIDEiQ39026.

    Expressioni

    Inductioni

    By Alternaria brassicae pathogen infection.1 Publication

    Gene expression databases

    GenevestigatoriQ39026.

    Interactioni

    Subunit structurei

    Interacts with MEKK1, MKK1 and MKK2. May form a ternary complex with MEKK1 and MKK1 or MKK2. Interacts with NDPK2, AP2C1, MKP1 and PTP1. Interacts with DSPTP1B/MKP2, especially during HR-like responses triggered by fungal elicitors. Interacts with MKK4, MKK5 and MKK6.8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    At2g47060O807193EBI-349548,EBI-4436376
    ERF104Q9FKG13EBI-349548,EBI-2360943
    MKK2Q9S7U95EBI-349548,EBI-994350

    Protein-protein interaction databases

    BioGridi4318. 20 interactions.
    DIPiDIP-31825N.
    IntActiQ39026. 12 interactions.
    MINTiMINT-8086250.
    STRINGi3702.AT2G43790.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39026.
    SMRiQ39026. Positions 5-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 348286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi221 – 2233TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    InParanoidiQ39026.
    KOiK14512.
    OMAiSDEPVCS.
    PhylomeDBiQ39026.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGGSGQPAA DTEMTEAPGG FPAAAPSPQM PGIENIPATL SHGGRFIQYN    50
    IFGNIFEVTA KYKPPIMPIG KGAYGIVCSA MNSETNESVA IKKIANAFDN 100
    KIDAKRTLRE IKLLRHMDHE NIVAIRDIIP PPLRNAFNDV YIAYELMDTD 150
    LHQIIRSNQA LSEEHCQYFL YQILRGLKYI HSANVLHRDL KPSNLLLNAN 200
    CDLKICDFGL ARVTSESDFM TEYVVTRWYR APELLLNSSD YTAAIDVWSV 250
    GCIFMELMDR KPLFPGRDHV HQLRLLMELI GTPSEEELEF LNENAKRYIR 300
    QLPPYPRQSI TDKFPTVHPL AIDLIEKMLT FDPRRRITVL DALAHPYLNS 350
    LHDISDEPEC TIPFNFDFEN HALSEEQMKE LIYREALAFN PEYQQ 395
    Length:395
    Mass (Da):45,058
    Last modified:November 1, 1996 - v1
    Checksum:i296D2BD753C6DDA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21842 mRNA. Translation: BAA04869.1.
    AC002333 Genomic DNA. Translation: AAB64027.1.
    CP002685 Genomic DNA. Translation: AEC10325.1.
    AY120737 mRNA. Translation: AAM53295.1.
    BT008855 mRNA. Translation: AAP68294.1.
    PIRiS40472.
    RefSeqiNP_181907.1. NM_129941.3.
    UniGeneiAt.22266.
    At.53112.

    Genome annotation databases

    EnsemblPlantsiAT2G43790.1; AT2G43790.1; AT2G43790.
    GeneIDi818982.
    KEGGiath:AT2G43790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21842 mRNA. Translation: BAA04869.1 .
    AC002333 Genomic DNA. Translation: AAB64027.1 .
    CP002685 Genomic DNA. Translation: AEC10325.1 .
    AY120737 mRNA. Translation: AAM53295.1 .
    BT008855 mRNA. Translation: AAP68294.1 .
    PIRi S40472.
    RefSeqi NP_181907.1. NM_129941.3.
    UniGenei At.22266.
    At.53112.

    3D structure databases

    ProteinModelPortali Q39026.
    SMRi Q39026. Positions 5-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 4318. 20 interactions.
    DIPi DIP-31825N.
    IntActi Q39026. 12 interactions.
    MINTi MINT-8086250.
    STRINGi 3702.AT2G43790.1-P.

    Proteomic databases

    PaxDbi Q39026.
    PRIDEi Q39026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G43790.1 ; AT2G43790.1 ; AT2G43790 .
    GeneIDi 818982.
    KEGGi ath:AT2G43790.

    Organism-specific databases

    GeneFarmi 821. 89.
    TAIRi AT2G43790.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    InParanoidi Q39026.
    KOi K14512.
    OMAi SDEPVCS.
    PhylomeDBi Q39026.

    Enzyme and pathway databases

    BioCyci ARA:AT2G43790-MONOMER.
    BRENDAi 2.7.11.24. 399.
    Reactomei REACT_190855. CREB phosphorylation through the activation of Ras.
    REACT_190946. KSRP destabilizes mRNA.
    REACT_202229. ERK1 activation.
    REACT_208246. ERKs are inactivated.
    REACT_209747. ERK2 activation.
    REACT_216613. Signalling to ERK5.

    Miscellaneous databases

    PROi Q39026.

    Gene expression databases

    Genevestigatori Q39026.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ATMPKs: a gene family of plant MAP kinases in Arabidopsis thaliana."
      Mizoguchi T., Hayashida N., Yamaguchi-Shinozaki K., Kamada H., Shinozaki K.
      FEBS Lett. 336:440-444(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Microbial elicitors induce activation and dual phosphorylation of the Arabidopsis thaliana MAPK 6."
      Nuehse T.S., Peck S.C., Hirt H., Boller T.
      J. Biol. Chem. 275:7521-7526(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-221 AND TYR-223.
    6. "Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6."
      Ichimura K., Mizoguchi T., Yoshida R., Yuasa T., Shinozaki K.
      Plant J. 24:655-665(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, PHOSPHORYLATION.
    7. "Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants."
      Kovtun Y., Chiu W.-L., Tena G., Sheen J.
      Proc. Natl. Acad. Sci. U.S.A. 97:2940-2945(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    8. "Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase."
      Yuasa T., Ichimura K., Mizoguchi T., Shinozaki K.
      Plant Cell Physiol. 42:1012-1016(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    9. "Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6."
      Desikan R., Hancock J.T., Ichimura K., Shinozaki K., Neill S.J.
      Plant Physiol. 126:1579-1587(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    10. "Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6."
      Droillard M.-J., Boudsocq M., Barbier-Brygoo H., Lauriere C.
      FEBS Lett. 527:43-50(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    11. Cited for: FUNCTION, MUTAGENESIS OF LYS-92 AND LYS-93.
    12. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
      MAPK group
      Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    13. "A MAPK pathway mediates ethylene signaling in plants."
      Ouaked F., Rozhon W., Lecourieux D., Hirt H.
      EMBO J. 22:1282-1288(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    14. "NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants."
      Moon H., Lee B., Choi G., Shin D., Prasad D.T., Lee O., Kwak S.-S., Kim D.H., Nam J., Bahk J., Hong J.C., Lee S.Y., Cho M.J., Lim C.O., Yun D.-J.
      Proc. Natl. Acad. Sci. U.S.A. 100:358-363(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NDPK2.
    15. "The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis."
      Teige M., Scheikl E., Eulgem T., Doczi R., Ichimura K., Shinozaki K., Dangl J.L., Hirt H.
      Mol. Cell 15:141-152(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, INTERACTION WITH MKK2.
    16. "Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis."
      Menke F.L.H., van Pelt J.A., Pieterse C.M.J., Klessig D.F.
      Plant Cell 16:897-907(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis."
      Liu Y., Zhang S.
      Plant Cell 16:3386-3399(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    18. "Stress hormone-independent activation and nuclear translocation of mitogen-activated protein kinases in Arabidopsis thaliana during ozone exposure."
      Ahlfors R., Macioszek V., Rudd J., Brosche M., Schlichting R., Scheel D., Kangasjarvi J.
      Plant J. 40:512-522(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, SUBCELLULAR LOCATION.
    19. "Mastoparan rapidly activates plant MAP kinase signaling independent of heterotrimeric G proteins."
      Miles G.P., Samuel M.A., Jones A.M., Ellis B.E.
      Plant Physiol. 134:1332-1336(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    20. "RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3."
      Miles G.P., Samuel M.A., Zhang Y., Ellis B.E.
      Environ. Pollut. 138:230-237(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    21. Cited for: GENE FAMILY.
    22. "Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs."
      Lee J.S., Ellis B.E.
      J. Biol. Chem. 282:25020-25029(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, DEPHOSPHORYLATION.
    23. "The MAP kinase kinase MKK2 affects disease resistance in Arabidopsis."
      Brader G., Djamei A., Teige M., Palva E.T., Hirt H.
      Mol. Plant Microbe Interact. 20:589-596(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    24. "Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis."
      Wang H., Ngwenyama N., Liu Y., Walker J.C., Zhang S.
      Plant Cell 19:63-73(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    25. "The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis."
      Takahashi F., Yoshida R., Ichimura K., Mizoguchi T., Seo S., Yonezawa M., Maruyama K., Yamaguchi-Shinozaki K., Shinozaki K.
      Plant Cell 19:805-818(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, FUNCTION.
    26. "The PP2C-type phosphatase AP2C1, which negatively regulates MPK4 and MPK6, modulates innate immunity, jasmonic acid, and ethylene levels in Arabidopsis."
      Schweighofer A., Kazanaviciute V., Scheikl E., Teige M., Doczi R., Hirt H., Schwanninger M., Kant M., Schuurink R., Mauch F., Buchala A., Cardinale F., Meskiene I.
      Plant Cell 19:2213-2224(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, INTERACTION WITH AP2C1.
    27. "The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling."
      Doczi R., Brader G., Pettko-Szandtner A., Rajh I., Djamei A., Pitzschke A., Teige M., Hirt H.
      Plant Cell 19:3266-3279(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    28. "Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling."
      Yoo S.D., Cho Y.H., Tena G., Xiong Y., Sheen J.
      Nature 451:789-795(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION.
    29. "AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis."
      Xing Y., Jia W., Zhang J.
      Plant J. 54:440-451(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    30. "Comprehensive analysis of protein-protein interactions between Arabidopsis MAPKs and MAPK kinases helps define potential MAPK signalling modules."
      Lee J.S., Huh K.W., Bhargava A., Ellis B.E.
      Plant Signal. Behav. 3:1037-1041(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MKK2; MKK4; MKK5 AND MKK6.
    31. "A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis."
      Ren D., Liu Y., Yang K.Y., Han L., Mao G., Glazebrook J., Zhang S.
      Proc. Natl. Acad. Sci. U.S.A. 105:5638-5643(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    32. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
      Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
      J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-226, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: cv. Columbia.
    33. "MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis."
      Bartels S., Anderson J.C., Gonzalez Besteiro M.A., Carreri A., Hirt H., Buchala A., Metraux J.P., Peck S.C., Ulm R.
      Plant Cell 21:2884-2897(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, DEPHOSPHORYLATION, INTERACTION WITH MKP1 AND PTP1.
    34. "AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination."
      Xing Y., Jia W., Zhang J.
      Plant Mol. Biol. 70:725-736(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    35. "An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence."
      Zhou C., Cai Z., Guo Y., Gan S.
      Plant Physiol. 150:167-177(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, DISRUPTION PHENOTYPE.
    36. "MAPK phosphatase MKP2 mediates disease responses in Arabidopsis and functionally interacts with MPK3 and MPK6."
      Lumbreras V., Vilela B., Irar S., Sole M., Capellades M., Valls M., Coca M., Pages M.
      Plant J. 63:1017-1030(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DSPTP1B/MKP2.
    37. "Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2."
      Vilela B., Pages M., Lumbreras V.
      Plant Signal. Behav. 5:1497-1500(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DSPTP1B/MKP2.
    38. "AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis."
      Zeng Q., Chen J.G., Ellis B.E.
      Plant J. 67:895-906(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MKK6.
    39. "Expression analysis of MAP2K9 and MAPK6 during pathogenesis of Alternaria blight in Arabidopsis thaliana ecotype Columbia."
      Kannan P., Pandey D., Gupta A.K., Punetha H., Taj G., Kumar A.
      Mol. Biol. Rep. 39:4439-4444(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY PATHOGEN.
    40. "A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation."
      Meng X., Wang H., He Y., Liu Y., Walker J.C., Torii K.U., Zhang S.
      Plant Cell 24:4948-4960(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiMPK6_ARATH
    AccessioniPrimary (citable) accession number: Q39026
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3