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Q39017

- DGK1_ARATH

UniProt

Q39017 - DGK1_ARATH

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Protein
Diacylglycerol kinase 1
Gene
DGK1, At5g07920, F13G24.120, MXM12.16
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress By similarity.

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri79 – 13759Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri149 – 21264Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. calcium ion binding Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. intracellular signal transduction Source: InterPro
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Plant defense, Stress response

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G07920-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase 1 (EC:2.7.1.107)
Short name:
AtDGK1
Short name:
DAG kinase 1
Alternative name(s):
Diglyceride kinase 1
Short name:
DGK 1
Gene namesi
Name:DGK1
Ordered Locus Names:At5g07920
ORF Names:F13G24.120, MXM12.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G07920.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4822Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Diacylglycerol kinase 1
PRO_0000218475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki491 – 491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki500 – 500Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ39017.
PRIDEiQ39017.

Expressioni

Tissue specificityi

Expressed in roots, shoots, and leaves.1 Publication

Inductioni

By volatile C6-aldehydes ((E)-2-hexenal, (Z)-3-hexenal, (Z)-3-hexenol), and allo-ocimene.1 Publication

Gene expression databases

GenevestigatoriQ39017.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi3702.AT5G07920.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ39017.
SMRiQ39017. Positions 78-137, 145-217.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini357 – 496140DAGKc
Add
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
HOGENOMiHOG000005923.
InParanoidiQ39017.
KOiK00901.
OMAiTISHHGQ.
PhylomeDBiQ39017.

Family and domain databases

InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39017-1 [UniParc]FASTAAdd to Basket

« Hide

MDDDGELGMF FPSWTSKNPI DTVESRGLMF SCFVAALVGI LTIAYTAFQW    50
RRNINLSWTK AIARSKKNPK ARHKVPVAPH SWELDPIARA KNLNCCVCLK 100
SMSPSQAIVA SESFFHRCTI CGAAAHFNCS SSAPKDCKCV SMVGFEHVVH 150
QWAVRWTEGA DQTDDSSFCS YCDESCSSSF LGGSPIWCCL WCQRLVHVDC 200
HSNMSNETGD ICDLGPLRRL ILCPLYVKEL TRNPSGGFLS SITHGANELA 250
STALASIRIQ SKKYKQTNET SADTGNSGSN CDESTESTAD TGPTVNGAHA 300
VLENSISVMN GDSSNGDSDS NGKLEKKPSV KRTGSFGQKE YHALRSKLKY 350
ELADLPSDAR PLLVFINKKS GAQRGDSLRQ RLHLHLNPVQ VFELSSVQGP 400
EVGLFLFRKV PHFRVLVCGG DGTAGWVLDA IEKQNFISPP AVAILPAGTG 450
NDLSRVLNWG GGLGSVERQG GLSTVLQNIE HAAVTVLDRW KVSILNQQGK 500
QLQPPKYMNN YIGVGCDAKV ALEIHNLREE NPERFYSQFM NKVLYAREGA 550
RSIMDRTFED FPWQVRVEVD GVDIEVPEDA EGILVANIGS YMGGVDLWQN 600
EDETYENFDP QSMHDKIVEV VSISGTWHLG KLQVGLSRAR RLAQGSAVKI 650
QLCAPLPVQI DGEPWNQQPC TLTISHHGQA FMLKRAAEEP LGHAAAIITD 700
VLENAETNQV INASQKRTLL QEMALRLT 728
Length:728
Mass (Da):79,984
Last modified:March 27, 2002 - v2
Checksum:i9E3190721C083DE9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti509 – 5091N → T in BAA09856. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63787 mRNA. Translation: BAA09856.1.
AL133421 Genomic DNA. Translation: CAB62604.1.
AB005249 Genomic DNA. Translation: BAB09956.1.
CP002688 Genomic DNA. Translation: AED91221.1.
BT004148 mRNA. Translation: AAO42169.1.
PIRiS71467.
RefSeqiNP_196409.1. NM_120874.2.
UniGeneiAt.260.

Genome annotation databases

EnsemblPlantsiAT5G07920.1; AT5G07920.1; AT5G07920.
GeneIDi830686.
KEGGiath:AT5G07920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63787 mRNA. Translation: BAA09856.1 .
AL133421 Genomic DNA. Translation: CAB62604.1 .
AB005249 Genomic DNA. Translation: BAB09956.1 .
CP002688 Genomic DNA. Translation: AED91221.1 .
BT004148 mRNA. Translation: AAO42169.1 .
PIRi S71467.
RefSeqi NP_196409.1. NM_120874.2.
UniGenei At.260.

3D structure databases

ProteinModelPortali Q39017.
SMRi Q39017. Positions 78-137, 145-217.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT5G07920.1-P.

Proteomic databases

PaxDbi Q39017.
PRIDEi Q39017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G07920.1 ; AT5G07920.1 ; AT5G07920 .
GeneIDi 830686.
KEGGi ath:AT5G07920.

Organism-specific databases

TAIRi AT5G07920.

Phylogenomic databases

eggNOGi NOG47311.
HOGENOMi HOG000005923.
InParanoidi Q39017.
KOi K00901.
OMAi TISHHGQ.
PhylomeDBi Q39017.

Enzyme and pathway databases

BioCyci ARA:AT5G07920-MONOMER.

Gene expression databases

Genevestigatori Q39017.

Family and domain databases

InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA encoding diacylglycerol kinase (DGK) in Arabidopsis thaliana."
    Katagiri T., Mizoguchi T., Shinozaki K.
    Plant Mol. Biol. 30:647-653(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
    Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
    DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Volatile C6-aldehydes and allo-ocimene activate defense genes and induce resistance against Botrytis cinerea in Arabidopsis thaliana."
    Kishimoto K., Matsui K., Ozawa R., Takabayashi J.
    Plant Cell Physiol. 46:1093-1102(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Multidimensional protein identification technology (MudPIT) analysis of ubiquitinated proteins in plants."
    Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.
    Mol. Cell. Proteomics 6:601-610(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-491 AND LYS-500.
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiDGK1_ARATH
AccessioniPrimary (citable) accession number: Q39017
Secondary accession number(s): Q9SD92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 27, 2002
Last modified: May 14, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Treatment with (E)-2-hexenal, (Z)-3-hexenal and allo-ocimene increases plant resistance against the necrotrophic fungal pathogen Botrytis cinerea (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi